Formulation and optimization of fenofibrate lipospheres using Taguchi’s experimental design

1. G. Fricker, T. Kromp, A. Wendel, A. Blume, J. Zirkel, H. Rebmann, C. Setzer, R. O. Quinkert, F. Martin and C. M. Goymann, Phospholipids and lipid-based formulations in oral drug delivery, Pharm. Res. 27 (2010) 1469-1486; DOI: 10.1007/s11095-010-0130-x.10.1007/s11095-010-0130-xSearch in Google Scholar

2. Y. C. Tseng, Y. Tabata, S. H. Hyon and Y. Ikada, In vitro toxicity test of 2 cyanoacrylate polymers by cell culture method, J. Biomed. Mater. Res. A 24 (1990) 1355-1367; DOI: 10.1002/jbm.820241007.10.1002/jbm.820241007Search in Google Scholar

3. K. Lam, J. Schakenraad, H. Esselbrugge, J. Feijen and P. Nieuwenhuis, The effect of phagocytosis of poly(L -lactic acid) fragments on cellular morphology and viability, J. Biomed. Mater. Res. A27 (1993) 1569-1577; DOI: 10.1002/jbm.820271214.10.1002/jbm.820271214Search in Google Scholar

4. D. B. Masters and A. J. Domb, Liposphere local anesthetic timed-release for perineural site application, Pharm. Res. 15 (1998) 1038-1045; DOI: 10.1023/A:1011978010724.10.1023/A:1011978010724Search in Google Scholar

5. S. Toongsuwan, L. C. Li, B. K. Erickson and H. C. Chang, Formulation and characterization of bupivacaine lipospheres, Int. J. Pharm. 280 (2004) 57-65; DOI: 10.1016/j.bbr.2011.03.031.10.1016/j.bbr.2011.03.031Search in Google Scholar

6. A. J. Domb, Long acting injectable oxytetracycline-liposphere formulations, Int. J. Pharm. 124 (1995) 271-278; DOI: 10.1016/0378-5173(95)00098-4.10.1016/0378-5173(95)00098-4Search in Google Scholar

7. B. Amarji, D. Raghuwanshi, S. Vyas and P. Kanaujia, Lipid nano spheres (LNSs) for enhanced oral bioavailability of amphotericin B: development and characterization, J. Biomed. Nanotechnol.3 (2007) 264-269; DOI: 10.1166/jbn.2007.029.10.1166/jbn.2007.029Search in Google Scholar

8. A. Bhatia, B. Singh, V. Rani and O. Katare, Formulation, characterization, and evaluation of benzocaine phospholipid-tagged lipospheres for topical application, J. Biomed. Nanotechnol. 3 (2007) 81-89; DOI: 10.1166/jbn.2007.009.10.1166/jbn.2007.009Search in Google Scholar

9. T. Bekerman, J. Golenser and A. Domb, Cyclosporin nanoparticulate lipospheres for oral administration, J. Pharm. Sci. 93 (2004) 1264-1270; DOI: 10.1002/jps.20057.10.1002/jps.2005715067702Search in Google Scholar

10. N. Sateeshbabu and K. Gowthamarajan, Manufacturing techniques of lipospheres: overview, Int. J. Pharm. Pharm. Sci. 3 (2011) 17-21.Search in Google Scholar

11. United States Pharmacopoeia XXXI, National Formulary XXVI, USP Convention, Rockville (MD) 2008, pp. 2145-2146.Search in Google Scholar

12. J. J. Sheng, P. J. Sirois, J. B. Dressman and G. L. Amidon, Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed, J. Pharm. Sci. 97 (2008) 4815-4829; DOI: 10.1002/jps.21345.10.1002/jps.2134518314890Search in Google Scholar

13. T. Higuchi, Mechanisms of sustained action medications: theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci. 52 (1963) 1145-1149; DOI: 10.1002/jps. 2600521210.Search in Google Scholar

14. R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri and N. A. Peppas, Mechanisms of solute release from porous hydrophilic polymers, Int. J. Pharm. 15 (1983) 25-35; DOI: 10.1016/0378-5173(83) 90064-9.Search in Google Scholar

15. P. Röeschlau, E. Bernt and W. Gruber, Enzymatic determination of total cholesterol in serum, Z. Klin. Chem. Klin. Biochem. 12 (1974) 403-407.Search in Google Scholar

16. P. Fossati and L. Prencipe, Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide, Clin. Chem. 28 (1982) 2077-2080.10.1093/clinchem/28.10.2077Search in Google Scholar

17. K. D. Kim, D. N. Han and H. T Kim, Optimization of experimental conditions based on the Taguchi robust design for the formation of nano-sized silver particles by chemical reduction method, Chem. Eng. J. 104 (2004) 55-61; DOI: 10.1016/j.cej.2004.08.003.10.1016/j.cej.2004.08.003Search in Google Scholar

18. L. Mu and S. S. Feng, Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly(lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers, J. Control. Release 76 (2001) 239-254; DOI: 10.1016/S0168-3659(01)00440-0.10.1016/S0168-3659(01)00440-0Search in Google Scholar

19. A. Dubey, P. Prabhu and J. V. Kamath, Nano structured lipid carriers: A novel topical drug delivery system, Int. J. Pharm. Tech. Res. 4 (2012) 705-714.Search in Google Scholar

20. M. Nasr, S. Mansour, N. D. Mortada and A. El. Shamy, Lipospheres as carriers for topical delivery of aceclofenac: Preparation, characterization and in vivo evaluation, AAPS PharmSciTech. 9 (2008) 154-162; DOI: 10.1208/s12249-007-9028-2.10.1208/s12249-007-9028-2297689618446476Search in Google Scholar

21. M. Ozyazici, E. H. Gokçe and G. Ertan, Release and diffusional modeling of metronidazole lipidmatrices, Eur. J. Pharm. Biopharm. 63 (2006) 331-339; DOI: 10.1016/j.ejpb.2006.02.005. 10.1016/j.ejpb.2006.02.00516621486Search in Google Scholar