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Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytotherapy Research 2010;24:1423–1432.AbenavoliLCapassoRMilicNCapassoFMilk thistle in liver diseases: past, present, futurePhytotherapy Research2010241423143210.1002/ptr.320720564545Search in Google Scholar
Abouzid SF, Chen SN, Mcalpine JB, Friesen JB, Pauli GF. Silybum marianum pericarp yields enhanced silymarin products. J. Fitote. 2016;56:136–143.AbouzidSFChenSNMcalpineJBFriesenJBPauliGFSilybum marianum pericarp yields enhanced silymarin productsJ. Fitote.20165613614310.1016/j.fitote.2016.05.012493913927233988Search in Google Scholar
Alhadidi Q, Ahmed ZA, Numan IT, Hussain SAR. Dose-dependent anti-inflammatory effect of silymarin in experimental animal model of chronic inflammation. Afr. J. Pharm. Pharmacol. 2009;3:242–247.AlhadidiQAhmedZANumanITHussainSARDose-dependent anti-inflammatory effect of silymarin in experimental animal model of chronic inflammationAfr. J. Pharm. Pharmacol.20093242247Search in Google Scholar
Andrzejewska J, Sadowska K, Mielcarek S. Effect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn.) grown on light soil in a moderate climate. J. Ind. Crop. 2011;33:462–468.AndrzejewskaJSadowskaKMielcarekSEffect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn.) grown on light soil in a moderate climateJ. Ind. Crop.20113346246810.1016/j.indcrop.2010.10.027Search in Google Scholar
Arampatzis AD, Karkanis CA, Tsiropoulos GN. Siymarin content and antioxidant activity of seeds of wild Silybum marianum populations growing in Greece. J AAB. 2018;174.ArampatzisADKarkanisCATsiropoulosGNSiymarin content and antioxidant activity of seeds of wild Silybum marianum populations growing in GreeceJ AAB.201817410.1111/aab.12470Search in Google Scholar
Ashie A, Lei H, Han B, Xiong M, Yan H. Fast determination of free components in milk thistle extract with a hand-held NIR spectrometer and chemometrics tools. Infra Phys Tech. 2021;113:103629.AshieALeiHHanBXiongMYanHFast determination of free components in milk thistle extract with a hand-held NIR spectrometer and chemometrics toolsInfra Phys Tech.202111310362910.1016/j.infrared.2021.103629Search in Google Scholar
Block KI, Gyllenhaal C, Lowe L, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015;35:276–304.BlockKIGyllenhaalCLoweLDesigning a broad-spectrum integrative approach for cancer prevention and treatmentSemin Cancer Biol.20153527630410.1016/j.semcancer.2015.09.007481900226590477Search in Google Scholar
Borah A, Paul R, Choudhury S, et al. Neuroprotective potential of silymarin against CNS disorders: Insight into the pathways and molecular mechanisms of action. CNS. 2013;19:847–853.BorahAPaulRChoudhurySNeuroprotective potential of silymarin against CNS disorders: Insight into the pathways and molecular mechanisms of actionCNS20131984785310.1111/cns.12175649356524118806Search in Google Scholar
Deep G, Agarwal R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev. 2010;29:447–463.DeepGAgarwalRAntimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancerCancer Metastasis Rev.20102944746310.1007/s10555-010-9237-0392836120714788Search in Google Scholar
Drouet S, Leclerc AE, Garros L. A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) Gaertn. Fruits for Cosmetic Applications. Antioxidants. 2019;8:304.DrouetSLeclercAEGarrosLA Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle Silybum marianum (L.) GaertnFruits for Cosmetic Applications. Antioxidants.2019830410.3390/antiox8080304672120231416140Search in Google Scholar
Elateeq AA, Sun Y, Nxumalo W, Gabr MMA. Biotechnological production of silymarin in Silybum marianum L.: A review. J. BCAB. 2020;29:101775.ElateeqAASunYNxumaloWGabrMMABiotechnological production of silymarin in Silybum marianum L.: A reviewJ. BCAB.20202910177510.1016/j.bcab.2020.101775Search in Google Scholar
European Pharmacopoeia: 10th Edition. Strasbourg: EDQM Publications; 2020.European Pharmacopoeia10th EditionStrasbourgEDQM Publications2020Search in Google Scholar
