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Bovine Lung Peptides after Trypsinolysis Reveal Anti-Exudative Activity

U. J. Ishimov

U. J. Ishimov

  • Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
  • Tashkent Chemical-Technological InstituteTashkent, Uzbekistan
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Ishimov, U. J.
, 
N. Gafurova

N. Gafurova

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Gafurova, N.
, 
A. M. Asrorov

A. M. Asrorov

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Asrorov, A. M.
, 
A. Wali

A. Wali

Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of ScienceÜrümqi, China
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Wali, A.
, 
N. Mukhamedov

N. Mukhamedov

  • Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
  • National University of UzbekistanTashkent, Uzbekistan
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Mukhamedov, N.
, 
S. O. Olimjonov

S. O. Olimjonov

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Olimjonov, S. O.
, 
N. Vypova

N. Vypova

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Vypova, N.
, 
S. Khamidov

S. Khamidov

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Khamidov, S.
, 
S. Sh. Abdirahimova

S. Sh. Abdirahimova

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Abdirahimova, S. Sh.
 et 
J. F. Ziyavitdinov

J. F. Ziyavitdinov

Institute of Bioorganic Chemistry, Uzbekistan Academy of SciencesTashkent, Uzbekistan
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Ziyavitdinov, J. F.
  
04 déc. 2024
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Catégorie d'article: Research paper
Publié en ligne: 04 déc. 2024
Pages: 16 - 24
Reçu: 08 avr. 2024
Accepté: 08 oct. 2024
DOI: https://doi.org/10.2478/afpuc-2024-0011
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© 2024 U. J. Ishimov et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Preventive effect of the peptides sum on the dynamics of inflammation in rats bearing carrageenan edema model (increase in the volume of the limbs, % relative to the initial one, n = 6).
Preventive effect of the peptides sum on the dynamics of inflammation in rats bearing carrageenan edema model (increase in the volume of the limbs, % relative to the initial one, n = 6).

Figure 2.

Effect of the peptides sum, ASA, and prednisolone on the dynamics of inflammation in rats on the model of exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6). (a) Increase in paw volume 3 h after induction, %. (b) Anti-exudative activity, %. *P £ 0.05, **P £ 0.01, ***P £ 0.005. ASA, acetylsalicylic acid.
Effect of the peptides sum, ASA, and prednisolone on the dynamics of inflammation in rats on the model of exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6). (a) Increase in paw volume 3 h after induction, %. (b) Anti-exudative activity, %. *P £ 0.05, **P £ 0.01, ***P £ 0.005. ASA, acetylsalicylic acid.

Figure 3.

The therapeutic effect of the peptides sum on the dynamics of inflammation in rats bearing exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6).
The therapeutic effect of the peptides sum on the dynamics of inflammation in rats bearing exudative inflammation induced by carrageenan (increase in the volume of the limbs, % relative to the initial one, n = 6).

Figure 4.

The effect of the sum peptides on the dynamics of inflammation in rats using a model of exudative inflammation induced by formalin (increase in the volume of the limbs, % relative to the initial one, n = 6).
The effect of the sum peptides on the dynamics of inflammation in rats using a model of exudative inflammation induced by formalin (increase in the volume of the limbs, % relative to the initial one, n = 6).

Effects of peptides sum and prednisolone on biochemical blood parameters in experimental cotton wool granuloma_

Biochemical parameters Control Prednisolone (10 mg/kg) Peptides sum (10−6 mg/kg) Peptides sum (10−4 mg/kg)
Glucose (mmol/L) 6.15 ± 0.13 5.97 ± 0.15 4.93 ± 0.59 4.83 ± 0.13
ALT (U/L) 72.3 ± 3.93 56.7 ± 4.18* 47.0 ± 6.57** 61.3 ± 2.97*
AST (U/L) 140.7 ± 3.18 154.7 ± 11.1 147.7 ± 11.7 150.3 ± 16.2
Total protein (g/L) 70.2 ± 1.59 64.8 ± 1.91 76.0 ± 1.16 72.3 ± 0.33
Bilirubin (μmol/L) 4.2 ± 0.66 4.17 ± 0.81 4.47 ± 0.97 4.2 ± 7.0
Creatinine (μmol/L) 42.9 ± 1.91 38.7 ± 1.35 45.0 ± 2.0 48.0 ± 3.8
Urea (mmol/L) 6.8 ± 0.89 6.33 ± 0.93 6.23 ± 0.45 7.87 ± 1.43
CRP (mg/L) 30.0 ± 0.4 29.0 ± 1.5 28.0 ± 0.7 26.0 ± 0.9
ASO (mmol/mL) 23.77 ± 7.2 10.9 ± 1.64* 10.0 ± 0.06* 9.47 ± 0.47*

Molecular masses of peptides isolated from the substance peptides sum_

Sequence MM Accession Protein name
RVGAGAPVYLAAVLEYLTAEILELAGNAARD 2915.588 28195394 Histone cluster 2, H2ab
KFFSAVSTVLTSKY 1286.7 122405 Hemoglobin alpha chain
RAGLQFPVGRI 944.532 4504255 H2A histone family, member Z
RLLVVYPWTQRF 1274.726 4504351 Delta globin
KVNVDEVGGEALGRL 1314.665 4504349 Beta globin
KSAVTALWGKV 932.52 4504349 Beta globin
KSLVSGLWGKV 946.536 57113367 Similar to beta globin
KVFLENVIRD 989.578 817960 Histone H4 (55AA)
RLLLPGELAKH 953.604 1568557 Histone H2B
RISGLIYEETRG 1180.621 4504301 Histone cluster 1, H4a
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