<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. This review presents synthetic 2-amino-1,3,4-thiadiazoles exhibiting antitrypanosomal, antimalarial and antitoxoplasmal activities. Although there are insufficient results to state the quality of 2-amino-1,3,4-thiadiazoles as a new class of antiparasitic agents, many reported derivatives can be considered as lead compounds for drug synthesis and a promise for the future treatment of parasitosis and provide a valid strategy for the development of potent antiparasitic drugs.</p></abstract>

Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. This review presents synthetic 2-amino-1,3,4-thiadiazoles exhibiting antitrypanosomal, antimalarial and antitoxoplasmal activities. Although there are insufficient results to state the quality of 2-amino-1,3,4-thiadiazoles as a new class of antiparasitic agents, many reported derivatives can be considered as lead compounds for drug synthesis and a promise for the future treatment of parasitosis and provide a valid strategy for the development of potent antiparasitic drugs.

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses

Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis,...

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses

Publié en ligne: 17 févr. 2020

Pages: 259 - 290

Accepté: 24 oct. 2019

DOI: https://doi.org/10.2478/acph-2020-0031

Mots clés
2-amino-1, 3, 4-thiadiazoles, antiparasitic activity, anti-trypanosomal activity, antimalarial activity, antitoxoplasmal activity, inhibitory concentration

© 2020 Georgeta Serban, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses

Publié en ligne: 17 févr. 2020

Pages: 259 - 290

Accepté: 24 oct. 2019

DOI: https://doi.org/10.2478/acph-2020-0031

Mots clés2-amino-1, 3, 4-thiadiazoles, antiparasitic activity, anti-trypanosomal activity, antimalarial activity, antitoxoplasmal activity, inhibitory concentration

© 2020 Georgeta Serban, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
2-amino-1, 3, 4-thiadiazoles, antiparasitic activity, anti-trypanosomal activity, antimalarial activity, antitoxoplasmal activity, inhibitory concentration