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Fingolimod exerts in vitro anticancer activity against hepatocellular carcinoma cell lines via YAP/TAZ suppression

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1. https://gco.iarc.fr/today/home; last access date October 22, 2021. Search in Google Scholar

2. J. M. Llovet, R. K. Kelley, A. Villanueva, A. G. Singal, E. Pikarsky, S. Roayaie, R. Lencioni, K. Koike, J. Zucman-Rossi and R. S. Finn, Hepatocellular carcinoma, Nat. Rev. Dis. Primers 7 (2021) Article ID 6 (28 pages); https://doi.org/10.1038/s41572-020-00240-310.1038/s41572-020-00240-3 Search in Google Scholar

3. A. Villanueva, Hepatocellular carcinoma, N. Engl. J. Med. 380 (2019) 1450–1462; https://doi.org/10.1056/NEJMra171326310.1056/NEJMra1713263 Search in Google Scholar

4. M. Kudo, R. S. Finn, S. Qin, K. H. Han, K. Ikeda, F. Piscaglia, A. Baron, J. W. Park, G. Han, J. Jassem, J. F. Blanc, A. Vogel, D. Komov, T. R. J. Evans, C. Lopez, C. Dutcus, M. Guo, K. Saito, S. Kraljevic, T. Tamai, M. Ren and A. L. Cheng, Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial, Lancet 391 (2018) 1163–1173; https://doi.org/10.1016/S0140-6736(18)30207-110.1016/S0140-6736(18)30207-1 Search in Google Scholar

5. I. M. Moya and G. Halder, Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine, Nat. Rev. Mol. Cell Biol. 20 (2019) 211–226; https://doi.org/10.1038/s41580-018-0086-y10.1038/s41580-018-0086-y30546055 Search in Google Scholar

6. L. Lu, Y. Li, S. M. Kim, W. Bossuyt, P. Liu, Q. Qiu, Y. Wang, G. Halder, M. J. Finegold, J. S. Lee and R. L. Johnson, Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver, Proc. Nat. Acad. Sci USA 107 (2010) 1437–1442; https://doi.org/10.1073/pnas.091142710710.1073/pnas.0911427107282439820080689 Search in Google Scholar

7. H. S. Yoon, K. Fujino, S. Liu, T. Takano and D. Tsugama, NDR/LATS-family protein kinase genes are indispensable for embryogenesis in Arabidopsis, FEBS Open Bio. (2021) 2600–2606; https://doi.org/10.1002/2211-5463.1325710.1002/2211-5463.13257840929034320276 Search in Google Scholar

8. S. H. Patel, F. D. Camargo and D. Yimlamai, Hippo signaling in the liver regulates organ size, cell fate, and carcinogenesis, Gastroenterology 152 (2017) 533–545; https://doi.org/10.1053/j.gastro.2016.10.04710.1053/j.gastro.2016.10.047528544928003097 Search in Google Scholar

9. G. Sorrentino, N. Ruggeri, A. Zannini, E. Ingallina, R. Bertolio, C. Marotta, C. Neri, E. Cappuzzello, M. Forcato, A. Rosato, M. Mano, S. Bicciato and G. Del Sal, Glucocorticoid receptor signalling activates YAP in breast cancer, Nat. Commun. 8 (2017) Article ID 14073 (14 pages); https://doi.org/10.1038/ncomms1407310.1038/ncomms14073525366628102225 Search in Google Scholar

10. M. Z. Xu, T. J. Yao, N. P. Lee, I. O. Ng, Y. T. Chan, L. Zender, S. W. Lowe, R. T. Poon and J. M. Luk, Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma, Cancer 115(19) (2009) 4576–4585; https://doi.org/10.1002/cncr.2449510.1002/cncr.24495281169019551889 Search in Google Scholar

11. S. H. Zhang and D. W. Zhou, Role of the transcriptional coactivators YAP/TAZ in liver cancer, Curr. Opin. Cell Biol. 61 (2019) 64–71; https://doi.org/10.1016/j.ceb.2019.07.00610.1016/j.ceb.2019.07.00631387016 Search in Google Scholar

