Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100

1. G. M. Jantzen and J. R. Robinson, Sustained and Controlled Release Drug Delivery Systems, Marcel Dekker, New York, 1996, pp. 575-610.Search in Google Scholar

2. S. Miyazaki, H. Aoyama, N. Kawasaki, W. Kubo and D. Attwood, In situ-gelling gellan formulations as vehicles for oral drug delivery, J. Control. Release 60 (1999) 287-295; DOI: 10.1016/ S0168-3659(99)00084-X.10.1016/S0168-3659(99)00084-XSearch in Google Scholar

3. S. Miyazaki, W. Kubo and D. Attwood, Oral sustained delivery of theophylline using in situ gelation of sodium alginate, J. Control. Release 67 (2000) 275-280; DOI: 10.1016/s0168-3659(00) 00214-5.Search in Google Scholar

4. S. Miyazaki, N. Kawasaki, W. Kubo, K. Endo and D. Attwood, Comparison of in situ gelling formulations for the oral delivery of cimetidine, Int. J. Pharm. 220 (2001) 161-168; DOI: 10.1016/ S0378-5173(01)00669-X.10.1016/S0378-5173(01)00669-XSearch in Google Scholar

5. W. Kubo, S. Miyazaki and D. Attwood, Oral sustained delivery of paracetamol from in situ- -gelling gellan and sodium alginate formulations, Int. J. Pharm. 258 (2003) 55-64; DOI: 10.1016/ S0378-5173(03)00163-7.10.1016/S0378-5173(03)00163-7Search in Google Scholar

6. D. Schmaljohann, Thermo- and pH-responsive polymers in drug delivery, Adv. Drug Deliv. Rev. 58 (2006) 1655-1670; DOI: 10.1016/j.addr.2006.09.020.10.1016/j.addr.2006.09.02017125884Search in Google Scholar

7. T. Coviello, P. Matricardi, C. Marianecci and F. Alhaique, Polysaccharide hydrogels for modified release formulations, J. Control. Release 119 (2007) 5-24; DOI: S0168-3659(07)00039-9 [pii] 10.1016/j.jconrel.2007.01.004.Search in Google Scholar

8. G. Rohith, B. K. Sridhar and A. Srinatha, Floating drug delivery of a locally acting H2-antagonist: an approach using an in situ gelling liquid formulation, Acta Pharm. 59 (2009) 345-354; DOI: 10.2478/v10007-009-0021-z.10.2478/v10007-009-0021-z19819830Search in Google Scholar

9. L. Rodriguez, O. Caputo, M. Cini, C. Cavallari and R. Grecchi, In vitro release of theophylline from directly-compressed matrices containing methacrylic acid copolymers and/or dicalcium phosphate dehydrate, Farmaco 48 (1993) 1597-1604.Search in Google Scholar

10. L. S. da Fonseca, R. P. Silveira, A.M. Deboni, E. V. Benvenutti, T. M. Costa, S. S. Guterres and A. R. Pohlmann, Nanocapsule@xerogel microparticles containing sodium diclofenac: a new strategy to control the release of drugs, Int. J. Pharm. 358 (2008) 292-295; DOI: S0378-5173(08)00118-X [pii] 10.1016/j.ijpharm.2008.02.005.Search in Google Scholar

11. E. F. Reynolds James, Dextromethorphan Hydrobromide, Royal Pharmaceutical Society, London, 1996, p. 1066.Search in Google Scholar

12. J. L. Bem and R. Peck, Dextromethorphan. An overview of safety issues, Drug Safety 7 (1992) 190-199.10.2165/00002018-199207030-000041503667Search in Google Scholar

13. E. S. Pender and B. R. Parks, Toxicity with dextromethorphan-containing preparations: a literature review and report of two additional cases, Pediatr. Emerg. Care 7 (1991) 163-165.Search in Google Scholar

14. G. M. El Maghraby, Synergistic enhancement of itraconazole dissolution by ternary system formation with pluronic F68 and hydroxypropylmethylcellulose, Sci. Pharm. 77 (2009) 401-417; DOI: 10.3797/scipharm.0901-08.10.3797/scipharm.0901-08Search in Google Scholar

