Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs

1. World Health Organization, Epilepsy Fact Sheet, WHO, June 2019, Geneve; https://www.who.int/news-room/fact-sheets/detail/epilepsy; last access date October 28, 2020.Search in Google Scholar

2. E. Beghi, The epidemiology of epilepsy, Neuroepidemiology54 (2020) 185–191; https://doi.org/10.1159/00050383110.1159/000503831Search in Google Scholar

3. N. Kuroda, Epilepsy and COVID-19: Associations and important considerations, Epilepsy Behav.108 (2020) Article ID 107122 (3 pages); https://doi.org/10.1016/j.yebeh.2020.10712210.1016/j.yebeh.2020.107122Search in Google Scholar

4. H. P. Rang, M. M. Dall, J. M. Ritter and R. J. Flower, Antiepileptic Drugs, in Rang and Dale’s Pharmacology, Elsevier, Amsterdam 2007, pp. 540–551.10.1016/B978-0-443-06911-6.50045-1Search in Google Scholar

5. R. S. Fisher, W. van Emde Boas, W. Blume, C. Elger, P. Genton, P. Lee and J. Jr. Engel, Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE), Epilepsia46 (2005) 470–472; https://doi.org/10.1111/j.0013-9580.2005.66104.x10.1111/j.0013-9580.2005.66104.xSearch in Google Scholar

6. S. Engelborghs, R. D’Hooge and P. P. De Deyn, Pathophysiology of epilepsy, Acta Neurol. Belg.100 (2000) 201–213.Search in Google Scholar

7. P. Genton, P. Gelisse, P. Thomas and C. Dravet, Do carbamazepine and phenytoin aggravate juvenile myoclonic epilepsy? Neurology55 (2000) 1106–1109; https://doi.org/10.1212/wnl.55.8.110610.1212/WNL.55.8.1106Search in Google Scholar

8. S. C. Schachter, Currently available antiepileptic drugs, Neurotherapeutics4 (2007) 4–11; https://doi.org/10.1016/j.nurt.2006.11.00510.1016/j.nurt.2006.11.005Search in Google Scholar

9. D. G. Vossler, M. Weingarten and B. E. Gidal, Summary of antiepileptic drugs available in the United States of America, Epilepsy Curr. 18 (2018) 1–26; https://doi.org/10.5698/1535-7597.18.4s1.110.5698/1535-7597.18.4s1.1Search in Google Scholar

10. E. Perucca and T. Tomson, The pharmacological treatment of epilepsy in adults, Lancet Neurol.10 (2011) 446–456; https://doi.org/10.1016/S1474-4422(11)70047-310.1016/S1474-4422(11)70047-3Search in Google Scholar

11. D. Schmidt and W. Loscher, Drug resistance in epilepsy, putative neurobiologic and clinical mechanisms, Epilepsia46 (2005) 858–877; https://doi.org/10.1111/j.1528-1167.2005.54904.x10.1111/j.1528-1167.2005.54904.x15946327Search in Google Scholar

12. S. Beyenburg, J. Bauer and M. Reuber, New drugs for the treatment of epilepsy: a practical approach, Postgrad. Med. J.80 (2004) 581–587; https://doi.org/10.1136/pgmj.2004.01997610.1136/pgmj.2004.019976174310715466993Search in Google Scholar

13. S. K. Bhattacharya, G. P. Rauniar and B. P. Das, Recent advances in the management of epilepsy: a review, Kathmandu Univ. Med. J. (KUMJ)3 (2005) 431–437.Search in Google Scholar

14. R. S. Fisher and J. Ho, Potential new methods for antiepileptic drug delivery, CNS Drugs16 (2002) 579–593; https://doi.org/10.2165/00023210-200216090-0000110.2165/00023210-200216090-00001Search in Google Scholar

15. R. S. Fisher and D. K. Chen, New routes for delivery of anti-epileptic medications, Acta Neurol. Taiwan15 (2006) 225–231.Search in Google Scholar

16. J. H. Sampson, M. L. Brady, N. A. Petry, D. Croteau, A. H. Friedman, H. S. Friedman, T. Wong, D. D. D. Bigner, I. Pastan, R. K. K. Puri and C. Pedain, Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning, Neurosurgery60 (2007) ONS-89-ONS-98; https://doi.org/10.1227/01.NEU.0000249256.09289.5F10.1227/01.NEU.0000249256.09289.5FSearch in Google Scholar

17. M. A. Rogawski, Convection-enhanced delivery in the treatment of epilepsy, Neurotherapeutics6 (2009) 344–351; https://doi.org/10.1016/j.nurt.2009.01.01710.1016/j.nurt.2009.01.017Search in Google Scholar

18. A. Van Dycke, R. Raedt, K. Vonck and P. Boon, Local delivery strategies in epilepsy: a focus on adenosine, Seizure20 (2011) 376–382; https://doi.org/10.1016/j.seizure.2011.03.00310.1016/j.seizure.2011.03.003Search in Google Scholar

