<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and bioavailability. This review presents the methods of solid- -state amorphization described in literature (supercooling of liquids, milling, lyophilization, spray drying, dehydration of crystalline hydrates), with the emphasis on milling. Furthermore, we describe how amorphous state of pharmaceuticals differ depending on the method of preparation and how these differences can be screened by a variety of spectroscopic (X-ray powder diffraction, solid state nuclear magnetic resonance, atomic pairwise distribution, infrared spectroscopy, terahertz spectroscopy) and calorimetry methods.</p></abstract>

The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and bioavailability. This review presents the methods of solid- -state amorphization described in literature (supercooling of liquids, milling, lyophilization, spray drying, dehydration of crystalline hydrates), with the emphasis on milling. Furthermore, we describe how amorphous state of pharmaceuticals differ depending on the method of preparation and how these differences can be screened by a variety of spectroscopic (X-ray powder diffraction, solid state nuclear magnetic resonance, atomic pairwise distribution, infrared spectroscopy, terahertz spectroscopy) and calorimetry methods.

Methods of amorphization and investigation of the amorphous state

University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia

Acta Pharmaceutica

{"article-title":"Methods of amorphization and investigation of the amorphous state"}

The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and...

Methods of amorphization and investigation of the amorphous state

Publié en ligne: 22 oct. 2013

Pages: 305 - 334

DOI: https://doi.org/10.2478/acph-2013-0026

Mots clés
amorphous solid preparation, crystallinity, spectroscopy, calorimetry

This content is open access.

Methods of amorphization and investigation of the amorphous state

Publié en ligne: 22 oct. 2013

Pages: 305 - 334

DOI: https://doi.org/10.2478/acph-2013-0026

Mots clésamorphous solid preparation, crystallinity, spectroscopy, calorimetry

This content is open access.

Mots clés
amorphous solid preparation, crystallinity, spectroscopy, calorimetry