<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of
scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple
methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated
general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties
of bilayers.</p></abstract>

In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of
scientific results achieved at our University. In this second part, elementary principles of small-angle neutron scattering and simple
methods of scattering data evaluation are described. Results of scattering on bilayers in unilamellar liposomes with intercalated
general anaesthetics, antimicrobials or cholesterol demonstrate the potential of this method at determination of structural properties
of bilayers.

Neutrons in studies of phospholipid bilayers
and bilayer–drug interaction. II. Small-angle scattering

Comenius University in Bratislava, Faculty of Mathematics, Physics and
Informatics, Department of Nuclear Physics and Biophysics, Slovak republic

Comenius University in Bratislava, Faculty of Pharmacy, Department of
Chemical Theory of Drugs, Slovak republic

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In this paper, we demonstrate several possibilities of using neutron scattering in pharmaceutical research based on examples of
scientific results achieved at...

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering

Publié en ligne: 30 déc. 2014

Pages: 12 - 20

DOI: https://doi.org/10.2478/afpuc-2014-0011

Mots clés
neutron scattering, phospholipid liposomes, lipid bilayer, alkanes, alkan-1-ol, cholesterol

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. II. Small-angle scattering

Publié en ligne: 30 déc. 2014

Pages: 12 - 20

DOI: https://doi.org/10.2478/afpuc-2014-0011

Mots clésneutron scattering, phospholipid liposomes, lipid bilayer, alkanes, alkan-1-ol, cholesterol

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
neutron scattering, phospholipid liposomes, lipid bilayer, alkanes, alkan-1-ol, cholesterol