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Anonimous: The renaissance of rational polytherapy: the new generation of antiepileptic medications. Neurology, 1995, 45: 35–38.Anonimous: The renaissance of rational polytherapy: the new generation of antiepileptic medications. Neurology, 1995, 45: 35–38.Search in Google Scholar
Barcs G., Walker E.B., Elger C.E., Scaramelli A., Stefan H., Sturm T. et al.: Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia, 2000, 4: 1597–1607.BarcsG.WalkerE.B.ElgerC.E.ScaramelliA.StefanH.SturmT.: Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia, 2000, 4: 1597–1607.10.1111/j.1499-1654.2000.001597.xSearch in Google Scholar
Barker-Haliski M., Sills G.J., White H.S.: What are the arguments for and against rational therapy for epilepsy? Adv. Exp. Med. Biol., 2014, 813: 295–308. Available at: https://link.springer.com/chapter/10.1007%2F978-94-017-8914-1_24.Barker-HaliskiM.SillsG.J.WhiteH.S.: What are the arguments for and against rational therapy for epilepsy?Adv. Exp. Med. Biol., 2014, 813: 295–308. Available at: https://link.springer.com/chapter/10.1007%2F978-94-017-8914-1_24.10.1007/978-94-017-8914-1_24Search in Google Scholar
Baulac M., Brodie M.J., Patten A., Segieth J., Giorgi L.: Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol., 2012, 11: 579–588.BaulacM.BrodieM.J.PattenA.SegiethJ.GiorgiL.: Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. Lancet Neurol., 2012, 11: 579–588.10.1016/S1474-4422(12)70105-9Search in Google Scholar
Beghi E., Tonini C., Ben-Menachem E., Chadwick D.W., Nikanorova M.: Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial. Epilepsy Res., 2003, 57: 1–13.BeghiE.ToniniC.Ben-MenachemE.ChadwickD.W.NikanorovaM.: Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial. Epilepsy Res., 2003, 57: 1–13.10.1016/j.eplepsyres.2003.09.00714706729Search in Google Scholar
Ben-Menachem E.: Medical management of refractory epilepsy-practical treatment with novel antiepileptic drugs. Epilepsia, 2014, 55: 3–8.Ben-MenachemE.: Medical management of refractory epilepsy-practical treatment with novel antiepileptic drugs. Epilepsia, 2014, 55: 3–8.10.1111/epi.1249424400690Search in Google Scholar
Besag F.M., Berry D.J., Pool F., Newberg J.E., Subel B.: Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction? Epilepsia, 1998, 39: 183–187.BesagF.M.BerryD.J.PoolF.NewbergJ.E.SubelB.: Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction?Epilepsia, 1998, 39: 183–187.10.1111/j.1528-1157.1998.tb01356.x9577998Search in Google Scholar
Borowicz K.K., Swiader M., Luszczki J., Czuczwar S. J.: Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. Epilepsia, 2002, 43: 956–963. Available at: http://onlinelibrary.wiley.com/store/10.1046/j.1528-1157.2002.34301.x/asset/j.1528-1157.2002.34301.x.pdf?v=1&t=jeirjnx7&s=1bbfc6383dd021f64099062233d819038b8eecbd.BorowiczK.K.SwiaderM.LuszczkiJ.CzuczwarS. J.: Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. Epilepsia, 2002, 43: 956–963. Available at: http://onlinelibrary.wiley.com/store/10.1046/j.1528-1157.2002.34301.x/asset/j.1528-1157.2002.34301.x.pdf?v=1&t=jeirjnx7&s=1bbfc6383dd021f64099062233d819038b8eecbd.10.1046/j.1528-1157.2002.34301.x12199720Search in Google Scholar
Brigo F., Ausserer H., Tezzon F., Nardone R.: When one plus one makes three: the quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy. Epilepsy Behav., 2013, 27: 439–442.BrigoF.AussererH.TezzonF.NardoneR.: When one plus one makes three: the quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy. Epilepsy Behav., 2013, 27: 439–442.10.1016/j.yebeh.2013.03.01023591263Search in Google Scholar