15. F. K. Alanazi, M. El-Badry and I. A. Alsarra, Spray-dried HPMC microparticles of indomethacin impact of drug-polymer ratio and viscosity of the polymeric solution on dissolution, Saudi Pharm. J. 14 (2006) 100-107.Search in Google Scholar

16. G. M. El Maghraby, E. M. Elzayat and F. K. Alanazi, Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan, Drug Dev. Ind. Pharm. (2011); DOI: 10.3109/03639045.2011.634811.10.3109/03639045.2011.63481122092113Search in Google Scholar

17. P. S. Rajinikanth and B. Mishra, Floating in situ gelling system of acetohydroxamic acid for clearance of H. pylori, Drug Dev. Ind. Pharm. 34 (2008) 577-587; DOI: 10.1080/0363904070183181910.1080/0363904070183181918568907Search in Google Scholar

18. K. A. Khan, The concept of dissolution efficiency, J. Pharm. Pharmacol. 27 (1975) 48-49.10.1111/j.2042-7158.1975.tb09378.x235616Search in Google Scholar

19. M. R. Louhaichi, S. Jebali, M. H. Loueslati, N. Adhoum and L. Monser, Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography, Talanta 78 (2009) 991-997; DOI: 10.1016/j.talanta.2009.01.019.10.1016/j.talanta.2009.01.019Search in Google Scholar

20. F. Alanazi, H. Li, D. S. Halpern, S. Oie and D. R. Lu, Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains, Int. J. Pharm. 255 (2003) 189-197; DOI: S0378517303000887.10.1016/S0378-5173(03)00088-7Search in Google Scholar

21. M. Malladi, R. Jukanti, R. Nair, S. Wagh, H. S. Padakanti and A. Mateti, Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets, Acta Pharm. 60 (2010) 267-280; DOI: 10.2478/v10007-010-0025-8.10.2478/v10007-010-0025-8Search in Google Scholar

22. R. P. Raffin, D. Jornada, S. Haas, A. R. Pohlmann and S. S. Guterres, “Pantoprazole sodium loaded controlled release microparticles,” in 15th International Symposium on Microencapsulation, Parma, ed. (Italy, 2005), pp. 7-8.Search in Google Scholar

23. K. H. Kim, M. J. Frank and N. L. Henderson, Application of differential scanning calorimetry to the study of solid drug dispersions, J. Pharm. Sci. 74 (1985) 283-289.10.1002/jps.2600740312Search in Google Scholar

24. R. J. Fessenden and J. S. Fessenden, Fessenden and Fessenden Organic Chemistry, Brooks/Cole publishing company, Pacific Grove, 1990, pp. 323-390. Search in Google Scholar

25. Technical Information on EUDRAGIT L 100 and EUDRAGIT S 100, http://eudragit.evonik.com/product/eudragit/Documents/evonik-specification-eudragit-l-100-and-s-100.pdf; access date January 10, 2011.Search in Google Scholar

26. M. R. Jenquin and J. W. McGinity, Characterization of acrylic resin matrix films and mechanisms of drug-polymer interaction, Int. J. Pharm. 101 (1994) 23-24.10.1016/0378-5173(94)90072-8Search in Google Scholar

27. K. O. R. Lehman, Chemistry and Application Properties of Polymethacrylate Coating Systems, Informa Healthcare USA, Inc., New York, 1990, pp. 101-174.Search in Google Scholar

28. B. J. Lee, J. H. Cui, T. W. Kim, M. Y. Heo and C. K. Kim, Biphasic release characteristics of dual drug-loaded alginate beads, Arch. Pharm. Res. 21 (1998) 645-650.10.1007/BF02976751Search in Google Scholar

29. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci. 50 (1961) 874-875.10.1002/jps.2600501018Search in Google Scholar

30. G. M. Jantzen and J. R. Robinson, Sustained and Controlled Release Drug Delivery Systems, Marcel Dekker, New York, 1996, pp. 575-610.Search in Google Scholar

