<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-3). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance.Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41±3.66) μg L-1, C group (5.60±0.86) μg L-1, p&lt;0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59±81.27) μmol L-1, C group (105.21±49.62) μmol L-1, p&lt;0.001] and antioxidative enzyme activity reduced for glucoso-6-phosphate-dehydrogenase [Al group (5.05±1.70) IU g-1 Hb, C group (12.53±4.12) IU g-1 Hb, p&lt;0.001], glutathione reductase [Al group (1.41±0.56) IU g-1 Hb, C group (1.89±0.57) IU g-1 Hb, p&lt;0.001], glutathione peroxidase [Al group (12.37±5.76) IU g-1 Hb, C group (15.54±4.85) IU g-1 Hb, p&lt;0.001], catalase [Al group (116.76±26.60) IU g-1 Hb, C group (158.81±71.85) IU g-1 Hb, p&lt;0.001] and superoxide dismutase [Al group (1175.8±149.9) IU mg-1 Hb, C group (1377.9±207.5) IU mg-1 Hb, p&lt;0.001].</abstract>

Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-3). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance.Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41±3.66) μg L-1, C group (5.60±0.86) μg L-1, p<0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59±81.27) μmol L-1, C group (105.21±49.62) μmol L-1, p<0.001] and antioxidative enzyme activity reduced for glucoso-6-phosphate-dehydrogenase [Al group (5.05±1.70) IU g-1 Hb, C group (12.53±4.12) IU g-1 Hb, p<0.001], glutathione reductase [Al group (1.41±0.56) IU g-1 Hb, C group (1.89±0.57) IU g-1 Hb, p<0.001], glutathione peroxidase [Al group (12.37±5.76) IU g-1 Hb, C group (15.54±4.85) IU g-1 Hb, p<0.001], catalase [Al group (116.76±26.60) IU g-1 Hb, C group (158.81±71.85) IU g-1 Hb, p<0.001] and superoxide dismutase [Al group (1175.8±149.9) IU mg-1 Hb, C group (1377.9±207.5) IU mg-1 Hb, p<0.001].

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Institute of Occupational Health "Dr Dragomir Karajović", Beograd, Serbia

Institute of Immunology "Torlak", Beograd, Serbia

Institute of Chemistry, Technology and Metallurgy, Beograd, Serbia

Archives of Industrial Hygiene and Toxicology

Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and...

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Publié en ligne: 23 juin 2008

Pages: 81 - 87

DOI: https://doi.org/10.2478/10004-1254-59-2008-1853

Mots clés
glukozo-6-fosfatdehidrogenaza, glutationperoksidaza, glutationreduktaza, katalaza, malondialdehid, profesionalna izloženost, superoksiddismutaza

This content is open access.

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Publié en ligne: 23 juin 2008

Pages: 81 - 87

DOI: https://doi.org/10.2478/10004-1254-59-2008-1853

Mots clésglukozo-6-fosfatdehidrogenaza, glutationperoksidaza, glutationreduktaza, katalaza, malondialdehid, profesionalna izloženost, superoksiddismutaza

This content is open access.

Mots clés
glukozo-6-fosfatdehidrogenaza, glutationperoksidaza, glutationreduktaza, katalaza, malondialdehid, profesionalna izloženost, superoksiddismutaza