Brodie M.J., French J.A., McDonald S.A., Lee W.-J., Adams B., Scott A., Nohria V., DeRossett S.: Adjunctive use of ezogabine/ retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: Evaluation of efficacy and tolerability. Epilepsy Res., 2014, 108: 989–994. Available at: https://www.sciencedirect.com/science/article/pii/S0920121114000825?via%3Dihub.BrodieM.J.FrenchJ.A.McDonaldS.A.LeeW.-J.AdamsB.ScottA.NohriaV.DeRossettS.: Adjunctive use of ezogabine/ retigabine with either traditional sodium channel blocking antiepileptic drugs (AEDs) or AEDs with other mechanisms of action: Evaluation of efficacy and tolerability. Epilepsy Res., 2014, 108: 989–994. Available at: https://www.sciencedirect.com/science/article/pii/S0920121114000825?via%3Dihub.10.1016/j.eplepsyres.2014.03.00824726452Search in Google Scholar
Brodie M.J.: Road to refractory epilepsy: the Glasgow story. Epilepsia, 2013, 54: 5–8.BrodieM.J.: Road to refractory epilepsy: the Glasgow story. Epilepsia, 2013, 54: 5–8.10.1111/epi.1217523646962Search in Google Scholar
Brodie M.J.: Pharmacological treatment of drug-resistant epilepsy in adults: a practical guide. Curr. Neurol. Neurosci. Rep., 2016, 16: 82. doi: 10.1007/s11910-016-0678-xBrodieM.J.: Pharmacological treatment of drug-resistant epilepsy in adults: a practical guide. Curr. Neurol. Neurosci. Rep., 2016, 16: 82. doi: 10.1007/s11910-016-0678-xOpen DOISearch in Google Scholar
Brodie M.J., Munford J.P.: Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res., 1999, 34: 199–205.BrodieM.J.MunfordJ.P.: Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res., 1999, 34: 199–205.10.1016/S0920-1211(98)00110-7Search in Google Scholar
Brodie M.J., Yuen A.W.: Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res., 1997, 26: 423–432.BrodieM.J.YuenA.W.: Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res., 1997, 26: 423–432.10.1016/S0920-1211(96)01007-8Search in Google Scholar
Brodie M.J., Bamagous G.K.P.: Improved outcomes in newly diagnosed epilepsy. Epilepsia, 2009, 50: 411–412.BrodieM.J.BamagousG.K.P.: Improved outcomes in newly diagnosed epilepsy. Epilepsia, 2009, 50: 411–412.Search in Google Scholar
Cereghino J.J., Brock J.T., Van Meter J.C., Penry J.K., Smith L.D., White B.G.: The efficacy of carbamazepine combinations in epilepsy. Clin. Pharmacol. Ther., 1975, 18: 733–741.CereghinoJ.J.BrockJ.T.Van MeterJ.C.PenryJ.K.SmithL.D.WhiteB.G.: The efficacy of carbamazepine combinations in epilepsy. Clin. Pharmacol. Ther., 1975, 18: 733–741.10.1002/cpt1975186733Search in Google Scholar
Chez M.G., Bourgeois B.F., Pipenger C.E., Knowles W.D.: Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. Clin. Neuropharmacol., 1994, 17: 32–37.ChezM.G.BourgeoisB.F.PipengerC.E.KnowlesW.D.: Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. Clin. Neuropharmacol., 1994, 17: 32–37.10.1097/00002826-199402000-00003Search in Google Scholar
Chung S., Ben-Menachem E., Sperling M.R., Rosenfeld W., Foutain N., Benbadis S.: Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials. CNS Drugs, 2010, 24: 1041–1054. doi: 10.2165/11586830-000000000-00000.ChungS.Ben-MenachemE.SperlingM.R.RosenfeldW.FoutainN.BenbadisS.: Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trials. CNS Drugs, 2010, 24: 1041–1054. doi: 10.2165/11586830-000000000-00000.Open DOISearch in Google Scholar
Cuadrado A., Chevas D.L., Valdizan E.M., Armijo J.A.: Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. Eur. J. Pharmacol., 2002, 453: 43–52.CuadradoA.ChevasD.L.ValdizanE.M.ArmijoJ.A.: Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. Eur. J. Pharmacol., 2002, 453: 43–52.10.1016/S0014-2999(02)02341-5Search in Google Scholar
