<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders with mainly mild cutaneous manifestations. Some patients with NF1, however, develop severe complications such as progressive optic pathway glioma, plexiform neurofibroma or malignant peripheral nerve sheath tumour. Due to potentially progressive and asymptomatic course of the disease, patients with NF1 require a regular multidisciplinary follow-up in coordination with various specialties and early intervention. In this article, we summarise our long-term experience with multidisciplinary follow-up of NF1 patients in the Centre for Neurofibromatosis Type 1 patients at the Children's University Hospital in Bratislava.</p></abstract>

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders with mainly mild cutaneous manifestations. Some patients with NF1, however, develop severe complications such as progressive optic pathway glioma, plexiform neurofibroma or malignant peripheral nerve sheath tumour. Due to potentially progressive and asymptomatic course of the disease, patients with NF1 require a regular multidisciplinary follow-up in coordination with various specialties and early intervention. In this article, we summarise our long-term experience with multidisciplinary follow-up of NF1 patients in the Centre for Neurofibromatosis Type 1 patients at the Children's University Hospital in Bratislava.

Complex Multidisciplinary Follow-Up Of Children With Neurofibromatosis Type 1

Children's University Hospital Bratislava, 2 Department of Paediatrics, Comenius University in Bratislava, Faculty of Medicine, Bratislava, Slovakia

Slovak Academy of Sciences, Insttute of Molecular Physiology and Genetcs, Bratislava, Slovakia

Children's University Hospital Bratislava, Department of Paediatric Dermatology, Bratislava, Slovakia

Children's University Hospital Bratislava, Department of Paediatric Neurology, Bratislava, Slovakia

Children's University Hospital Bratislava, Department of Paediatric Ophthalmology, Bratislava, Slovakia

Children's University Hospital Bratislava, Department of Paediatric Haematology and Oncology, Slovakia

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Complex Multidisciplinary Follow-Up Of Children With Neurofibromatosis Type 1"}

Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders with mainly mild cutaneous manifestations. Some patients with NF1,...

Complex Multidisciplinary Follow-Up Of Children With Neurofibromatosis Type 1

Article Category: Original research article

Publié en ligne: 30 août 2014

Pages: -

Reçu: 20 févr. 2014

Accepté: 20 avr. 2014

DOI: https://doi.org/10.2478/afpuc-2014-0003

Mots clés
Neurofibromatosis, genetic disorder, variable clinical manifestation, diagnostic criteria, genetic counselling, malignancy, follow-up, broad cooperation with specialists

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Complex Multidisciplinary Follow-Up Of Children With Neurofibromatosis Type 1

Article Category: Original research article

Publié en ligne: 30 août 2014

Pages: -

Reçu: 20 févr. 2014

Accepté: 20 avr. 2014

DOI: https://doi.org/10.2478/afpuc-2014-0003

Mots clésNeurofibromatosis, genetic disorder, variable clinical manifestation, diagnostic criteria, genetic counselling, malignancy, follow-up, broad cooperation with specialists

© Acta Facultatis Pharmaceuticae Universitatis Comenianae

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Neurofibromatosis, genetic disorder, variable clinical manifestation, diagnostic criteria, genetic counselling, malignancy, follow-up, broad cooperation with specialists