<abstract xmlns="http://www.w3.org/1999/xhtml"><p> This article describes a preparation of some new compounds of the aryloxyaminopropanol type derived from 4-hydroxyphenylpropan- 1-one with phenylamino, cyclohexylamino and isobutylamino group in the hydrophilic part and methoxymethyl or ethoxymethyl substituent in the lipophilic part of the molecule. The purity of the prepared compounds was checked by thinlayer chromatography and the structure was confirmed on the basis of interpretation of the IR, UV, 1H NMR and 13C NMR spectra. An enantioseparation of the prepared compounds was performed by using high-performance liquid chromatography on an amylase tris(3,5-dimethylphenylcarbamate) (Chiralpak AD) and native teicoplanin (Chirobiotic T). The chromatographic results such as retention, separation and resolution factors have shown that Chiralpak AD is more suitable for enantioseparation of some of the prepared compounds.</p></abstract>

This article describes a preparation of some new compounds of the aryloxyaminopropanol type derived from 4-hydroxyphenylpropan- 1-one with phenylamino, cyclohexylamino and isobutylamino group in the hydrophilic part and methoxymethyl or ethoxymethyl substituent in the lipophilic part of the molecule. The purity of the prepared compounds was checked by thinlayer chromatography and the structure was confirmed on the basis of interpretation of the IR, UV, 1H NMR and 13C NMR spectra. An enantioseparation of the prepared compounds was performed by using high-performance liquid chromatography on an amylase tris(3,5-dimethylphenylcarbamate) (Chiralpak AD) and native teicoplanin (Chirobiotic T). The chromatographic results such as retention, separation and resolution factors have shown that Chiralpak AD is more suitable for enantioseparation of some of the prepared compounds.

Synthesis of new compounds of the aryloxyaminopropanol type and their HPLC enantioseparation

Comenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Bratislava, Slovak Republic

Slovak University of Technology, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Bratislava, Slovak Republic

European Pharmaceutical Journal

This article describes a preparation of some new compounds of the aryloxyaminopropanol type derived from 4-hydroxyphenylpropan- 1-one with phenylamino,...

Synthesis of new compounds of the aryloxyaminopropanol type and their HPLC enantioseparation

Publié en ligne: 31 déc. 2013

Pages: 37 - 42

DOI: https://doi.org/10.2478/afpuc-2013-0023

Mots clés
aryloxyaminopropanol - enantioseparation - HPLC - Chirobiotic T - Chiralpak AD

This content is open access.

Synthesis of new compounds of the aryloxyaminopropanol type and their HPLC enantioseparation

Publié en ligne: 31 déc. 2013

Pages: 37 - 42

DOI: https://doi.org/10.2478/afpuc-2013-0023

Mots clésaryloxyaminopropanol - enantioseparation - HPLC - Chirobiotic T - Chiralpak AD

This content is open access.

Mots clés
aryloxyaminopropanol - enantioseparation - HPLC - Chirobiotic T - Chiralpak AD