Accès libre

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

Jiansheng Zheng
Jiansheng Zheng
 et 
Tang Zhu
Tang Zhu
   | 17 sept. 2023
Asian Biomedicine's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Article Category: Review
Publié en ligne: 17 sept. 2023
Pages: 45 - 54
DOI: https://doi.org/10.2478/abm-2023-0044
Mots clés
© 2023 Jiansheng Zheng et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1.

Study selection flow diagram describing the screening process. FUT3, fucosyltransferase 3 gene; IBD, inflammatory bowel disease.
Study selection flow diagram describing the screening process. FUT3, fucosyltransferase 3 gene; IBD, inflammatory bowel disease.

Figure 2.

Forest plots of meta-analysis of the genotypes of rs3745635 and IBD. The odds ratios and 95% CIs of the 1712 patients with IBD with GA + AA vs GG rs3745635 genotype and the 1903 controls from 5 articles (A), the 1654 patients with IBD with GG + GA vs AA rs3745635 genotype and the 1843 controls from 4 articles (B), the 1031 patients with IBD with GG vs AA rs3745635 genotype and the 1400 controls from 4 articles (C), and the 3309 patients with IBD with A vs G rs3745635 genotype and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotypes of rs3745635 and IBD. The odds ratios and 95% CIs of the 1712 patients with IBD with GA + AA vs GG rs3745635 genotype and the 1903 controls from 5 articles (A), the 1654 patients with IBD with GG + GA vs AA rs3745635 genotype and the 1843 controls from 4 articles (B), the 1031 patients with IBD with GG vs AA rs3745635 genotype and the 1400 controls from 4 articles (C), and the 3309 patients with IBD with A vs G rs3745635 genotype and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Figure 3.

Forest plots of meta-analysis of the genotypes of rs3894326 and IBD. The odds ratios and 95% CIs of 1712 patients with IBD with TA +AA vs TT genotype of the rs3894326 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TA vs AA genotype of the rs3894326 gene and the 1843 controls from 4 articles (B), the 1375 cases of IBD with TT vs AA genotype of the rs3894326 gene and the 1522 controls from 4 articles (C), and the 3309 patients with IBD with A vs T genotype of the rs3894326 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotypes of rs3894326 and IBD. The odds ratios and 95% CIs of 1712 patients with IBD with TA +AA vs TT genotype of the rs3894326 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TA vs AA genotype of the rs3894326 gene and the 1843 controls from 4 articles (B), the 1375 cases of IBD with TT vs AA genotype of the rs3894326 gene and the 1522 controls from 4 articles (C), and the 3309 patients with IBD with A vs T genotype of the rs3894326 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Figure 4.

Forest plots of meta-analysis of the genotype of the rs28362459 gene and IBD. The odds ratios and 95% CIs of the 1712 cases of IBD with TG + GG vs TT genotype of the rs28362459 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TG vs GG genotype of the rs28362459 gene and the 1843 controls from 4 articles (B), the 1046 patients with IBD with TT vs GG genotype of the rs28362459 gene and the 1157 controls from 4 articles (C), and the 3309 patients with IBD with G vs T genotype of the rs28362459 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.
Forest plots of meta-analysis of the genotype of the rs28362459 gene and IBD. The odds ratios and 95% CIs of the 1712 cases of IBD with TG + GG vs TT genotype of the rs28362459 gene and the 1903 controls from 5 articles (A), the 1654 patients with IBD with TT + TG vs GG genotype of the rs28362459 gene and the 1843 controls from 4 articles (B), the 1046 patients with IBD with TT vs GG genotype of the rs28362459 gene and the 1157 controls from 4 articles (C), and the 3309 patients with IBD with G vs T genotype of the rs28362459 gene and the 3684 controls from 4 articles (D) were analyzed by the M–H fixed-effect model. CI, confidence interval; IBD, inflammatory bowel disease; M–H, Mantel–Haenszel.

Meta-analysis of the association between FUT3 and IBD

Gene Genetic model Heterogeneity Consolidated results Egger test
χ2 P I2 (%) OR (95% CI) Z P t P
rs3745635 GG + GA vs AA 0.64 0.89 0 1.93 (1.23–3.05) 2.84 0.004 1.65 0.242
rs3745635 GA + AA vs GG 5.61 0.23 29 0.84 (0.72–0.97) 2.36 0.02 0.87 0.447
rs3745635 GG vs AA 2.45 0.48 0 2.38 (1.52–3.74) 3.76 0.000 0.15 0.897
rs3745635 A vs G 2.09 0.55 0 0.84 (0.73–0.96) 2.60 0.009 3.55 0.071
rs3894326 TA + AA vs TT 1.79 0.77 0 1.03 (0.87–1.23) 0.39 0.70 0.01 0.990
rs3894326 TT + TA vs AA 1.17 0.76 0 1.19 (0.56–2.51) 0.46 0.65 1.31 0.321
rs3894326 TT vs AA 1.24 0.74 0 1.19 (0.56–2.51) 0.45 0.65 1.32 0.317
rs3894326 A vs T 1.96 0.58 0 1.02 (0.86–1.20) 0.22 0.83 0.69 0.563
rs28362459 TG + GG vs TT 2.25 0.69 0 0.98 (0.85–1.12) 0.35 0.73 0.68 0.546
rs28362459 TT + TG vs GG 0.10 0.99 0 1.20 (0.90–1.61) 1.25 0.21 1.00 0.424
rs28362459 TT vs GG 0.26 0.97 0 1.21 (0.90–1.62) 1.25 0.21 0.37 0.746
rs28362459 G vs T 1.67 0.64 0 0.96 (0.86–1.07) 0.78 0.44 0.34 0.764

Basic characteristics of the included manuscripts

Article Nation Disease IBD Controls Gene
Age (years) M:F n Age (years) M:F n
Hu et al., 2014 [26] China CD 36.24 ± 14.52 121:152 273 36.76 ± 15.62 223:256 479 rs3745635, rs3894326, rs28362459
Xu et al., 2014 [27] China UC 42.25 ± 13.28 130:103 233 40.96 ± 15.42 157:135 292 rs3745635, rs3894326, rs28362459
Guo et al., 2015 [28] China UC 41.56 ± 14.45 224:165 389 41.24 ± 16.01 263:229 492 rs3745635, rs3894326, rs28362459
China CD 39.49 ± 16.51 153:121 274
Hu et al., 2016 [29] China UC 40.23 ± 15.32 201:284 485 41.09 ± 17.11 261:319 580 rs3745635, rs3894326, rs28362459
Chen et al., 2018 [30] China UC 36–59 31:27 58 34–60 34:26 60 rs3745635, rs3894326, rs28362459

Quality evaluation of the included articles with NOS

Article Item 1 Item 2 Item 3 Item 4 Item 5 Item 6 Item 7 Item 8 Score
Hu et al., 2014 [26] Yes Unclear Yes Yes Age, gender Yes Yes Yes 8
Xu et al., 2014 [27] Yes Unclear Yes Yes Age, gender Yes Yes Yes 8
Guo et al., 2015 [28] Yes Unclear Yes Yes Age, gender Yes Yes Yes 8
Hu et al., 2016 [29] Yes Unclear Yes Yes Age, gender Yes Yes Yes 8
Chen et al., 2018 [30] Yes Unclear Yes Yes Age, gender Yes Yes Yes 8
eISSN:
1875-855X
Langue:
Anglais
Périodicité:
6 fois par an
Sujets de la revue:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine
RSS Feed de la revue