PM1 | β-cyclodextrin | 1:3 |
PM2 | β-cyclodextrin | 1:4 |
PM3 | β-cyclodextrin | 1:5 |
PM4 | PVP K30 | 1:3 |
PM5 | PVP K30 | 1:4 |
PM6 | PVP K30 | 1:5 |
PM7 | Poloxamer 188 | 1:3 |
PM8 | Poloxamer 188 | 1:4 |
PM9 | Poloxamer 188 | 1:5 |
1 | 2 | 0.223±0.29 |
2 | 4 | 0.402±0.24 |
3 | 6 | 0.543±0.20 |
4 | 8 | 0.707±0.16 |
5 | 10 | 0.862±0.11 |
6 | 12 | 1.029±0.09 |
5 | 6.12±0.2 | 7.42±1.3 | 10.2±2.4 | 14.8±0.2 | 12.9±1.1 | 12.7±2.1 | 11.7±1.0 | 26.4±0.3 | 34.4±0.2 |
10 | 10.3±0.5 | 11.8±1.4 | 14.7±2.1 | 20.0±0.4 | 25.8±1.3 | 19.4±1.2 | 37.3±1.2 | 51.9±0.5 | 60.1±2.0 |
15 | 12.1±0.7 | 16.5±1.6 | 22.1±2.6 | 25.6±0.2 | 36±1.4 | 60.3±1.1 | 57.3±1.3 | 70.5±0.6 | 74.5±2.2 |
30 | 22.4±0.9 | 31.7±1.9 | 27.0±2.7 | 43.5±0.1 | 72.2±1.1 | 72.9±0.2 | 68.3±1.5 | 94.2±0.8 | 96.8±2.0 |
45 | 27.7±1.2 | 41.8±2.6 | 46.3±2.8 | 49.4±0.2 | 98.7±1.1 | 79.8±0.2 | 85.9±1.0 | 96.9±0.9 | 99.6±1.0 |
60 | 39.8±1.5 | 44.8±2.1 | 58.3±2.1 | 75.7±0.9 | 100.2±1.6 | 99. 6±0.1 | 91.4±0.1 | 99.9±1.0 | 99.6±1.1 |
IF1 | 215.3±2.5 | 4.75±0.3 | 2.03±0.5 | 0.228±0.3 | 92.66±3.5 | 5.3±0.2 |
IF2 | 212.3±2.5 | 4.56±0.3 | 2.12±0.1 | 0.456±0.9 | 97.15±1.4 | 6.2±0.4 |
IF3 | 218.3±1.5 | 4.75±0.3 | 2.09±0.4 | 0.227±2.1 | 100.3±0.8 | 4.5±2.1 |
VAL | 42.54±0.2 | 542±0.2 | 522±1.1 | 27.38±1.1 | 1.37±2.0 |
IF1 | 28.36±0.3 | 600±0.6 | 666.6±1.2 | 9.99±1.2 | 1.11±1.3 |
IF2 | 22.92±0.6 | 500±0.5 | 600±1.5 | 6.66±2.0 | 1.12±0.6 |
IF3 | 28.88±0.5 | 461.5±30.9 | 491.8±2.0 | 6.15±2.5 | 1.06±3.2 |
Initial | 0 | 97.15±1.4 | 6.2±0.4 | 99.69±0.01 |
Accelerated (40±2°C at 75±5% RH) | 6 | 96.99±1.1 | 6.1±0.2 | 99.64±0.02 |
Long term (25±2°C at 60±5% RH) | 12 | 97.11±0.9 | 6.1±0.5 | 99.59±0.03 |
IF1 | 200 | 6.9 | 20.8 | 2.3 | 230 |
IF2 | 200 | 9.2 | 18.5 | 2.3 | 230 |
IF3 | 200 | 11.5 | 16.2 | 2.3 | 230 |