12. L. Kappos, J. Antel, G. Comi, X. Montalban, P. O’Connor, C. H. Polman, T. Haas, A. A. Korn, G. Karlsson, E. W. Radue and F. D. S. Group, Oral fingolimod (FTY720) for relapsing multiple sclerosis, N. Engl. J. Med. 355 (2006) 1124–1140; https://doi.org/10.1056/NEJMoa05264310.1056/NEJMoa05264316971719 Search in Google Scholar

13. C. White, H. Alshaker, C. Cooper, M. Winkler and D. Pchejetski, The emerging role of FTY720 (Fingolimod) in cancer treatment, Oncotarget 7(17) (2016) 23106-23127; https://doi.org/10.18632/oncotarget.714510.18632/oncotarget.7145502961427036015 Search in Google Scholar

14. P. Dent, L. Booth, J. L. Roberts, A. Poklepovic and J. F. Hancock, Fingolimod augments monomethylfumarate killing of GBM cells, Front. Oncol. 10 (2020) Article ID 22 (15 pages); https://doi.org/10.3389/fonc.2020.0002210.3389/fonc.2020.00022699715232047722 Search in Google Scholar

15. L. Alinari, E. Mahoney, J. Patton, X. Zhang, L. Huynh, C. T. Earl, R. Mani, Y. Mao, B. Yu, C. Quinion, W. H. Towns, C. S. Chen, D. M. Goldenberg, K. A. Blum, J. C. Byrd, N. Muthusamy, M. Praetorius-Ibba and R. A. Baiocchi, FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death, Blood 118(26) (2011) 6893–6903; https://doi.org/10.1182/blood-2011-06-36387910.1182/blood-2011-06-363879356870022042694 Search in Google Scholar

16. G. Marvaso, A. Barone, N. Amodio, L. Raimondi, V. Agosti, E. Altomare, V. Scotti, A. Lombardi, R. Bianco, C. Bianco, M. Caraglia, P. Tassone and P. Tagliaferri, Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro, Cancer Biol. Ther. 15(6) (2014) 797–805; https://doi.org/10.4161/cbt.2855610.4161/cbt.28556404979524657936 Search in Google Scholar

17. N. Zhang, Y. Qi, C. Wadham, L. Wang, A. Warren, W. Di and P. Xia, FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy, Autophagy 6(8) (2010) 1157–1167; https://doi.org/10.4161/auto.6.8.1361410.4161/auto.6.8.1361420935520 Search in Google Scholar

18. M. Qian, F. Yan, W. Wang, J. Du, T. Yuan, R. Wu, C. Zhao, J. Wang, J. Lu, B. Zhang, N. Lin, X. Dong, X. Dai, X. Dong, B. Yang, H. Zhu and Q. He, Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression, Acta Pharm. Sin. B 11(12) (2021) https://doi.org/https://doi.org/10.1016/j.apsb.2021.04.00310.1016/j.apsb.2021.04.003872789435024322 Search in Google Scholar

19. H. Zhu, D. D. Wang, T. Yuan, F. J. Yan, C. M. Zeng, X. Y. Dai, Z. B. Chen, Y. Chen, T. Zhou, G. H. Fan, M. Ying, J. Cao, P. Luo, X. J. Liu, Y. Hu, Y. Peng, Q. He and B. Yang, Multikinase inhibitor CT-707 targets liver cancer by interrupting the hypoxia-activated IGF-1R-YAP Axis, Cancer Res. 78 (2018) 3995–4006; https://doi.org/10.1158/0008-5472.Can-17-154810.1158/0008-5472.CAN-17-154829669759 Search in Google Scholar

20. M. Yu, Z. Peng, M. Qin, Y. Liu, J. Wang, C. Zhang, J. Lin, T. Dong, L. Wang, S. Li, Y. Yang, S. Xu, W. Guo, X. Zhang, M. Shi, H. Peng, X. Luo, H. Zhang, L. Zhang, Y. Li, X. P. Yang and S. Sun, Interferon-gamma induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation, Mol. Cell 81(6) (2021) 1216–1230; https://doi.org/10.1016/j.molcel.2021.01.01010.1016/j.molcel.2021.01.01033606996 Search in Google Scholar

