<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial influence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family.</p></abstract>

The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear, the pituitary gland and other tissues, and has a substantial influence on the hearing process. Mutations in this gene cause amino acid substitutions in the conserved motor domain of the myosin chain, leading to shortening of the stereocilia in the hair cells, so that the function of myosin XVA is impaired. A research hypothesis was put forth that mutations in the gene responsible for the hearing process in animals of the Canidae family can cause hypoacusis, as well as substantial behavioural changes in dogs (ranging from timidity to aggressive behaviour). The study determined SNP polymorphism in a fragment of the gene MYO15A, which can cause hearing disorders or hypoacusis, in wild and farmed individuals of the Canidae family.

SNP Genetic Diversity Within a Fragment of the Gene Myo15a Responsible for the Hearing Process in a Population of Farmed and Free-Living Animals of the Canidae Family/SNP Genetski Deverzitet U Okviru Fragmenta Gena Myo15a, Odgovornog Za Sluh U Populaciji Životinja Familije Canidae U Uslovima Farmskog I Slobodnog Uzgoja

University of Life Sciences, Faculty of Biology and Animal Breeding, Department of Biological Basis of Animal Production, 20-950 Lublin, Poland

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The gene MYO15A is involved in the production of a protein included in the group of motor proteins known as myosins. Myosin XVA is located in the inner ear,...

Publié en ligne: 03 oct. 2014

Pages: 358 - 366

Reçu: 06 mars 2014

Accepté: 23 avr. 2014

DOI: https://doi.org/10.2478/acve-2014-0034

Mots clés
fox, mutation, MYO15A gene, raccoon dog, SNP haplotype

© by Gryzinska Magdalena

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Publié en ligne: 03 oct. 2014

Pages: 358 - 366

Reçu: 06 mars 2014

Accepté: 23 avr. 2014

DOI: https://doi.org/10.2478/acve-2014-0034

Mots clésfox, mutation, MYO15A gene, raccoon dog, SNP haplotype

© by Gryzinska Magdalena

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
fox, mutation, MYO15A gene, raccoon dog, SNP haplotype