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Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Manojkumar S. Mahajan
Manojkumar S. Mahajan
, 
Aman B. Upaganlawar
Aman B. Upaganlawar
 et 
Chandrashekar D. Upasani
Chandrashekar D. Upasani
   | 18 juin 2021
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Article Category: Original Paper
Publié en ligne: 18 juin 2021
Pages: 30 - 39
Reçu: 03 nov. 2020
Accepté: 29 mars 2021
DOI: https://doi.org/10.2478/afpuc-2020-0020
Mots clés
© 2021 Mahajan Manojkumar S. et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Effect of CoQ10, NAC or their combination on a) serum urea, b) BUN and c) uric acid.
Effect of CoQ10, NAC or their combination on a) serum urea, b) BUN and c) uric acid.

Figure 2

Effect of CoQ10, NAC or their combination on a) urine volume (mL/Day), b) urinary protein (mg/dL) and c) UAER (μg/min).
Effect of CoQ10, NAC or their combination on a) urine volume (mL/Day), b) urinary protein (mg/dL) and c) UAER (μg/min).

Figure 3

Effect of CoQ10, NAC or their combination on renal OS and anti-oxidant markers a) MDA, b) SOD, c) CAT and d) GSH.
Effect of CoQ10, NAC or their combination on renal OS and anti-oxidant markers a) MDA, b) SOD, c) CAT and d) GSH.

Effect of CoQ10, NAC or their combination on MPO activity and NO in renal tissue.

Groups MPO NO
(U/g Tissue) (μmol/g Tissue)
Control 8.00 ± 0.718 4.38 ± 0.567
STZ-NAD DN 27.28 ± 0.871a 12.45 ± 0.776 a
CoQ10 (10 mg/kg) 16.63 ± 0.639ab 6.36 ± 0.355b
NAC (300 mg/kg) 17.27 ± 0.556ab 7.23 ± 0.480ab
CoQ10 + NAC 13.07 ± 0.582abcd 4.68 ± 0.425bd

Effect of CoQ10, NAC or their combination on body weight% and kidney to body weight ratio (mg/g).

Groups Body weight % Kidney to Body Weight Ratio (mg/g)
Initial at Week 0 Final at Week 12
Control 100.0 ± 0.368 145.2 ± 0.865* 3.807 ± 0.041
STZ-NAD DN 100.0 ±1.389 87.5 ± 0.958a* 7.504 ± 0.193 a
CoQ10 (10 mg/kg) 100.0 ±0.763 105.2 ± 1.122ab* 5.490 ± 0.199ab
NAC (300 mg/kg) 100.0 ±1.128 106.5 ± 0.467ab* 5.201 ± 0.072ab
CoQ10 + NAC 100.0 ±1.039 112.0 ± 1.217abcd* 4.530 ± 0.126abcd

Effect of CoQ10, NAC or their combination on blood glucose level (mg/dL) and HbA1C

Groups Blood Glucose (mg/dL) HbA1C (%)
Initial at Week 0 Final at Week 12
Control 91.83 ± 2.937 91.0 ± 3.13 4.733 ± 0.084
STZ-NAD DN 499.0 ± 17.27a 534.0 ± 24.28a 9.05 ± 0.283 a
CoQ10 (10 mg/kg) 473.2 ± 17.35a 413.5 ± 5.812ab* 6.15 ± 0.080ab
NAC (300 mg/kg) 480.0 ± 15.73a 451.7 ± 11.8ab 6.4 ± 0.085ab
CoQ10 + NAC 477.7 ± 15.34a 351.5 ± 12.03abcd* 5.4 ± 0.171abcd

Effect of CoQ10, NAC or their combination on serum total protein, albumin, creatinine and creatinine clearance.

Groups Total Protein (g/dL) Albumin (g/dL) Creatinine (mg/dL) Creatinine clearance (mL/min)
Control 7.55 ± 0.071 3.65 ± 0.042 0.426 ± 0.032 1.134 ± 0.088
STZ-NAD DN 4.88 ± 0.094a 1.86 ± 0.114 a 2.7 ± 0.182 a 0.269 ± 0.030ab
CoQ10 (10 mg/kg) 6.21 ± 0.149ab 2.95 ± 0.117ab 1.51 ± 0.110ab 0.631 ± 0.039ab
NAC (300 mg/kg) 5.93 ± 0.195ab 2.56 ± 0.133ab 1.55 ± 0.105ab 0.608 ± 0.045ab
CoQ10 + NAC 6.9 ± 0.063abcd 3.05 ± 0.067abd 1.05 ± 0.058abcd 0.907 ± 0.039abcd
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