Ghafor Y, Mohammad NN, Salh DM. Extraction and Determination of Chemical Ingredients from Stems of Silybum Marianum. CMR. 2014;6:26–32.GhaforYMohammadNNSalhDMExtraction and Determination of Chemical Ingredients from Stems of Silybum MarianumCMR201462632Search in Google Scholar
Ghorbani A. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (Part 1): General results. J Ethpharm. 2005;102:58–68.GhorbaniAStudies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran: (Part 1): General resultsJ Ethpharm2005102586810.1016/j.jep.2005.05.03516024194Search in Google Scholar
Giuliani C, Tani C, Bini LM, Fico G, Colombo R, Martinelli T. Localization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colour. J. Fitote. 2018:210–218.GiulianiCTaniCBiniLMFicoGColomboRMartinelliTLocalization of phenolic compounds in the fruits of Silybum marianum characterized by different silymarin chemotype and altered colourJ. Fitote.201821021810.1016/j.fitote.2018.09.00230213759Search in Google Scholar
Jedlinszki N, Kálomista I, Galbács G, Csupor D. Silybum marianum (milk thistle) products in Wilson's disease: a treatment or a threat? J. Her. Med. 2016;6:157–159.JedlinszkiNKálomistaIGalbácsGCsuporDSilybum marianum (milk thistle) products in Wilson's disease: a treatment or a threat?J. Her. Med2016615715910.1016/j.hermed.2016.06.002Search in Google Scholar
Karkanis A, Bilalis D, Efthimiadou A. Cultivation of milk thistle (Silybum marianum L. Gaertn.), a medicinal weed. J Ind Crop. 2011;1:825–830.KarkanisABilalisDEfthimiadouACultivation of milk thistle (Silybum marianum L. Gaertn.), a medicinal weedJ Ind Crop.2011182583010.1016/j.indcrop.2011.03.027Search in Google Scholar
Khan AM, Abbasi HB, Shah AN, Yücesan B, Ali H. Analysis of metabolic variations throughout growth and development of adventitious roots in Silybum marianum L. (Milk thistle), a medicinal plant. PCTOC. 2015;123:501–510.KhanAMAbbasiHBShahANYücesanBAliHAnalysis of metabolic variations throughout growth and development of adventitious roots in Silybum marianum L. (Milk thistle), a medicinal plantPCTOC201512350151010.1007/s11240-015-0854-8Search in Google Scholar
Li D, Hu J, Wang T, et al. Silymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cells. Sci rep. 2016;6.LiDHuJWangTSilymarin attenuates cigarette smoke extract-induced inflammation via simultaneous inhibition of autophagy and ERK/p38 MAPK pathway in human bronchial epithelial cellsSci rep.2016610.1038/srep37751511878727874084Search in Google Scholar
Li L, Zeng J, Gao Y, He D. Targeting silibinin in the antiproliferative pathway. Expert Opinion on Investigational Drugs. 2010;19:243–255.LiLZengJGaoYHeDTargeting silibinin in the antiproliferative pathwayExpert Opinion on Investigational Drugs20101924325510.1517/1354378090353363120047507Search in Google Scholar
Lucini L, Pellizzonii M, Pellegrino R, Molinari GP, Colla G. Phytochemical constituents and in vitro radical scavenging activity of different Aloe species. J Food Chem. 2015;170:501–507.LuciniLPellizzoniiMPellegrinoRMolinariGPCollaGPhytochemical constituents and in vitro radical scavenging activity of different Aloe speciesJ Food Chem201517050150710.1016/j.foodchem.2014.08.03425306376Search in Google Scholar
Marmouzi I, Bouyahaya A, Ezzat MS, Jemli EM, Kharbach M. The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence. J Ethpharm. 2021;265:113303.MarmouziIBouyahayaAEzzatMSJemliEMKharbachMThe food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidenceJ Ethpharm.202126511330310.1016/j.jep.2020.11330332877720Search in Google Scholar
Mei L, Wang L, Li Q, Yu J, Xu X. Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil. J. Sci. Food Agric. 2013;93:2822–2828.MeiLWangLLiQYuJXuXComparison of acid degumming and enzymatic degumming process for Silybum marianum seed oilJ. Sci. Food Agric.2013932822282810.1002/jsfa.610923426870Search in Google Scholar