19. N. Mori, A. Kurokouchi, K. Osonoe, H. Saitoh, K. Ariga, K. Suzuki and Y. Iwata, Liposome-entrapped phenytoin locally suppresses amygdaloid epileptogenic focus created by db-cAMP/EDTA in rats, Brain Res.703 (1995) 184–190; https://doi.org/10.1016/0006-8993(95)01095-510.1016/0006-8993(95)01095-5Search in Google Scholar

20. M. F. Bennewitz and W. M. Saltzman, Nanotechnology for delivery of drugs to the brain for epilepsy, Neurotherapeutics6 (2009) 323–336; https://doi.org/10.1016/j.nurt.2009.01.01810.1016/j.nurt.2009.01.018Search in Google Scholar

21. Y. Malam, E. J. Lim and A. M. Seifalian, Current trends in the application of nanoparticles in drug delivery, Curr. Med. Chem. 18 (2011) 1067–1078; https://doi.org/10.2174/09298671179494086010.2174/092986711794940860Search in Google Scholar

22. M.-H. Hsiao, M. Larsson, A. Larsson, H. Evenbratt, Y.-Y. Chen, Y.-Y. Chen and D.-M. Liu, Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide, J. Control. Release161 (2012) 942–948; https://doi.org/10.1016/j.jconrel.2012.05.03810.1016/j.jconrel.2012.05.038Search in Google Scholar

23. M. D. Farwell, D. J. Chong, Y. Iida, S. A. Bae, B. Easwaramoorthy and M. Ichise, Imaging P-glyco-protein function in rats using [(11) C]-N-desmethyl-loperamide, Ann. Nucl. Med. 27 (2013) 618–24; https://doi.org/10.1007/s12149-013-0725-510.1007/s12149-013-0725-5Search in Google Scholar

24. R. J. Tamargo, L. A. Rossell, E. H. Kossoff, B. M. Tyler, M. G. Ewend and J. J. Aryanpur, The intra-cerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats, Epilepsy Res.48 (2002) 145–155; https://doi.org/10.1016/s0920-1211(01)00330-810.1016/S0920-1211(01)00330-8Search in Google Scholar

25. H. G. Eder, D. B. Jones and R. S. Fisher, Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats, Epilepsia38 (1997) 516–521; https://doi.org/10.1111/j.1528-1157.1997.tb01134.x10.1111/j.1528-1157.1997.tb01134.x9184595Search in Google Scholar

26. M. H. Semreen, A. N. El-Shorbagi, T. H. Al-Tel and I. M. Alsalahat, Targeting γ-aminobutyric acid (GABA) carriers to the brain: potential relevance as antiepileptic pro-drugs, Med. Chem.6 (2010) 144–149; https://doi.org/10.2174/157340641100603014410.2174/157340641100603014420632978Search in Google Scholar

27. A. H. Ropper, Hyperosmolar therapy for raised intracranial pressure, N. Engl. J. Med.367 (2012) 746–752; https://doi.org/10.1056/NEJMct120632110.1056/NEJMct120632122913684Search in Google Scholar

28. A. J. Halliday, S. E. Moulton, G. G. Wallace and M. J. Cook, Novel methods of antiepileptic drug delivery – polymer-based implants, Adv. Drug Deliv. Rev.64 (2012) 953–964; https://doi.org/10.1016/j.addr.2012.04.00410.1016/j.addr.2012.04.00422564384Search in Google Scholar

29. A. Thakker and P. Shanbag, A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures, J. Neurol. 260 (2013) 470–474; https://doi.org/10.1007/s00415-012-6659-310.1007/s00415-012-6659-322983456Search in Google Scholar

30. J. M. Pellock, Safety of diastat, a rectal gel formulation of diazepam for acute seizure treatment, Drug Safety27 (2004) 383–392; https://doi.org/10.2165/00002018-200427060-0000310.2165/00002018-200427060-0000315144232Search in Google Scholar

31. G. J. de Haan, P. van der Geest, G. Doelman, E. Bertram and P. A. Edelbroek, A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations, Epilepsia51 (2010) 478–482; https://doi.org/10.1111/j.1528-1167.2009.02333.x10.1111/j.1528-1167.2009.02333.x19817813Search in Google Scholar

32. A. Okumura, T. Tanabe, T. Kato, F. Hayakawa and K. Watanabe, A pilot study on lidocaine tape therapy for convulsions with mild gastroenteritis, Brain Dev.26 (2004) 525–529; https://doi.org/10.1016/j.braindev.2004.02.00910.1016/j.braindev.2004.02.00915533654Search in Google Scholar