Deckers C.L., Czuczwar S.J., Hekster Y.A., Keyser A., Kubova H., Meinardi H.: Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia, 2000, 4: 1364–1374.DeckersC.L.CzuczwarS.J.HeksterY.A.KeyserA.KubovaH.MeinardiH.: Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia, 2000, 4: 1364–1374.10.1111/j.1528-1157.2000.tb00111.x11077449Search in Google Scholar
Deckers C.L.P., Hekster T.A., Keyser A., van Lier H.J.J., Meinardi H., Renier W.O.: Monotherapy versus polytherapy for epilepsy: A multicenter double-blind randomized study. Epilepsia, 2001, 42: 1387–1394.DeckersC.L.P.HeksterT.A.KeyserA.van LierH.J.J.MeinardiH.RenierW.O.: Monotherapy versus polytherapy for epilepsy: A multicenter double-blind randomized study. Epilepsia, 2001, 42: 1387–1394.10.1046/j.1528-1157.2001.30800.x11879339Search in Google Scholar
Ferrendelli J.A.: Relating pharmacology to clinical practice: the pharmacologic basis of rational polypharmacy. Neurology, 1995, 45: 12–16.FerrendelliJ.A.: Relating pharmacology to clinical practice: the pharmacologic basis of rational polypharmacy. Neurology, 1995, 45: 12–16.Search in Google Scholar
Flores L., Kemp S., Colbeck K., Moran N., Quirk J., Ramkolea P. et al: Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: A multicentre study in epilepsy clinics in the United Kingdom (UK). Seizure, 2012, 21: 512–517. http://www.ncbi.nlm.nih.gov/pubmed/7898740.FloresL.KempS.ColbeckK.MoranN.QuirkJ.RamkoleaP.: Clinical experience with oral lacosamide as adjunctive therapy in adult patients with uncontrolled epilepsy: A multicentre study in epilepsy clinics in the United Kingdom (UK). Seizure, 2012, 21: 512–517. http://www.ncbi.nlm.nih.gov/pubmed/7898740.10.1016/j.seizure.2012.05.005Search in Google Scholar
French J.A., Faught E.: Rational polytherapy. Epilepsia, 2009, 50: 63–68. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19702736.FrenchJ.A.FaughtE.: Rational polytherapy. Epilepsia, 2009, 50: 63–68. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19702736.10.1111/j.1528-1167.2009.02238.xSearch in Google Scholar
Halasz P., Cramer J.A., Hodoba D., Czionkowska A., Guekht A., Maia J.: Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy. Epilepsia, 2010, 51: 1963–1969.HalaszP.CramerJ.A.HodobaD.CzionkowskaA.GuekhtA.MaiaJ.: Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy. Epilepsia, 2010, 51: 1963–1969.10.1111/j.1528-1167.2010.02660.xSearch in Google Scholar
Jonker D.M., Voskuyl R.A., Danhof M.: Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments? Epilepsia, 2007, 48: 412–434.JonkerD.M.VoskuylR.A.DanhofM.: Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?Epilepsia, 2007, 48: 412–434.10.1111/j.1528-1167.2006.00952.xSearch in Google Scholar
Kwan P., Brodie M.J.: Early identification of refractory epilepsy. N. Engl. J. Med., 2000a, 342: 314–319.KwanP.BrodieM.J.: Early identification of refractory epilepsy. N. Engl. J. Med., 2000a, 342: 314–319.10.1056/NEJM200002033420503Search in Google Scholar
Kwan P., Brodie M.J.: Epilepsy after the first drug fails: substitution or add-on? Seizure, 2000b, 9: 464–468.KwanP.BrodieM.J.: Epilepsy after the first drug fails: substitution or add-on?Seizure, 2000b, 9: 464–468.10.1053/seiz.2000.0442Search in Google Scholar
Leach J.P., Brodie M.J.: Synergism with GABAergic drugs in refractory epilepsy. Lancet, 1994, 343: 1650.LeachJ.P.BrodieM.J.: Synergism with GABAergic drugs in refractory epilepsy. Lancet, 1994, 343: 1650.10.1016/S0140-6736(94)93110-0Search in Google Scholar
