<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Nasal nitric oxide (nNO), discovered in exhaled air in 1991, is produced in the nose and paranasal sinuses. This small gaseous molecule plays various roles in the organism, e.g. the first line defense through its antiviral and antimicrobial activity, stimulation of ciliary motility, regulation of pulmonary function. The measurement of nNO has become a diagnostic tool in various diagnoses, such as primary ciliary dyskinesia, allergic rhinitis, chronic rhinosinusitis, and others. In this article, we discuss the potential benefit of nNO measurement in diagnosis and monitoring of various respiratory diseases.</p>
</abstract>

Nasal nitric oxide (nNO), discovered in exhaled air in 1991, is produced in the nose and paranasal sinuses. This small gaseous molecule plays various roles in the organism, e.g. the first line defense through its antiviral and antimicrobial activity, stimulation of ciliary motility, regulation of pulmonary function. The measurement of nNO has become a diagnostic tool in various diagnoses, such as primary ciliary dyskinesia, allergic rhinitis, chronic rhinosinusitis, and others. In this article, we discuss the potential benefit of nNO measurement in diagnosis and monitoring of various respiratory diseases.

Is Nasal Nitric Oxide Measurement an Useful Diagnostic Tool in Respiratory Diseases?

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Nasal nitric oxide (nNO), discovered in exhaled air in 1991, is produced in the nose and paranasal sinuses. This small gaseous molecule plays various roles in...

Diagnosis	nNO values (ppb)	Healthy controls	Study
PCD	64±36.6	759±145.8	Wodehouse et al, 2003
Allergic rhinitis	939 ± 335	–	Liu et al., 2020
UACS with sinusitis	190.1 ± 114.8	334.9 ± 88.2	Kim et al., 2011
UACS without sinusitis	345.7 ± 114.6	334.9 ± 88.2	Kim et al., 2011
OSAS before sleep	487.03 ± 115.83	413.37 ± 73.10	Zhang et al., 2019
OSAS after sleep	550.07 ± 130.24	460.43 ± 109.7	Zhang et al., 2019
Adenoid hypertrophy gr. 1	814 (median)	1050 (median)	Chladkova et al., 2015
Adenoid hypertrophy gr. 2	728 (median)	1050 (median)	Chladkova et al., 2015
Adenoid hypertrophy gr. 3	539 (median)	1050 (median)	Chladkova et al., 2015

Is Nasal Nitric Oxide Measurement an Useful Diagnostic Tool in Respiratory Diseases?

Publié en ligne: 20 avr. 2023

Pages: 8 - 14

Reçu: 12 déc. 2022

Accepté: 08 févr. 2023

DOI: https://doi.org/10.2478/acm-2023-0002

© 2023 Lucanska M. et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

nNO values according to diagnoses compared with healthy controls