Prognostic value of SMAD4 in resectable pancreatic cancer
et
| 09 août 2022
Article Category: Original Study
Publié en ligne: 09 août 2022
Pages: 324 - 332
Reçu: 12 juin 2021
Accepté: 13 oct. 2021
© 2022 Hui Su et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Fig. 1
Systematic flow diagram for selection of included studiesFig. 2
Forest plot showing the association between the loss of SMAD4 expression and OS in PC using multivariate analysesFig. 3
Forest plot showing the association between the loss of SMAD4 expression and recurrence in PC. A. Local recurrence. B. Distant recurrenceFig. 4
Begg's funnel plot and Egger's funnel plot for all studies included in this meta-analysisFig. 5
Effect of individual studies on the pooled HR for OSOverview of the reviewed studies
Author, Year |
Country |
Group |
Histology |
Follow-up (Median/Months) |
Method |
Antibody (Dilution) |
Cutoff (%) |
Study Quality Score |
Oshima M 2013 [15] |
Japan |
SMAD4+SMAD4− |
PDAC |
62/44 |
IHC |
Santa 1:100 |
>0 |
8 |
Yamada S 2015 [16] |
Japan |
SMAD4+SMAD4− |
PDAC |
44/2659/45 |
IHC |
Santa 1:100 |
>0 |
7 |
Herman JM 2018 [17] |
USA |
SMAD4+SMAD4− |
PDAC |
36/2145/43 |
IHC |
---- |
>0 |
7 |
Tascilar M 2001 [18] |
USA |
SMAD4+SMAD4− |
PAC |
61/5078/60 |
IHC |
Santa 1:100 |
>0 |
9 |
Biankin AV 2002 [19] |
Australia |
SMAD4+SMAD4− |
PDAC |
190/158 |
IHC |
Santa |
>5 |
7 |
Xu JZ 2019 [20] |
China |
SMAD4+SMAD4− |
PDAC |
30/39102/66 |
IHC |
---- |
---- |
7 |
Ottenhof NA 2012 [21] |
The Netherlands |
SMAD4+SMAD4− |
PDAC |
35/43 |
IHC |
Santa 1:300 |
>0 |
8 |
Shen J 2019 [22] |
China |
SMAD4+SMAD4− |
PDAC |
---- |
IHC |
---- |
---- |
6 |
Toga T 2004 [23] |
Japan |
SMAD4+SMAD4− |
IDC |
6/737/38 |
IHC |
Santa 1:100 |
>10 |
6 |
Bachet JB 2012 [24] |
France |
SMAD4+ |
PDAC |
54 |
IHC |
Santa 1:50 |
>0 |
9 |
Winter JM 2013 [25] |
USA |
SMAD4− |
PDAC |
48 |
IHC |
Santa 1:800 |
>0 |
8 |
Shin SH 2017 [26] |
Korea |
SMAD4+ |
PDAC |
---- |
IHC |
Santa 1:100 |
>0 |
7 |