<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Statins are the most widely used lipid-lowering agents for patients with hyperlipidemia. However, interindividual variations in efficacy and risk of adverse drug reactions to statin treatment have been widely reported. Ethnicity is well known to be one of the contributing factors to this variation, particularly among Asians.</p>
</sec>
<sec><h3>Objectives</h3>
<p>To identify genetic variants associated with statin treatment responses among Asian populations with a focus on four commonly prescribed statins: atorvastatin, rosuvastatin, simvastatin, and pravastatin.</p>
</sec>
<sec><h3>Methods</h3>
<p>A literature search was conducted in Medline and Embase databases. Studies published from 2008 to 2021 were included. The title and abstract of each article were screened by two reviewers and verified by another two reviewers. Data charted include information on authors, year of study, study population, statin studied, gene studied, study findings, and data of significant statistical value.</p>
</sec>
<sec><h3>Results</h3>
<p>A total of 35 articles were included from the 1,939 original studies related to treatment efficacy and 5 articles out of the 284 original studies related to adverse effects. Genetic variants in transmembrane transporters, cytochrome P450 isoenzymes, and apolipoproteins are the most extensively studied among Asian populations, with a main focus on ethnic Chinese. However, Asia consists of genetically different populations, and the results of this review indicated that there is a paucity of studies on other ethnic groups within Asia.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>Considering the ethnicity of patients could provide a potential value to personalized medicine in statin therapy.</p>
</sec>
</abstract>

Background
Statins are the most widely used lipid-lowering agents for patients with hyperlipidemia. However, interindividual variations in efficacy and risk of adverse drug reactions to statin treatment have been widely reported. Ethnicity is well known to be one of the contributing factors to this variation, particularly among Asians.

Objectives
To identify genetic variants associated with statin treatment responses among Asian populations with a focus on four commonly prescribed statins: atorvastatin, rosuvastatin, simvastatin, and pravastatin.

Methods
A literature search was conducted in Medline and Embase databases. Studies published from 2008 to 2021 were included. The title and abstract of each article were screened by two reviewers and verified by another two reviewers. Data charted include information on authors, year of study, study population, statin studied, gene studied, study findings, and data of significant statistical value.

Results
A total of 35 articles were included from the 1,939 original studies related to treatment efficacy and 5 articles out of the 284 original studies related to adverse effects. Genetic variants in transmembrane transporters, cytochrome P450 isoenzymes, and apolipoproteins are the most extensively studied among Asian populations, with a main focus on ethnic Chinese. However, Asia consists of genetically different populations, and the results of this review indicated that there is a paucity of studies on other ethnic groups within Asia.

Conclusions
Considering the ethnicity of patients could provide a potential value to personalized medicine in statin therapy.

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review

Department of Pharmaceutical Life Sciences, Faculty of Pharmacy

School of Pharmacy, Faculty of Health and Medical Sciences

Medical Advancement for Better Quality of Life Impact Lab

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
Statins are the most widely used lipid-lowering agents for patients with hyperlipidemia. However, interindividual variations in efficacy and risk of...

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review

Article Category: Review

Publié en ligne: 09 oct. 2023

Pages: 95 - 114

DOI: https://doi.org/10.2478/abm-2023-0050

Mots clés
cholesterol, HMG-CoA reductase inhibitors, HMG-CoA statins, myotoxicity, pharmacogenomics

© 2023 Hui-Yin Yow et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review

Article Category: Review

Publié en ligne: 09 oct. 2023

Pages: 95 - 114

DOI: https://doi.org/10.2478/abm-2023-0050

Mots cléscholesterol, HMG-CoA reductase inhibitors, HMG-CoA statins, myotoxicity, pharmacogenomics

© 2023 Hui-Yin Yow et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
cholesterol, HMG-CoA reductase inhibitors, HMG-CoA statins, myotoxicity, pharmacogenomics