31. S. Miyazaki, H. Aoyama, N. Kawasaki, W. Kubo and D. Attwood, In situ-gelling gellan formulations as vehicles for oral drug delivery, J. Control. Release 60 (1999) 287-295; DOI: 10.1016/ S0168-3659(99)00084-X.10.1016/S0168-3659(99)00084-XSearch in Google Scholar

32. S. Miyazaki, W. Kubo and D. Attwood, Oral sustained delivery of theophylline using in situ gelation of sodium alginate, J. Control Release 67 (2000) 275-280; DOI: 10.1016/s0168-3659(00)00214-5.10.1016/S0168-3659(00)00214-5Search in Google Scholar

33. S. Miyazaki, N. Kawasaki, W. Kubo, K. Endo and D. Attwood, Comparison of in situ gelling formulations for the oral delivery of cimetidine, Int. J. Pharm. 220 (2001) 161-168; DOI: 10.1016/ S0378-5173(01)00669-X.10.1016/S0378-5173(01)00669-XSearch in Google Scholar

34. W. Kubo, S. Miyazaki and D. Attwood, Oral sustained delivery of paracetamol from in situ- -gelling gellan and sodium alginate formulations, Int. J. Pharm. 258 (2003) 55-64; DOI: 10.1016/ S0378-5173(03)00163-7.10.1016/S0378-5173(03)00163-7Search in Google Scholar

35. D. Schmaljohann, Thermo- and pH-responsive polymers in drug delivery, Adv. Drug Deliv. Rev. 58 (2006) 1655-1670; DOI: 10.1016/j.addr.2006.09.020.10.1016/j.addr.2006.09.020Search in Google Scholar

36. T. Coviello, P. Matricardi, C. Marianecci and F. Alhaique, Polysaccharide hydrogels for modified release formulations, J. Control. Release 119 (2007) 5-24; DOI: S0168-3659(07)00039-9 [pii] 10.1016/j.jconrel.2007.01.004.Search in Google Scholar

37. G. Rohith, B. K. Sridhar and A. Srinatha, Floating drug delivery of a locally acting H2-antagonist: an approach using an in situ gelling liquid formulation, Acta Pharm. 59 (2009) 345-354; DOI: 10.2478/v10007-009-0021-z.10.2478/v10007-009-0021-zSearch in Google Scholar

38. L. Rodriguez, O. Caputo, M. Cini, C. Cavallari and R. Grecchi, In vitro release of theophylline from directly-compressed matrices containing methacrylic acid copolymers and/or dicalcium phosphate dehydrate, Farmaco 48 (1993) 1597-1604.Search in Google Scholar

39. L. S. da Fonseca, R. P. Silveira, A.M. Deboni, E. V. Benvenutti, T. M. Costa, S. S. Guterres and A.Search in Google Scholar

R. Pohlmann, Nanocapsule@xerogel microparticles containing sodium diclofenac: a new strategy to control the release of drugs, Int. J. Pharm. 358 (2008) 292-295; DOI: S0378-5173(08) 00118-X [pii] 10.1016/j.ijpharm.2008.02.005.Search in Google Scholar

40. E. F. Reynolds James, Dextromethorphan Hydrobromide, Royal Pharmaceutical Society, London, 1996, p. 1066.Search in Google Scholar

41. J. L. Bem and R. Peck, Dextromethorphan. An overview of safety issues, Drug Safety 7 (1992) 190-199.10.2165/00002018-199207030-00004Search in Google Scholar

42. E. S. Pender and B. R. Parks, Toxicity with dextromethorphan-containing preparations: a literature review and report of two additional cases, Pediatr. Emerg. Care 7 (1991) 163-165.Search in Google Scholar

43. G. M. El Maghraby, Synergistic enhancement of itraconazole dissolution by ternary system formation with pluronic F68 and hydroxypropylmethylcellulose, Sci. Pharm. 77 (2009) 401-417; DOI: 10.3797/scipharm.0901-08. 10.3797/scipharm.0901-08Search in Google Scholar

