<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Stereochemistry plays an important role in drug design because the enantiomers of a drug frequently vary in their biological action and pharmacokinetic profiles. Racemates of a drug with either an inactive or an unsafe enantiomer can lead to detrimental effects. The manufacturing industry may still produce racemates, but such decisions must pass through rigorous analyses of the pharmacological and pharmacokinetic characteristics of the particular enantiomer related to the racemates. The pharmacokinetics of antidepressants or antidepressive agents is stereoselective and predominantly favors one enantiomer. The use of pure enantiomers offers (i) better specificity than the racemates in terms of certain pharmacological actions, (ii) enhanced clinical indications, and (iii) optimized pharmacokinetics. Therefore, controlling the stereoselectivity in the pharmacokinetics of antidepressive drugs is of critical importance in dealing with depression and psychiatric conditions. The objective of this review is to highlight the importance of the stereochemistry of antidepressants in the context of the design and development of new chirally pure pharmaceuticals, the potential complications caused by using racemates, and the benefits of using pure enantiomers.</p>
</abstract>

Stereochemistry plays an important role in drug design because the enantiomers of a drug frequently vary in their biological action and pharmacokinetic profiles. Racemates of a drug with either an inactive or an unsafe enantiomer can lead to detrimental effects. The manufacturing industry may still produce racemates, but such decisions must pass through rigorous analyses of the pharmacological and pharmacokinetic characteristics of the particular enantiomer related to the racemates. The pharmacokinetics of antidepressants or antidepressive agents is stereoselective and predominantly favors one enantiomer. The use of pure enantiomers offers (i) better specificity than the racemates in terms of certain pharmacological actions, (ii) enhanced clinical indications, and (iii) optimized pharmacokinetics. Therefore, controlling the stereoselectivity in the pharmacokinetics of antidepressive drugs is of critical importance in dealing with depression and psychiatric conditions. The objective of this review is to highlight the importance of the stereochemistry of antidepressants in the context of the design and development of new chirally pure pharmaceuticals, the potential complications caused by using racemates, and the benefits of using pure enantiomers.

Chirality of antidepressive drugs: an overview of stereoselectivity

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Chirality of antidepressive drugs: an overview of stereoselectivity"}

Stereochemistry plays an important role in drug design because the enantiomers of a drug frequently vary in their biological action and pharmacokinetic...

Chirality of antidepressive drugs: an overview of stereoselectivity

Article Category: Review

Publié en ligne: 29 avr. 2022

Pages: 55 - 69

DOI: https://doi.org/10.2478/abm-2022-0008

Mots clés
antidepressive agents, chiral, depression, pharmacokinetics, stereoselective

© 2022 Vinod Kumar Vashistha et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Chirality of antidepressive drugs: an overview of stereoselectivity

Article Category: Review

Publié en ligne: 29 avr. 2022

Pages: 55 - 69

DOI: https://doi.org/10.2478/abm-2022-0008

Mots clésantidepressive agents, chiral, depression, pharmacokinetics, stereoselective

© 2022 Vinod Kumar Vashistha et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Mots clés
antidepressive agents, chiral, depression, pharmacokinetics, stereoselective