<abstract xmlns="http://www.w3.org/1999/xhtml"> The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this paper we have studied the copper(II) complexes of N-salicyliden-L-glutamate. The photocytostatic effect was monitored against mouse leukemic cell line L1210. Photocytostatic effect was confirmed for [Cu(N-salicyliden-L-glutamato・2H2O]・isoquinoline (CuCIQ), but it wasn’t observed for the parental molecule [Cu(N-salicyliden-L-glutamato・2H2O]・H2O. CuCIQ had photocytotoxic effect already at 10 μM concentration. Irradiated cells (1050 mJ.cm-2, λ = 365 nm) had half the viability of the cells incubated with CuCIQ in the dark (72 h). Co-incubation of the cells with CuCIQ and ascorbic acid increased this photocytotoxic effect and this effect correlated with the elevated level of lipoperoxidation.</abstract>

The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this paper we have studied the copper(II) complexes of N-salicyliden-L-glutamate. The photocytostatic effect was monitored against mouse leukemic cell line L1210. Photocytostatic effect was confirmed for [Cu(N-salicyliden-L-glutamato・2H2O]・isoquinoline (CuCIQ), but it wasn’t observed for the parental molecule [Cu(N-salicyliden-L-glutamato・2H2O]・H2O. CuCIQ had photocytotoxic effect already at 10 μM concentration. Irradiated cells (1050 mJ.cm-2, λ = 365 nm) had half the viability of the cells incubated with CuCIQ in the dark (72 h). Co-incubation of the cells with CuCIQ and ascorbic acid increased this photocytotoxic effect and this effect correlated with the elevated level of lipoperoxidation.

Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline

Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic

Department of Chemical and Biochemical Engineering, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovak Republic

Acta Chimica Slovaca

{"article-title":"Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline"}

The metal complexes have a significant role in photodynamic therapy (PDT). The most common metals studied for PDT of tumors are transitional metals. In this...

Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline

Publié en ligne: 22 mai 2013

Pages: 55 - 59

DOI: https://doi.org/10.2478/acs-2013-0010

Mots clés
photodynamic therapy, photosensitizers, metal complexes, ascorbic acid

This content is open access.

Photocytotoxicity of [Cu(N-salicyliden-L-glutamato · 2H2O] · isoquinoline

Publié en ligne: 22 mai 2013

Pages: 55 - 59

DOI: https://doi.org/10.2478/acs-2013-0010

Mots clésphotodynamic therapy, photosensitizers, metal complexes, ascorbic acid

This content is open access.

Mots clés
photodynamic therapy, photosensitizers, metal complexes, ascorbic acid