Evaluation of variability of silymarin complex in Silybi mariani fructus harvested during two production years

[1] Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy Research 2010;24:1423–1432. AbenavoliL CapassoR MilicN CapassoF Milk thistle in liver diseases: past, present, future Phytotherapy Research 2010 24 1423 1432 10.1002/ptr.320720564545 Search in Google Scholar

[2] Abouzid SF, Chen SN, Mcalpine JB, Friesen JB, Pauli GF. Silybum marianum pericarp yields enhanced silymarin products. J. Fitote. 2016;56:136–143. AbouzidSF ChenSN McalpineJB FriesenJB PauliGF Silybum marianum pericarp yields enhanced silymarin products J. Fitote. 2016 56 136 143 10.1016/j.fitote.2016.05.012493913927233988 Search in Google Scholar

[3] Alhadidi Q, Ahmed ZA, Numan IT, Hussain SAR. Dose-dependent anti-inflammatory effect of silymarin in experimental animal model of chronic inflammation. Afr. J. Pharm. Pharmacol. 2009;3:242–247. AlhadidiQ AhmedZA NumanIT HussainSAR Dose-dependent anti-inflammatory effect of silymarin in experimental animal model of chronic inflammation Afr. J. Pharm. Pharmacol. 2009 3 242 247 Search in Google Scholar

[4] Andrzejewska J, Sadowska K, Mielcarek S. Effect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn.) grown on light soil in a moderate climate. J. Ind. Crop. 2011;33:462–468. AndrzejewskaJ SadowskaK MielcarekS Effect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn.) grown on light soil in a moderate climate J. Ind. Crop. 2011 33 462 468 10.1016/j.indcrop.2010.10.027 Search in Google Scholar

[5] Arampatzis AD, Karkanis CA, Tsiropoulos GN. Siymarin content and antioxidant activity of seeds of wild Silybum marianum populations growing in Greece. J AAB. 2018;174. ArampatzisAD KarkanisCA TsiropoulosGN Siymarin content and antioxidant activity of seeds of wild Silybum marianum populations growing in Greece J AAB. 2018 174 10.1111/aab.12470 Search in Google Scholar

[6] Ashie A, Lei H, Han B, Xiong M, Yan H. Fast determination of free components in milk thistle extract with a hand-held NIR spectrometer and chemometrics tools. Infra Phys Tech. 2021;113:103629. AshieA LeiH HanB XiongM YanH Fast determination of free components in milk thistle extract with a hand-held NIR spectrometer and chemometrics tools Infra Phys Tech. 2021 113 103629 10.1016/j.infrared.2021.103629 Search in Google Scholar

[7] Block KI, Gyllenhaal C, Lowe L, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015;35:276–304. BlockKI GyllenhaalC LoweL Designing a broad-spectrum integrative approach for cancer prevention and treatment Semin Cancer Biol. 2015 35 276 304 10.1016/j.semcancer.2015.09.007481900226590477 Search in Google Scholar

[8] Borah A, Paul R, Choudhury S, et al. Neuroprotective potential of silymarin against CNS disorders: Insight into the pathways and molecular mechanisms of action. CNS. 2013;19:847–853. BorahA PaulR ChoudhuryS Neuroprotective potential of silymarin against CNS disorders: Insight into the pathways and molecular mechanisms of action CNS 2013 19 847 853 10.1111/cns.12175649356524118806 Search in Google Scholar

[9] Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev. 2010;29:447–463. DeepG AgarwalR Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer Cancer Metastasis Rev. 2010 29 447 463 10.1007/s10555-010-9237-0392836120714788 Search in Google Scholar

[10] Drouet S, Leclerc AE, Garros L. A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications. Antioxidants. 2019;8:304. DrouetS LeclercAE GarrosL A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn Fruits for Cosmetic Applications. Antioxidants. 2019 8 304 10.3390/antiox8080304672120231416140 Search in Google Scholar

[11] Elateeq AA, Sun Y, Nxumalo W, Gabr MMA. Biotechnological production of silymarin in Silybum marianum L.: A review. J. BCAB. 2020;29:101775. ElateeqAA SunY NxumaloW GabrMMA Biotechnological production of silymarin in Silybum marianum L.: A review J. BCAB. 2020 29 101775 10.1016/j.bcab.2020.101775 Search in Google Scholar

[12] European Pharmacopoeia: 10th Edition. Strasbourg: EDQM Publications; 2020. European Pharmacopoeia 10th Edition Strasbourg EDQM Publications 2020 Search in Google Scholar

