Age (quartile) | >32, >35, 13, 14 | 0.65 |
Gender (male vs. female) | 8 vs. >32 | 0.01 |
HIV infection (yes vs. no) | 14 vs. >21 | 0.79 |
Hematologic malignancies (yes vs. no) | 5 vs. 16 | 0.21 |
Diabetes mellitus (yes vs. no) | 10 vs. 14 | 0.51 |
Cryptococcosis (yes vs. no) | 16 vs. 5 | 0.11 |
Concomitant nephrotoxics (yes vs. no) | 16 vs. 13 | 0.78 |
Body weight (quartile) | 17, >35, 14, 5 | 0.06 |
Dose of AmBd (quartile) | >21, 10, 16, 5 | 0.40 |
NSS/BW (quartile) | 6, 14, >35, 17 | 0.09 |
NSS/AmBd (quartile) | 5, 14, 17, >21 | 0.03 |
Baseline BUN (quartile) | 8, 6, 14, >35 | 0.04 |
Baseline Cr (quartile) | 14, 10, 7, 18 | 0.87 |
Baseline CKD-EPI eGFR (quartile) | 18, 20, 13, 6 | 0.17 |
Baseline BUN/Cr ratio (quartile) | 5, 7, 16, 18 | 0.09 |
Baseline sodium (quartile) | 16, 8, >21, 6 | 0.25 |
Baseline potassium (quartile) | 13, 16, >35, 8 | 0.45 |
Baseline chloride (quartile) | 6, 13, 9, 17 | 0.35 |
Baseline bicarbonate (quartile) | 18, 14, 5, 6 | 0.04 |
Baseline magnesium (quartile) | 10, 18, 13, 6 | 0.67 |
Gender | |
Male | 37.2 |
Female | 63.1 |
NSS/AmBd (mL/mg) | |
<10 |
15.6 |
10–11 | 44.9 |
11.1–14.2 | 54.2 |
>14.2 |
61.4 |
Baseline BUN (mg/dL) | |
<9 | 36.4 |
9–12 |
29.4 |
13–15 | 47.6 |
>15 |
73.4 |
Baseline bicarbonate (mEq/L) | |
<21 |
65.7 |
21–22 | 47.3 |
23–24 |
34.1 |
>24 | 40.7 |
Age (years) | 40.3 ± 13.8 |
Female gender | 27 (45.0%) |
Comorbidity | |
HIV infection | 41 (68.3%) |
Hematologic malignancies | 10 (16.7%) |
Diabetes mellitus | 2 (3.3%) |
Fungal infection | |
Cryptococcosis | 46 (76.7%) |
Aspergillosis | 14 (23.3%) |
Concomitant use of nephrotoxic drugs | |
Amikacin | 2 (3.3%) |
Vancomycin | 5 (8.3%) |
Tenofovir disoproxil fumarate | 4 (6.7%) |
Body weight (kg) | 50.3 ± 10.8 |
Dose of AmBd (mg/kg/d) | 0.90 ± 0.15 |
Duration of AmBd therapy (d) | 14 (7–20) |
Dose of NSS pre-infusion | |
(a) Adjusted to body weight, NSS/BW (mL/kg BW) | 10.5 ± 2.0 |
(b) Adjusted to AmBd dose, NSS/AmBd (mL/mg AmBd) | 11.9 ± 3.0 |
Baseline BUN (mg/dL) | 12.8 ± 5.3 |
Baseline Cr (mg/dL) | 0.77 ± 0.21 |
Baseline CKD-EPI eGFR (mL/min/1.73 m2) | 106.3 ± 23.1 |
Baseline BUN/Cr ratio | 17.3 ± 7.4 |
Baseline sodium (mEq/L) | 132.5 ± 5.6 |
Baseline potassium (mEq/L) | 3.90 ± 0.43 |
Baseline chloride (mEq/L) | 99.0 ± 5.7 |
Baseline bicarbonate (mEq/L) | 22.6 ± 3.6 |
Baseline magnesium (mg/dL), incomplete data (n = 40) | 0.79 ± 0.14 |
Acute kidney injury | 31 (51.7%) |
Gender | – | 0.02 | 0.07 | 0.08 |
NSS/AmBd (quartile) | 0.04 | – | 0.03 | 0.02 |
BUN (quartile) | 0.02 | 0.01 | – | 0.04 |
Bicarb (quartile) | 0.18 | 0.04 | 0.36 | – |