33. K. Mori, H. Ito, Y. Toda, T. Hashimoto, M. Miyazaki, T. Saijo and Y. Kuroda, Successful management of intractable epilepsy with lidocaine tapes and continuous subcutaneous lidocaine infusion, Epilepsia45 (2004) 1287–1290; https://doi.org/10.1111/j.0013-9580.2004.17304.x10.1111/j.0013-9580.2004.17304.x15461684Search in Google Scholar

34. C. Harada, T. Hirai, Y. Fujii, S. Harusawa, T. Kurihara and C. Kamei, Intracerebroventricular administration of histamine H3 receptor antagonists decreases seizures in rat models of epilepsia, Methods Find. Exp. Clin. Pharmacol.26 (2004) 263–270.Search in Google Scholar

35. J. A. Barcia and J. M. Gallego, Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model, Neurotherapeutics6 (2009) 337–343; https://doi.org/10.1016/j.nurt.2009.01.01510.1016/j.nurt.2009.01.015508421219332328Search in Google Scholar

36. M. Yildirim and C. Marangoz, Anticonvulsant effects of focal and intracerebroventricular adenosine on penicillin-induced epileptiform activity in rats, Brain Res.1127 (2006) 193–200; https://doi.org/10.1016/j.brainres.2006.10.02410.1016/j.brainres.2006.10.024Search in Google Scholar

37. A. Misra, S. Ganesh, A. Shahiwala and S. P. Shah, Drug delivery to the central nervous system: a review, J. Pharm. Pharm. Sci.6 (2003) 252–273.Search in Google Scholar

38. J. M. Gonzàlez-Darder, E. Gómez-Cárdenas, M. Guerrero, D. Segura-Pastor and J. L. Gil-Salú, Intrathecal antiepileptic drugs in experimental epilepsy, Stereotact. Funct. Neurosurg.57 (1991) 147–155; https://doi.org/10.1159/00009956610.1159/000099566Search in Google Scholar

39. V. Buonaguro, B. Scelsa, D. Curci, S. Monforte, T. Iuorno and F. Motta, Epilepsy and intrathecal baclofen therapy in children with cerebral palsy, Pediatr. Neurol.33 (2005) 110–113; https://doi.org/10.1016/j.pediatrneurol.2005.03.00210.1016/j.pediatrneurol.2005.03.002Search in Google Scholar

40. V. Riban, H. L. Fitzsimons and M. J. During, Gene therapy in epilepsy, Epilepsia50 (2009) 24–32; https://doi.org/10.1111/j.1528-1167.2008.01743.x10.1111/j.1528-1167.2008.01743.xSearch in Google Scholar

41. M. C. Walker, S. Schorge, D. M. Kullmann, R. C. Wykes, J. H. Heeroma and L. Mantoan, Gene therapy in status epilepticus, Epilepsia54 (2013) 43–45; https://doi.org/10.1111/epi.1227510.1111/epi.12275Search in Google Scholar

42. W. Löscher, M. Gernert and U. Heinemann, Cell and gene therapies in epilepsy – promising avenues or blind alleys? Trends Neurosci.31 (2008) 62–73; https://doi.org/10.1016/j.tins.2007.11.01210.1016/j.tins.2007.11.012Search in Google Scholar

43. A. Mountain, Gene therapy: The first decade, Trends Biotechnol.18 (2000) 119–128; https://doi.org/10.1016/s0167-7799(99)01416-x10.1016/S0167-7799(99)01416-XSearch in Google Scholar

44. M. Simonato, Gene therapy for epilepsy, Epilepsy Behav.38 (2014) 125–130; https://doi.org/10.1016/j.yebeh.2013.09.01310.1016/j.yebeh.2013.09.01324100249Search in Google Scholar

45. G. J. Sills, Novel therapeutic strategies for epilepsy-releasing the gene Genie, Epilepsy Curr.9 (2009) 26–27; https://doi.org/10.1111/j.1535-7511.2008.01280.x10.1111/j.1535-7511.2008.01280.x266811319396346Search in Google Scholar

46. M. Baulac and A. Pitkänen, Research priorities in epilepsy for the next decade – a representative view of the European scientific community, Epilepsia50 (2009) 571–578; https://doi.org/10.1111/j.1528-1167.2008.01811.x10.1111/j.1528-1167.2008.01811.xSearch in Google Scholar

47. D. K. Nguyen and S. S. Spencer, Recent advances in the treatment of epilepsy, Arch Neurol.60 (2003) 929–935; https://doi.org/10.1001/archneur.60.7.92910.1001/archneur.60.7.92912873848Search in Google Scholar

48. Epilepsy Foundation, Seizure Medication List, Landover (MD), September 2010; https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/seizure-medication-list; last access date October 24, 2020Search in Google Scholar

49. Epilepsy Foundation, Epilepsy Pipeline Tracker, Landover (MD), October 2020; https://www.epilepsy.com/pipeline-listing-page; last access date October 22, 2020Search in Google Scholar