44. F. K. Alanazi, M. El-Badry and I. A. Alsarra, Spray-dried HPMC microparticles of indomethacin impact of drug-polymer ratio and viscosity of the Polymeric solution on dissolution, Saudi Pharm. J. 14 (2006) 100-107.Search in Google Scholar

45. G. M. El Maghraby, E. M. Elzayat and F. K. Alanazi, Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan, Drug Dev. Ind. Pharm. (2011); DOI: 10.3109/03639045.2011.634811.10.3109/03639045.2011.634811Search in Google Scholar

46. P. S. Rajinikanth and B. Mishra, Floating in situ gelling system of acetohydroxamic acid for clearance of H. pylori, Drug Dev. Ind. Pharm. 34 (2008) 577-587; DOI: 10.1080/03639040701831819.10.1080/03639040701831819Search in Google Scholar

47. K. A. Khan, The concept of dissolution efficiency, J. Pharm. Pharmacol. 27 (1975) 48-49.10.1111/j.2042-7158.1975.tb09378.xSearch in Google Scholar

48. M. R. Louhaichi, S. Jebali, M. H. Loueslati, N. Adhoum and L. Monser, Simultaneous determination of pseudoephedrine, pheniramine, guaifenesin, pyrilamine, chlorpheniramine and dextromethorphan in cough and cold medicines by high performance liquid chromatography, Talanta 78 (2009) 991-997; DOI: 10.1016/j.talanta.2009.01.019.10.1016/j.talanta.2009.01.019Search in Google Scholar

49. F. Alanazi, H. Li, D. S. Halpern, S. Oie and D. R. Lu, Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains, Int. J. Pharm. 255 (2003) 189-197; DOI: S0378517303000887.10.1016/S0378-5173(03)00088-7Search in Google Scholar

50. M. Malladi, R. Jukanti, R. Nair, S. Wagh, H. S. Padakanti and A. Mateti, Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets, Acta Pharm. 60 (2010) 267-280; DOI: 10.2478/v10007-010-0025-8.10.2478/v10007-010-0025-8Search in Google Scholar

51. R. P. Raffin, D. Jornada, S. Haas, A. R. Pohlmann and S. S. Guterres, Pantoprazole sodiumloaded controlled release microparticles, in 15th International Symposium on Microencapsulation, Parma, ed. (Italy, 2005), pp. 7-8.Search in Google Scholar

52. K. H. Kim, M. J. Frank and N. L. Henderson, Application of differential scanning calorimetry to the study of solid drug dispersions, J. Pharm. Sci. 74 (1985) 283-289.10.1002/jps.2600740312Search in Google Scholar

53. R. J. Fessenden and J. S. Fessenden, Fessenden and Fessenden Organic Chemistry, Brooks/Cole publishing company, Pacific Grove, 1990, pp. 323-390.Search in Google Scholar

54. Technical Information on EUDRAGIT L 100 and EUDRAGIT S 100, http://eudragit.evonik.com/product/eudragit/Documents/evonik-specification-eudragit-l-100-and-s-100.pdf; access date January 10, 2011.Search in Google Scholar

55. M. R. Jenquin and J. W. McGinity, Characterization of acrylic resin matrix films and mechanisms of drug-polymer interaction, Int. J. Pharm. 101 (1994) 23-24.10.1016/0378-5173(94)90072-8Search in Google Scholar

56. K. O. R. Lehman, Chemistry and application properties of polymethacrylate coating systems, Informa Healthcare USA, Inc., New York, 1990, pp. 101-174.Search in Google Scholar

57. B. J. Lee, J. H. Cui, T. W. Kim, M. Y. Heo and C. K. Kim, Biphasic release characteristics of dual drug-loaded alginate beads, Arch Pharm. Res. 21 (1998) 645-650.10.1007/BF029767519868531Search in Google Scholar

58. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci. 50 (1961) 874-875. 10.1002/jps.260050101813907269Search in Google Scholar