[13] Ghafor Y, Mohammad NN, Salh DM. Extraction and Determination of Chemical Ingredients from Stems of Silybum Marianum. CMR. 2014;6:26–32. GhaforY MohammadNN SalhDM Extraction and Determination of Chemical Ingredients from Stems of Silybum Marianum CMR 2014 6 26 32 Search in Google Scholar

[14] Ghorbani A. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (Part 1): General results. J Ethpharm. 2005;102:58–68. GhorbaniA Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (Part 1): General results J Ethpharm 2005 102 58 68 10.1016/j.jep.2005.05.03516024194 Search in Google Scholar

[15] Giuliani C, Tani C, Bini LM, Fico G, Colombo R, Martinelli T. Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. J. Fitote. 2018:210–218. GiulianiC TaniC BiniLM FicoG ColomboR MartinelliT Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour J. Fitote. 2018 210 218 10.1016/j.fitote.2018.09.00230213759 Search in Google Scholar

[16] Jedlinszki N, Kálomista I, Galbács G, Csupor D. Silybum marianum (milk thistle) products in Wilson's disease: a treatment or a threat? J. Her. Med. 2016;6:157–159. JedlinszkiN KálomistaI GalbácsG CsuporD Silybum marianum (milk thistle) products in Wilson's disease: a treatment or a threat? J. Her. Med 2016 6 157 159 10.1016/j.hermed.2016.06.002 Search in Google Scholar

[17] Karkanis A, Bilalis D, Efthimiadou A. Cultivation of milk thistle (Silybum marianum L. Gaertn.), a medicinal weed. J Ind Crop. 2011;1:825–830. KarkanisA BilalisD EfthimiadouA Cultivation of milk thistle (Silybum marianum L. Gaertn.), a medicinal weed J Ind Crop. 2011 1 825 830 10.1016/j.indcrop.2011.03.027 Search in Google Scholar

[18] Khan AM, Abbasi HB, Shah AN, Yücesan B, Ali H. Analysis of metabolic variations throughout growth and development of adventitious roots in Silybum marianum L. (Milk thistle), a medicinal plant. PCTOC. 2015;123:501–510. KhanAM AbbasiHB ShahAN YücesanB AliH Analysis of metabolic variations throughout growth and development of adventitious roots in Silybum marianum L. (Milk thistle), a medicinal plant PCTOC 2015 123 501 510 10.1007/s11240-015-0854-8 Search in Google Scholar

[19] Li D, Hu J, Wang T, et al. Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells. Sci rep. 2016;6. LiD HuJ WangT Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells Sci rep. 2016 6 10.1038/srep37751511878727874084 Search in Google Scholar

[20] Li L, Zeng J, Gao Y, He D. Targeting silibinin in the antiproliferative pathway. Expert Opinion on Investigational Drugs. 2010;19:243–255. LiL ZengJ GaoY HeD Targeting silibinin in the antiproliferative pathway Expert Opinion on Investigational Drugs 2010 19 243 255 10.1517/1354378090353363120047507 Search in Google Scholar

[21] Lucini L, Pellizzonii M, Pellegrino R, Molinari GP, Colla G. Phytochemical constituents and in vitro radical scavenging activity of different Aloe species. J Food Chem. 2015;170:501–507. LuciniL PellizzoniiM PellegrinoR MolinariGP CollaG Phytochemical constituents and in vitro radical scavenging activity of different Aloe species J Food Chem 2015 170 501 507 10.1016/j.foodchem.2014.08.03425306376 Search in Google Scholar

[22] Marmouzi I, Bouyahaya A, Ezzat MS, Jemli EM, Kharbach M. The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence. J Ethpharm. 2021;265:113303. MarmouziI BouyahayaA EzzatMS JemliEM KharbachM The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence J Ethpharm. 2021 265 113303 10.1016/j.jep.2020.11330332877720 Search in Google Scholar

[23] Mei L, Wang L, Li Q, Yu J, Xu X. Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil. J. Sci. Food Agric. 2013;93:2822–2828. MeiL WangL LiQ YuJ XuX Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil J. Sci. Food Agric. 2013 93 2822 2828 10.1002/jsfa.610923426870 Search in Google Scholar

[24] Mirdeilami ZS, Barani H, Mazandarani M, Heshmati AG. Ethnopharmacological Survey of Medicinal Plantsin Maraveh Tappeh Region, NorthofIran. J.P.P. 2011;2:325–336. MirdeilamiZS BaraniH MazandaraniM HeshmatiAG Ethnopharmacological Survey of Medicinal Plantsin Maraveh Tappeh Region, NorthofIran J.P.P. 2011 2 325 336 Search in Google Scholar

