Upper Gastrointestinal Visceral Pain Models in Guinea-Pigs (Mini-Review)

1. Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N. Development, plasticity and modulation of visceral afferents. Brain Res Rev. 2009;60(1):171-86.10.1016/j.brainresrev.2008.12.004Search in Google Scholar

2. Gold MS, Gebhart GF. Nociceptor sensitization in pain pathogenesis. Nat Med. 2010 Nov;16(11):1248-57.10.1038/nm.2235Search in Google Scholar

3. Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci. 2000 Dec 20;85(1-3):1-1710.1016/S1566-0702(00)00215-0Search in Google Scholar

4. Cervero F. Sensory Innervation of the Viscera: Peripheral Basis of Visceral Pain. Physiol Rev. 1994 Jan;74(1):95-13810.1152/physrev.1994.74.1.95Search in Google Scholar

5. Ness TJ, Gebhart GF. Visceral pain: a review experimental studies. Pain. 1990 May;41(2):167-234.10.1016/0304-3959(90)90021-5Search in Google Scholar

6. DeVault KR, Beacham S, Castell DO, Streletz LJ, Ditunno JF. Esophageal sensation in spinal cord-injured patients: balloon distension and cerebral evoked potential recording. Am J Physiol. 1996 Dec;271(6 Pt 1):G937-41.10.1152/ajpgi.1996.271.6.G9378997236Search in Google Scholar

7. Levinthal DJ, Bielefeldt K. Pain without nociception? Eur J Gastroenterol Hepatol. 2012 Mar;24(3):336-9.10.1097/MEG.0b013e32834fbf5b22266836Search in Google Scholar

8. Yu S, Undem BJ, Kollarik M. Vagal afferent nerves with nociceptive properties in guinea- pig oesophagus. J Physiol 2005;563(Pt 3):831-42.10.1113/jphysiol.2004.079574166560315649987Search in Google Scholar

9. Kollarik M, Ru F, Undem BJ. Acid-sensitive vagal sensory pathways and cough. Pulm Pharmacol Ther 2007; 20: 402-411.10.1016/j.pupt.2006.11.010257716817289409Search in Google Scholar

10. Furuta S, Shimizu T, Narita M, Matsumoto K, Kuzumaki N, Horie S, Suzuki T, Narita M. Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. Neuroscience. 2009 Dec 15;164(3):1252-62.10.1016/j.neuroscience.2009.09.02119772896Search in Google Scholar

11. Sakurai J et al.. Activation of Extracellular Signal-Regulated Protein Kinase in Sensory Neurons After Noxious Gastric Distention and Its Involvement in Acute Visceral Pain in Rats. Gastroenterology 2008;134:1094-1103.10.1053/j.gastro.2008.01.031Search in Google Scholar

12. Ozaki N, Bielefeldt K, Sengupta JN, Gebhart GF. Models of gastric hyperalgesia in the rat. Am J Physiol Gastrointest Liver Physiol 283:666-676, 2002.10.1152/ajpgi.00001.2002Search in Google Scholar

13. Lamb K, Kang YM, Gebhart GF, Bielefeldt K. Gastric inflammation triggers hypersensitivity to acid in awake rats. Gastroenterology 2003;125:1410-1418.10.1016/j.gastro.2003.07.010Search in Google Scholar

14. Fioramonti J, Gebhart GF. In vivo and transgenic animal models used to study visceral hypersensitivity. Neurogastroenterol Motil. 2007 Jan;19(1 Suppl):20-8.10.1111/j.1365-2982.2006.00872.xSearch in Google Scholar

15. Kollarik M, Carr MJ, Ru F, Ring CJ, Hart VJ, Murdock P, Myers AC, Muroi Y, Undem BJ. Transgene expression and effective gene silencing in vagal afferent neurons in vivo using recombinant adeno-associated virus vectors. J Physiol. 2010 Nov 1;588(Pt 21):4303-15.10.1113/jphysiol.2010.192971Search in Google Scholar

16. Westlund KN. Animal models of visceral pain. In: Chao Ma and Jun-Ming Zhang (eds.), Animal Models of Pain, Neuromethods, vol. 49 Humana Press 1st Edition. edition (October 11, 2010). p 41-68.10.1007/978-1-60761-880-5_3Search in Google Scholar

17. Jones RCW. Models of Visceral Pain: Colorectal Distension (CRD). Current Protocols in Pharmacology. Online Posting Date: September, 2004 Sep 1;Chapter 5:Unit 5.36.Search in Google Scholar

18. Miwa H, Oshima T, Sakurai J, Tomita T, Matsumoto T, Iizuka S, Koseki J. Experimental oesophagitis in the rat is associated with decreased voluntary movement. Neurogastroenterol Motil. 2009 Mar;21(3):296-303.10.1111/j.1365-2982.2008.01221.xSearch in Google Scholar

19. Kurejova M, Nattenmuller U, Hildebrandt U, Selvaraj D, Strosser S, Kuner R. An improved behavioural assay demonstrates that ultrasound vocalizations constitute a reliable indicator of chronic cancer pain and neuropathic pain. Mol Pain. 2010 Mar 26;6:18.10.1186/1744-8069-6-18Search in Google Scholar

20. Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods. 1989 Sep;29(3):261-5.10.1016/0165-0270(89)90150-7Search in Google Scholar

21. Westlund KN, Vera-Portocarrero LP, Zhang L, Wei J, Quast MJ, Cleeland CS. fMRI of supraspinal areas after morphine and one week pancreatic inflammation in rats. Neuroimage. 2009 Jan 1;44(1):23-34.10.1016/j.neuroimage.2008.07.048259309018722538Search in Google Scholar

22. Keating SC, Thomas AA, Flecknell PA, Leach MC. Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioural and facial expression responses. PLoS One. 2012;7(9):e44437.10.1371/journal.pone.0044437Search in Google Scholar

23. Banner SE, Sanger GJ. Differences between 5-HT3 receptor antagonists in modulation of visceral hypersensitivity. Br J Pharmacol 1995; 114: 558-62.10.1111/j.1476-5381.1995.tb13263.xSearch in Google Scholar

24. Nijsen MJ, Ongenae NG, Coulie B, Meulemans AL. Telemetric animal model to evaluate visceral pain in the freely moving rat. Pain. 2003 Sep;105(1-2):115-23.10.1016/S0304-3959(03)00170-2Search in Google Scholar

25. Haycox A, Einarson T, Eggleston A. The health economic impact of upper gastrointestinal symptoms in the general population: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl 1999; 231: 38-47.10.1080/00365529975002525510565622Search in Google Scholar

26. Sherrington SC. The integrative action of the nervous system. New Haven: Yale University Press; 1906.Search in Google Scholar