<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The microbiome influences host processes including nutritional availability, development, immunity, and behavioral responses. <italic>Caenorhabditis elegans</italic> is a powerful model to study molecular mechanisms of host–microbial interactions. Recent efforts have been made to profile the natural microbiome of <italic>C. elegans</italic>, laying a foundation for mechanistic studies of host–microbiome interactions in this genetically tractable model system. Studies using single-species microbes, multi-microbial systems, and humanized worm–microbiome interaction studies reveal metabolic and microbial–microbial interactions relevant in higher organisms. This article discusses recent developments in modeling the effects of host–microbiome interactions in <italic>C. elegans</italic>.</p>
</abstract>

The microbiome influences host processes including nutritional availability, development, immunity, and behavioral responses. Caenorhabditis elegans is a powerful model to study molecular mechanisms of host–microbial interactions. Recent efforts have been made to profile the natural microbiome of C. elegans, laying a foundation for mechanistic studies of host–microbiome interactions in this genetically tractable model system. Studies using single-species microbes, multi-microbial systems, and humanized worm–microbiome interaction studies reveal metabolic and microbial–microbial interactions relevant in higher organisms. This article discusses recent developments in modeling the effects of host–microbiome interactions in C. elegans.

Modeling Host-Microbiome Interactions in <italic>Caenorhabditis elegans</italic>


Journal of Nematology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Modeling Host-Microbiome Interactions in 


The microbiome influences host processes including nutritional availability, development, immunity, and behavioral responses. Caenorhabditis elegans is a...

Modeling Host-Microbiome Interactions in Caenorhabditis elegans

Publié en ligne: 26 sept. 2018

Pages: 348 - 356

Reçu: 01 mars 2017

DOI: https://doi.org/10.21307/jofnem-2017-082

Mots clés
host, microbiome interactions, humanized worms, microbiome

© 2017 TEKLU K. GERBABA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Modeling Host-Microbiome Interactions in Caenorhabditis elegans

Publié en ligne: 26 sept. 2018

Pages: 348 - 356

Reçu: 01 mars 2017

DOI: https://doi.org/10.21307/jofnem-2017-082

Mots cléshost, microbiome interactions, humanized worms, microbiome

© 2017 TEKLU K. GERBABA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
host, microbiome interactions, humanized worms, microbiome