Luszczki J.J., Czuczwar P., Cioczek-Czuczwar A., Wojcik-Cwikla J., Ratnaraj N.: Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Epilepsia, 2003, 44: 1003–1013.LuszczkiJ.J.CzuczwarP.Cioczek-CzuczwarA.Wojcik-CwiklaJ.RatnarajN.: Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Epilepsia, 2003, 44: 1003–1013.10.1046/j.1528-1157.2003.10003.x12887431Search in Google Scholar
Luszczki J.J., Czuczwar S.J.: Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis. Eur. Neuropsychopharmacol., 2005, 15: 133–142.LuszczkiJ.J.CzuczwarS.J.: Interaction between lamotrigine and felbamate in the maximal electroshock-induced seizures in mice: an isobolographic analysis. Eur. Neuropsychopharmacol., 2005, 15: 133–142.10.1016/j.euroneuro.2004.06.00215695057Search in Google Scholar
Margolis J.M., Chu B-C., Wang Z.J., Copher R., Cavazos J.E.: Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action. JAMA Neurol., 2014, 71: 985–993. Available at: https://jamanetwork.com/journals/jamaneurology/articlepdf/1877433/noi140030.pdf.MargolisJ.M.ChuB-C.WangZ.J.CopherR.CavazosJ.E.: Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action. JAMA Neurol., 2014, 71: 985–993. Available at: https://jamanetwork.com/journals/jamaneurology/articlepdf/1877433/noi140030.pdf.10.1001/jamaneurol.2014.80824911669Search in Google Scholar
Masuda Y., Utsui Y., Shiraishi T., Karasawa T., Yoshida K., Shimizu M.: Evidence for a synergistic interaction between phenytoin and phenobarbital in experimental animals. J.Pharmacol. Exp. Ther., 1981, 217: 805–811.MasudaY.UtsuiY.ShiraishiT.KarasawaT.YoshidaK.ShimizuM.: Evidence for a synergistic interaction between phenytoin and phenobarbital in experimental animals. J.Pharmacol. Exp. Ther., 1981, 217: 805–811.Search in Google Scholar
Mattson R.H., Cramer J.A., Collins J.F.: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N. Engl. J. Med., 1992, 327: 765–771.MattsonR.H.CramerJ.A.CollinsJ.F.: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group. N. Engl. J. Med., 1992, 327: 765–771.10.1056/NEJM199209103271104Search in Google Scholar
Mawer G.E., Pleuvry B.J.: Interactions involving new antiepileptic drugs. Pharmacol. Ther., 1995, 68: 209–231. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8719968.MawerG.E.PleuvryB.J.: Interactions involving new antiepileptic drugs. Pharmacol. Ther., 1995, 68: 209–231. Available at: http://www.ncbi.nlm.nih.gov/pubmed/8719968.10.1016/0163-7258(95)02006-3Search in Google Scholar
Moeller J.J., Rahey S.R., Sadler R.M.: Lamotrigine-valproic acid combination therapy for medically refractory epilepsy. Epilepsia, 2009, 50: 475–479.MoellerJ.J.RaheyS.R.SadlerR.M.: Lamotrigine-valproic acid combination therapy for medically refractory epilepsy. Epilepsia, 2009, 50: 475–479.10.1111/j.1528-1167.2008.01866.xSearch in Google Scholar
Perucca E.: Clinically relevant drug interactions with antiepileptic drugs. Br. J. Clin. Pharmacol., 2006, 61: 246–255.PeruccaE.: Clinically relevant drug interactions with antiepileptic drugs. Br. J. Clin. Pharmacol., 2006, 61: 246–255.10.1111/j.1365-2125.2005.02529.xSearch in Google Scholar
Pisani F., Oteri G., Russo M.F., Di Perri R., Perruca E., Richens A.: The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. Epilepsia, 1999, 40: 1141–1146.PisaniF.OteriG.RussoM.F.Di PerriR.PerrucaE.RichensA.: The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. Epilepsia, 1999, 40: 1141–1146.10.1111/j.1528-1157.1999.tb00832.xSearch in Google Scholar
Reynolds E.H., Chadwick D., Galbraith A.W.: One drug (phenytoin) in the treatment of epilepsy. The Lancet, 1976, 307: 923–926.ReynoldsE.H.ChadwickD.GalbraithA.W.: One drug (phenytoin) in the treatment of epilepsy. The Lancet, 1976, 307: 923–926.10.1016/S0140-6736(76)92709-4Search in Google Scholar
