<abstract xmlns="http://www.w3.org/1999/xhtml">Present research is oriented on the synthesis of some novel 12-(<italic>N</italic>-arylmethaniminyl)indolo[1,2-<italic>c</italic>]quinazoline analogs (4b1–4b11) and their characterization by 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Their free radical scavenging activity and antibacterial potential were also evaluated. Many derivatives have shown a marked free radical scavenging capacity in all the concentrations but specifically compounds 4b7, 4b8 and 4b11 have shown good antioxidant potential with an IC50 value of 25.18 μmol/L, 28.09 μmol/L &amp; 44.22 μmol/L, respectively (DPPH method) and 39.46 μmol/L, 44.47 μmol/L &amp; 35.61 μmol/L, respectively (H2O2 method). The antibacterial evaluation was carried out against <italic>B. subtilis</italic> and <italic>E. coli</italic> by agar well diffusion method and it revealed that all the compounds in the series were having marked antibacterial activity but compounds 4b9 and 4b11 have shown best antibacterial potential. Then, it was concluded that the derivatives which were containing substituted anilines (4-Nitro, 4-Fluoro, 4-Bromo &amp; 4-Chloro-2-nitro) on the carbon attached on the 12th position of indoloquinazoline moiety were having marked potential as an antibacterial and free radical scavenger.</abstract>

Present research is oriented on the synthesis of some novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazoline analogs (4b1–4b11) and their characterization by 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Their free radical scavenging activity and antibacterial potential were also evaluated. Many derivatives have shown a marked free radical scavenging capacity in all the concentrations but specifically compounds 4b7, 4b8 and 4b11 have shown good antioxidant potential with an IC50 value of 25.18 μmol/L, 28.09 μmol/L & 44.22 μmol/L, respectively (DPPH method) and 39.46 μmol/L, 44.47 μmol/L & 35.61 μmol/L, respectively (H2O2 method). The antibacterial evaluation was carried out against B. subtilis and E. coli by agar well diffusion method and it revealed that all the compounds in the series were having marked antibacterial activity but compounds 4b9 and 4b11 have shown best antibacterial potential. Then, it was concluded that the derivatives which were containing substituted anilines (4-Nitro, 4-Fluoro, 4-Bromo & 4-Chloro-2-nitro) on the carbon attached on the 12th position of indoloquinazoline moiety were having marked potential as an antibacterial and free radical scavenger.

Synthesis, antibacterial and free radical scavenging activity of some newer <italic>N</italic>-((10-nitro-1<italic>H</italic>-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, antibacterial and free radical scavenging activity of some newer -((10-nitro-1-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines

Present research is oriented on the synthesis of some novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazoline analogs (4b1–4b11) and their characterization by 1H...

Synthesis, antibacterial and free radical scavenging activity of some newer N-((10-nitro-1H-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines

Article Category: Original Paper

Publié en ligne: 18 nov. 2020

Pages: 7 - 16

Reçu: 20 févr. 2019

Accepté: 11 déc. 2019

DOI: https://doi.org/10.2478/afpuc-2020-0002

Mots clés
free radical scavenger, antibacterial, DPPH, indoloquinazoline, IC

© 2019 Dixit A. et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, antibacterial and free radical scavenging activity of some newer N-((10-nitro-1H-indolo [1, 2-c]quinazolin-12-yl)methylene)benzenamines

Article Category: Original Paper

Publié en ligne: 18 nov. 2020

Pages: 7 - 16

Reçu: 20 févr. 2019

Accepté: 11 déc. 2019

DOI: https://doi.org/10.2478/afpuc-2020-0002

Mots clésfree radical scavenger, antibacterial, DPPH, indoloquinazoline, IC

© 2019 Dixit A. et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
free radical scavenger, antibacterial, DPPH, indoloquinazoline, IC