<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Our Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this <italic>in vivo</italic> study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC®) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC® was administered immediately after contamination. The results showed that decontamination with MCC® could achieve therapeutic efficacy corresponding to 3 x LD<sub>50</sub> of percutaneous sarin and call for further research.</p></abstract>

Our Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this in vivo study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC®) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC® was administered immediately after contamination. The results showed that decontamination with MCC® could achieve therapeutic efficacy corresponding to 3 x LD50 of percutaneous sarin and call for further research.

Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined <italic>In Vivo</italic>

Institute of Researches and Development of Defense Systems, Zagreb, Croatia

Ruđer Bošković Institute, Zagreb, Croatia

Archives of Industrial Hygiene and Toxicology

Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined 

Our Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against...

Skin Decontamination with Mineral Cationic Carrier Against Sarin Determined In Vivo

Publié en ligne: 06 juil. 2009

Pages: 173 - 177

DOI: https://doi.org/10.2478/10004-1254-60-2009-1893

Mots clés
bioactive potential, MCC®, nerve agent, NOD mice, sorption powder, toxicity

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