Mirdeilami ZS, Barani H, Mazandarani M, Heshmati AG. Ethnopharmacological Survey of Medicinal Plantsin Maraveh Tappeh Region, NorthofIran. J.P.P. 2011;2:325–336.MirdeilamiZSBaraniHMazandaraniMHeshmatiAGEthnopharmacological Survey of Medicinal Plantsin Maraveh Tappeh Region, NorthofIranJ.P.P.20112325336Search in Google Scholar
Nagy M, Muèaji P, Granèai D. Farmakognózia. Biologicky aktívne rastlinné metabolity a ich zdroje. Bratislava: Herba; 2015.NagyMMuèajiPGranèaiDFarmakognózia. Biologicky aktívne rastlinné metabolity a ich zdrojeBratislavaHerba2015Search in Google Scholar
Pendry BA, Kemp V, Hughes MJ, et al. Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures. J Herb Med. 2017;10:31–36.PendryBAKempVHughesMJSilymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tincturesJ Herb Med201710313610.1016/j.hermed.2017.07.001Search in Google Scholar
Polyak JS, Ferenci P, Pawlotsky MJ. Hepatoprotective and Antiviral Functions of Silymarin Components in HCV Infection. PMC. 2014;57:1262–1271.PolyakJSFerenciPPawlotskyMJHepatoprotective and Antiviral Functions of Silymarin Components in HCV InfectionPMC20145712621271Search in Google Scholar
Poppe L, Peretsen M. Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived thereform. J Phyto. 2016;131:68–75.PoppeLPeretsenMVariation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived thereformJ Phyto20161316875Search in Google Scholar
Qin N, Jia C, Xu J, Li D et al. New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities. J. Fitot. 2017;119:83–89.QinNJiaCXuJLiDNew amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activitiesJ. Fitot2017119838910.1016/j.fitote.2017.04.00828400224Search in Google Scholar
Ražná K, Hlavačková L, Bežo M et al. Application of the RAPD and miRNA markers in the genotyping of Silybum marianum (L.) Gaertn. Acta fytotechn zootechn. 2015;18:83–89.RažnáKHlavačkováLBežoMApplication of the RAPD and miRNA markers in the genotyping of Silybum marianum (L.) GaertnActa fytotechn zootechn201518838910.15414/afz.2015.18.04.83-89Search in Google Scholar
Rodriguez-Saona EL, Fry SF, Calvey ME. Use of Fourier Transform Near-Infrared Reflectance Spectroscopy for Rapid Quantification of Castor Bean Meal in a Selection of Flour-Based Products. J. Agric. Food. Chem. 2000;48:5169–5177.Rodriguez-SaonaELFrySFCalveyMEUse of Fourier Transform Near-Infrared Reflectance Spectroscopy for Rapid Quantification of Castor Bean Meal in a Selection of Flour-Based ProductsJ. Agric. Food. Chem.2000485169517710.1021/jf000604m11087454Search in Google Scholar
Singh RP, Tyagi AK Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcin. 2002;23:499–510.SinghRPTyagiAKZhaoJAgarwalRSilymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosisCarcin20022349951010.1093/carcin/23.3.49911895866Search in Google Scholar
Tyagi A, Bhatia N, Condon MS, Bosland MC, Agarwal C, Agarwal R. Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells. Pros. 2002;53:211–217.TyagiABhatiaNCondonMSBoslandMCAgarwalCAgarwalRAntiproliferative and apoptotic effects of silibinin in rat prostate cancer cellsPros20025321121710.1002/pros.1014612386921Search in Google Scholar
Vagnerova L, Bradacova M, Pluhackova H. The Determination of Contained Compounds in Milk Thistle (Silybum marianum L. (Gaertn.)). Mendel Net. 2016;23:168–172.VagnerovaLBradacovaMPluhackovaHThe Determination of Contained Compounds in Milk Thistle (Silybum marianum L. (Gaertn.))Mendel Net201623168172Search in Google Scholar
Wallace SN, Carrier DJ, Clausen EC. Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner). Phytochem. Anal. 2005;16:7–16.WallaceSNCarrierDJClausenECBatch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. Gaertner)Phytochem. Anal.20051671610.1002/pca.80315688950Search in Google Scholar
Wianowska D, Wiśniewski M. Simplified Procedure of Silymarin Extraction from Silybum marianum L. Gaertner. J. Chrom. Sci. 2015;53:366–372.WianowskaDWiśniewskiMSimplified Procedure of Silymarin Extraction from Silybum marianum L. GaertnerJ. Chrom. Sci.20155336637210.1093/chromsci/bmu04924895445Search in Google Scholar