<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This retrospective study aims to analyze the relationship between biochemical changes occurring in newborns with sepsis proven by positive blood culture (BC) and possible correlations with 1 min Apgar score, 5 min Apgar score, gestational age (GA), and birth weight (BW). We included in the study all infants ≤7 days of life with positive BC that were admitted to the Neonatal Intensive Care Unit (NICU) and Neonatology Department (ND) of the County Emergency Clinical Hospital of Târgu Mureş, a tertiary level hospital, between 2014-2018. The analyzed parameters are: day of life for blood sampling (0-7 days of life), gender, Apgar score (1 and 5 minute), GA, BW, urea, creatinine, total bilirubin, direct bilirubin, aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), c-reactive protein (CPR), bacteria involved, empiric antibiotics administered before blood sampling, temperature of the newborn on the day of BC. We found there is a statistically significant negative correlation between 1 and 5 min Apgar score and creatinine, between GA and urea and also between BW, GA and Direct Bilirubin. We found a statistically significant positive correlation between BW, GA and GPT.</p></abstract>

This retrospective study aims to analyze the relationship between biochemical changes occurring in newborns with sepsis proven by positive blood culture (BC) and possible correlations with 1 min Apgar score, 5 min Apgar score, gestational age (GA), and birth weight (BW). We included in the study all infants ≤7 days of life with positive BC that were admitted to the Neonatal Intensive Care Unit (NICU) and Neonatology Department (ND) of the County Emergency Clinical Hospital of Târgu Mureş, a tertiary level hospital, between 2014-2018. The analyzed parameters are: day of life for blood sampling (0-7 days of life), gender, Apgar score (1 and 5 minute), GA, BW, urea, creatinine, total bilirubin, direct bilirubin, aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), c-reactive protein (CPR), bacteria involved, empiric antibiotics administered before blood sampling, temperature of the newborn on the day of BC. We found there is a statistically significant negative correlation between 1 and 5 min Apgar score and creatinine, between GA and urea and also between BW, GA and Direct Bilirubin. We found a statistically significant positive correlation between BW, GA and GPT.

Biochemical Changes Occuring in Neonates with Sepsis

Clinical Laboratory of County Emergency Clinical Hospital of Tîrgu Mureș

, University of Medicine, Pharmacy, Science and Technology of Tîrgu Mureș

Department of Microbiology, Virology, Parasitology

University of Medicine, Pharmacy, Science and Technology of Tîrgu Mureș

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Biochemical Changes Occuring in Neonates with Sepsis"}

This retrospective study aims to analyze the relationship between biochemical changes occurring in newborns with sepsis proven by positive blood culture (BC)...

Biochemical Changes Occuring in Neonates with Sepsis

Publié en ligne: 24 sept. 2019

Pages: 30 - 37

Reçu: 20 juin 2019

Accepté: 25 juin 2019

DOI: https://doi.org/10.2478/abmj-2019-0004

Mots clés
neonate, septicemia, bacteremia, biochemistry, CRP

© 2019 Irina-Bianca Kosovski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biochemical Changes Occuring in Neonates with Sepsis

Publié en ligne: 24 sept. 2019

Pages: 30 - 37

Reçu: 20 juin 2019

Accepté: 25 juin 2019

DOI: https://doi.org/10.2478/abmj-2019-0004

Mots clésneonate, septicemia, bacteremia, biochemistry, CRP

© 2019 Irina-Bianca Kosovski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
neonate, septicemia, bacteremia, biochemistry, CRP