<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of this study was to determine the length of the contraceptive period after the application of deslorelin implant (4.7 mg) in juvenile, prepubertal bitches and assess the effects on the hormonal status (P4, E2 and melatonin), as well as on the occurrence of normal physiological estrus. Twelve crossbred prepubertal female dogs (4 months of age) were divided into the two groups, the treated group (DESLO) and control (placebo) group (C). Hormone assays, vaginal microbiological and cytological smears and the measurements of electrical resistance of cervical mucus were performed once in 3 weeks until the first signs of proestrus, and every day during estrus. GnRH implant significantly postponed time of onset of estrus (633 ± 30,38 days vs. 143.80 ± 52,30 days, P&lt;0.001). In estrus, DESLO group showed statistically higher E2 (34.58 pg/mL vs. 20.59 pg/mL, P&lt;0.001) and melatonin serum concentration (45.86 pg/mL vs. 18.85 pg/mL, P&lt;0.001) compared to the control group. The average P4 serum concentration had no statistically significant differences between groups. In conclusion, deslorelin implants do not cause “flare up” effect in perpubertal bitches, however, increase of E2 and especially melatonin serum concentrations show the need to explore the consequences and mutual influence of melatonin and deslorelin implants in the future.</p>
</abstract>

The aim of this study was to determine the length of the contraceptive period after the application of deslorelin implant (4.7 mg) in juvenile, prepubertal bitches and assess the effects on the hormonal status (P4, E2 and melatonin), as well as on the occurrence of normal physiological estrus. Twelve crossbred prepubertal female dogs (4 months of age) were divided into the two groups, the treated group (DESLO) and control (placebo) group (C). Hormone assays, vaginal microbiological and cytological smears and the measurements of electrical resistance of cervical mucus were performed once in 3 weeks until the first signs of proestrus, and every day during estrus. GnRH implant significantly postponed time of onset of estrus (633 ± 30,38 days vs. 143.80 ± 52,30 days, P<0.001). In estrus, DESLO group showed statistically higher E2 (34.58 pg/mL vs. 20.59 pg/mL, P<0.001) and melatonin serum concentration (45.86 pg/mL vs. 18.85 pg/mL, P<0.001) compared to the control group. The average P4 serum concentration had no statistically significant differences between groups. In conclusion, deslorelin implants do not cause “flare up” effect in perpubertal bitches, however, increase of E2 and especially melatonin serum concentrations show the need to explore the consequences and mutual influence of melatonin and deslorelin implants in the future.

Clinical Use of Long-Term GnRH Agonist in Prepubertal Bitches: Effect on P4, E2 and Melatonin Serum Concentration before and During First Estrus

Faculty of Veterinary Medicine, Department of Reproduction

Faculty of Veterinary Medicine, Department of Economics and Statistics

Acta Veterinaria

This work is licensed under the Creative Commons Attribution 4.0 International License.

The aim of this study was to determine the length of the contraceptive period after the application of deslorelin implant (4.7 mg) in juvenile, prepubertal...

Clinical Use of Long-Term GnRH Agonist in Prepubertal Bitches: Effect on P4, E2 and Melatonin Serum Concentration before and During First Estrus

Article Category: Research article

Publié en ligne: 24 juin 2024

Pages: 273 - 284

Reçu: 25 sept. 2023

Accepté: 08 mai 2024

DOI: https://doi.org/10.2478/acve-2024-0019

Mots clés
deslorelin, estrus, hormonal status, melatonin, prepubertal bitches

© 2024 Vojislav Al Daghistani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Clinical Use of Long-Term GnRH Agonist in Prepubertal Bitches: Effect on P4, E2 and Melatonin Serum Concentration before and During First Estrus

Article Category: Research article

Publié en ligne: 24 juin 2024

Pages: 273 - 284

Reçu: 25 sept. 2023

Accepté: 08 mai 2024

DOI: https://doi.org/10.2478/acve-2024-0019

Mots clésdeslorelin, estrus, hormonal status, melatonin, prepubertal bitches

© 2024 Vojislav Al Daghistani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
deslorelin, estrus, hormonal status, melatonin, prepubertal bitches