The carbohydrate-deficient transferrin as a marker of chronic alcohol consumption and assessment of its usefulness in patients with cardiovascular diseases – a pilot study
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Figure 1.
An representative chromatogram shows the characteristic higher peaks occurring in the case of alcohol consumption - isoform asialotransferrin and disialotransferrin - positive result CDT) - A & sample chromatogram where no asialotransferrin is present and disialotransferrin is much lower – negative CDT - B (Chromsystems, Germany)
Figure 2.
Analysis of correlation between CDT and NT pro-BNP, troponin T, ALP and GGT
Figure 3.
ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 2.5
Figure 4.
ROC curve analysis of CDT, NT pro-BNP, Troponin T, ALP and GGT parameters to detect patients, for which CDT is over 1.2
Descriptive statistics for analyzed parameters
CDT
NT pro-BNP
Troponin T
ALP
GGT
N
59
59
59
59
59
Mean (SD)
1.5 (0.9)
5 123.1 ( 5911.5)
159.4 (576.1)
115.6 (89.5)
172.3 (175.0)
Median
1.3
2,983.0
28.1
92.0
102.0
Range
0.4 – 5.1
180.3 – 33 576.0
4.2 – 3,694.0
25.0 – 636.0
16.0 – 782.0
Area under the ROC curves for different parameters and CDT cut-offs