Reynolds E.H., Shorvon S.D.: Monotherapy or polytherapy for epilepsy? Epilepsia, 1981, 22: 1–10.ReynoldsE.H.ShorvonS.D.: Monotherapy or polytherapy for epilepsy?Epilepsia, 1981, 22: 1–10.10.1111/j.1528-1157.1981.tb04327.x6781884Search in Google Scholar
Rowan A.J., de Beer-Pawlikowski N., van der Geest P., Meinardi H.: Valproate-ethosuximide combination therapy for refractory absence seizures. Arch. Neurol., 1983, 40: 797–802.RowanA.J.de Beer-PawlikowskiN.van der GeestP.MeinardiH.: Valproate-ethosuximide combination therapy for refractory absence seizures. Arch. Neurol., 1983, 40: 797–802.10.1001/archneur.1983.040501200470066416232Search in Google Scholar
Russmann V., Salvamoser J.D., Rettenbeck M.L., Komori T., Potschka H.: Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy. Epilepsia, 2016, 57: 638–647.RussmannV.SalvamoserJ.D.RettenbeckM.L.KomoriT.PotschkaH.: Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy. Epilepsia, 2016, 57: 638–647.10.1111/epi.1332826854031Search in Google Scholar
Sake J-K., Herbert D., Isojarvi J., Doty P., De Backer M., Davies K. et al: A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitamt antiepileptic drugs. CNS Drugs, 2010, 24: 1055–1068.SakeJ-K.HerbertD.IsojarviJ.DotyP.De BackerM.DaviesK.: A pooled analysis of lacosamide clinical trial data grouped by mechanism of action of concomitamt antiepileptic drugs. CNS Drugs, 2010, 24: 1055–1068.10.2165/11587550-000000000-0000021090839Search in Google Scholar
Shandra A., Shandra P., Kaschenko O., Matagne A., Stöhr T.: Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice. Epilepsia, 2013, 54: 1167–1175.ShandraA.ShandraP.KaschenkoO.MatagneA.StöhrT.: Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice. Epilepsia, 2013, 54: 1167–1175.10.1111/epi.12237Search in Google Scholar
Shank R.P., Gardocki J.F., Vaught J.L., Schupski J.J., Raffa R.B.: Topiramate: preclinical evaluation of structurally novel anticonvulsant. Epilepsia, 1994, 35: 450–460.ShankR.P.GardockiJ.F.VaughtJ.L.SchupskiJ.J.RaffaR.B.: Topiramate: preclinical evaluation of structurally novel anticonvulsant. Epilepsia, 1994, 35: 450–460.10.1111/j.1528-1157.1994.tb02459.xSearch in Google Scholar
St Louis E.K.: Truly “rational” polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. Curr. Neuropharmacol., 2009, 7: 96–105.St LouisE.K.: Truly “rational” polytherapy: maximizing efficacy and minimizing drug interactions, drug load, and adverse effects. Curr. Neuropharmacol., 2009, 7: 96–105.10.2174/157015909788848929Search in Google Scholar
Stephen L.J., Brodie M.J.: Seizure freedom with more than one antiepileptic drug. Seizure, 2002, 11: 349–351.StephenL.J.BrodieM.J.: Seizure freedom with more than one antiepileptic drug. Seizure, 2002, 11: 349–351.10.1053/seiz.2002.0711Search in Google Scholar
Stephen L.J., Sills, G.J., Brodie M.J.: Lamotrigine and topiramate may be a useful combination. Lancet, 1998, 351: 958–959.StephenL.J.Sills,G.J.BrodieM.J.: Lamotrigine and topiramate may be a useful combination. Lancet, 1998, 351: 958–959.10.1016/S0140-6736(05)60613-7Search in Google Scholar
Walker J.E., Koon R.: Carbamazepine versus valproate versus combine therapy for refractory partial complex seizures with secondary generalization. Epilepsia, 1988, 29: 693 (abst).WalkerJ.E.KoonR.: Carbamazepine versus valproate versus combine therapy for refractory partial complex seizures with secondary generalization. Epilepsia, 1988, 29: 693 (abst).Search in Google Scholar
