<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives 2a and 2b were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher compared to the ester analogues.</p></abstract>

A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The novel imidazolium bromides were tested as antimicrobial and antifungal agents and their minimal inhibitory concentration (MIC) was evaluated and compared to clinically used benzalkonium bromide (BAB) and carbethopendecinium bromide. The MIC values of amide derivatives 2a and 2b were slightly smaller than those for BAB, indicating their good activity. None of the prepared salts was more effective than carbethopendecinium bromide. The biocidal efficacy of amide derivatives was much higher compared to the ester analogues.

Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts

Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Slovak republic

Comenius University in Bratislava, Faculty of Pharmacy, Department of Cell and Molecular Biology of Drugs, Slovak republic

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A group of homochiral imidazolium salts bearing hydrophobic camphor derived moiety and ester or amide functional group were synthesized and characterized. The...

Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts

Publié en ligne: 30 déc. 2014

Pages: 42 - 48

DOI: https://doi.org/10.2478/afpuc-2014-0007

Mots clés
imidazolium salts, antimicrobial activity, camphorsulfonic acid

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis and antimicrobial properties of camphorsulfonic acid derived imidazolium salts

Publié en ligne: 30 déc. 2014

Pages: 42 - 48

DOI: https://doi.org/10.2478/afpuc-2014-0007

Mots clésimidazolium salts, antimicrobial activity, camphorsulfonic acid

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
imidazolium salts, antimicrobial activity, camphorsulfonic acid