<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.</p></abstract>

Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because they have been established to possess diverse pharmacological potentials. Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Department of Chemistry Covenant University

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless...

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Publié en ligne: 28 mars 2019

Pages: 177 - 196

Accepté: 26 oct. 2018

DOI: https://doi.org/10.2478/acph-2019-0013

Mots clés
quinoxaline, anticancer activity, pharmacophore

© 2019 Olayinka O. Ajani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents

Publié en ligne: 28 mars 2019

Pages: 177 - 196

Accepté: 26 oct. 2018

DOI: https://doi.org/10.2478/acph-2019-0013

Mots clésquinoxaline, anticancer activity, pharmacophore

© 2019 Olayinka O. Ajani et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
quinoxaline, anticancer activity, pharmacophore