[25] Nagy M, Muèaji P, Granèai D. Farmakognózia. Biologicky aktívne rastlinné metabolity a ich zdroje. Bratislava: Herba; 2015. NagyM MuèajiP GranèaiD Farmakognózia. Biologicky aktívne rastlinné metabolity a ich zdroje Bratislava Herba 2015 Search in Google Scholar

[26] Pendry BA, Kemp V, Hughes MJ, et al. Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures. J Herb Med. 2017;10:31–36. PendryBA KempV HughesMJ Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures J Herb Med 2017 10 31 36 10.1016/j.hermed.2017.07.001 Search in Google Scholar

[27] Polyak JS, Ferenci P, Pawlotsky MJ. Hepatoprotective and Antiviral Functions of Silymarin Components in HCV Infection. PMC. 2014;57:1262–1271. PolyakJS FerenciP PawlotskyMJ Hepatoprotective and Antiviral Functions of Silymarin Components in HCV Infection PMC 2014 57 1262 1271 Search in Google Scholar

[28] Poppe L, Peretsen M. Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived thereform. J Phyto. 2016;131:68–75. PoppeL PeretsenM Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived thereform J Phyto 2016 131 68 75 Search in Google Scholar

[29] Qin N, Jia C, Xu J, Li D et al. New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities. J. Fitot. 2017;119:83–89. QinN JiaC XuJ LiD New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities J. Fitot 2017 119 83 89 10.1016/j.fitote.2017.04.00828400224 Search in Google Scholar

[30] Ražná K, Hlavačková L, Bežo M et al. Application of the RAPD and miRNA markers in the genotyping of Silybum marianum (L.) Gaertn. Acta fytotechn zootechn. 2015;18:83–89. RažnáK HlavačkováL BežoM Application of the RAPD and miRNA markers in the genotyping of Silybum marianum (L.) Gaertn Acta fytotechn zootechn 2015 18 83 89 10.15414/afz.2015.18.04.83-89 Search in Google Scholar

[31] Rodriguez-Saona EL, Fry SF, Calvey ME. Use of Fourier Transform Near-Infrared Reflectance Spectroscopy for Rapid Quantification of Castor Bean Meal in a Selection of Flour-Based Products. J. Agric. Food. Chem. 2000;48:5169–5177. Rodriguez-SaonaEL FrySF CalveyME Use of Fourier Transform Near-Infrared Reflectance Spectroscopy for Rapid Quantification of Castor Bean Meal in a Selection of Flour-Based Products J. Agric. Food. Chem. 2000 48 5169 5177 10.1021/jf000604m11087454 Search in Google Scholar

[32] Singh RP, Tyagi AK Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcin. 2002;23:499–510. SinghRP TyagiAK ZhaoJ AgarwalR Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis Carcin 2002 23 499 510 10.1093/carcin/23.3.49911895866 Search in Google Scholar

[33] Tyagi A, Bhatia N, Condon MS, Bosland MC, Agarwal C, Agarwal R. Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells. Pros. 2002;53:211–217. TyagiA BhatiaN CondonMS BoslandMC AgarwalC AgarwalR Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells Pros 2002 53 211 217 10.1002/pros.1014612386921 Search in Google Scholar

[34] Vagnerova L, Bradacova M, Pluhackova H. The Determination of Contained Compounds in Milk Thistle (Silybum marianum L. (Gaertn.)). Mendel Net. 2016;23:168–172. VagnerovaL BradacovaM PluhackovaH The Determination of Contained Compounds in Milk Thistle (Silybum marianum L. (Gaertn.)) Mendel Net 2016 23 168 172 Search in Google Scholar

[35] Wallace SN, Carrier DJ, Clausen EC. Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner). Phytochem. Anal. 2005;16:7–16. WallaceSN CarrierDJ ClausenEC Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner) Phytochem. Anal. 2005 16 7 16 10.1002/pca.80315688950 Search in Google Scholar

[36] Wianowska D, Wiśniewski M. Simplified Procedure of Silymarin Extraction from Silybum marianum L. Gaertner. J. Chrom. Sci. 2015;53:366–372. WianowskaD WiśniewskiM Simplified Procedure of Silymarin Extraction from Silybum marianum L. Gaertner J. Chrom. Sci. 2015 53 366 372 10.1093/chromsci/bmu04924895445 Search in Google Scholar