21. H. Zhu, F. Yan, T. Yuan, M. Qian, T. Zhou, X. Dai, J. Cao, M. Ying, X. Dong, Q. He and B. Yang, USP10 Promotes Proliferation of Hepatocellular Carcinoma by DeubiquitiNat.ing and Stabilizing YAP/TAZ, Cancer Res. 80 (2020) 2204–2216; https://doi.org/10.1158/0008-5472.CAN-19-238810.1158/0008-5472.CAN-19-238832217697 Search in Google Scholar

22. G. M. Elisi, M. Santucci, D. D’Arca, A. Lauriola, G. Marverti, L. Losi, L. Scalvini, M. L. Bolognesi, M. Mor and M. P. Costi, Repurposing of drugs targeting YAP-TEAD functions, Cancers (Basel), 10(9) (2018) Article ID 329 (19 pages); https://doi.org/10.3390/cancers1009032910.3390/cancers10090329 Search in Google Scholar

23. D. M. Santos, L. Pantano, G. Pronzati, P. Grasberger, C. K. Probst, K. E. Black, J. J. Spinney, L. P. Hariri, R. Nichols, Y. Lin, M. Bieler, P. Seither, P. Nicklin, D. Wyatt, A. M. Tager and B. D. Medoff, Screening for YAP inhibitors identifies statins as modulators of fibrosis, Am. J. Respir. Cell Mol. Biol. 62(4) (2020) 479–492; https://doi.org/10.1165/rcmb.2019-0296OC10.1165/rcmb.2019-0296OC Search in Google Scholar

24. Y. Liu-Chittenden, B. Huang, J. S. Shim, Q. Chen, S. J. Lee, R. A. Anders, J. O. Liu and D. Pan, Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP, Genes Dev. 26 (2012) 1300–1305; https://doi.org/10.1101/gad.192856.11210.1101/gad.192856.112 Search in Google Scholar

25. K. Vigneswaran, N. H. Boyd, S. Y. Oh, S. Lallani, A. Boucher, S. G. Neill, J. J. Olson and R. D. Read, YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma, Clin. Cancer Res. 27 (2021) 1553–1569; https://doi.org/10.1158/1078-0432.CCR-20-001810.1158/1078-0432.CCR-20-0018 Search in Google Scholar

26. A. V. Pobbati and W. Hong, A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy, Theranostics 10(8) (2020) 3622–3635; https://doi.org/10.7150/thno.4088910.7150/thno.40889 Search in Google Scholar

27. R. Pippa, A. Dominguez, D. J. Christensen, I. Moreno-Miralles, M. J. Blanco-Prieto, M. P. Vitek and M. D. Odero, Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity, Leukemia 28 (2014) 1915–1918; https://doi.org/10.1038/leu.2014.14110.1038/leu.2014.141 Search in Google Scholar

28. T. Zheng, X. Meng, J. Wang, X. Chen, D. Yin, Y. Liang, X. Song, S. Pan, H. Jiang and L. Liu, PTEN-and p53-mediated apoptosis and cell cycle arrest by FTY720 in gastric cancer cells and nude mice, J. Cell Biochem. 111(1) (2010) 218–228; https://doi.org/10.1002/jcb.2269110.1002/jcb.22691 Search in Google Scholar

29. J. M. Woodcock, Y. Ma, C. Coolen, D. Pham, C. Jones, A. F. Lopez and S. M. Pitson, Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function, Cell Signal 22(9) (2010) 1291–1299; https://doi.org/10.1016/j.cellsig.2010.04.00410.1016/j.cellsig.2010.04.004 Search in Google Scholar

30. S. Basu, N. F. Totty, M. S. Irwin, M. Sudol and J. Downward, Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis, Mol. Cell 11(1) (2003) 11–23; https://doi.org/10.1016/s1097-2765(02)00776-110.1016/S1097-2765(02)00776-1 Search in Google Scholar

31. X. Zhao, F. Li and K. Li, The 14-3-3 proteins: regulators of plant metabolism and stress responses, Plant Biol. (Stuttg), 23(4) (2021) 531–539; https://doi.org/10.1111/plb.1326810.1111/plb.1326833811408 Search in Google Scholar

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