Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid

Coves-Orts FJ., Borrás-Blasco J., Navarro-Ruiz A., Murcia-López A., Palacios-Ortega F.:Acute seizures due to a probable interaction between valproic acid and meropenem. Ann. Phar-macother., 2005, 39: 533–537.10.1345/aph.1E358Search in Google Scholar

Fudio S., Carcas A., Piñana E., Ortega R.:Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. J. Clin. Pharm. Ther., 2006, 31: 393–396.10.1111/j.1365-2710.2006.00743.xSearch in Google Scholar

Hellwig T.R., Onisk M.L., Chapman B.A .:Potential interaction between valproic acid and doripenem. Curr. Drug. Saf., 2011, 6: 54–58.10.2174/157488611794480007Search in Google Scholar

Johannessen C.U., Johannessen S.I.:Valproate: past, present, and future. CNS Drug. Rev., 2003, 9: 199–216.10.1111/j.1527-3458.2003.tb00249.xSearch in Google Scholar

Llinares Tello F., Bosacoma Ros N., Hernandes Prats C., Cli-ment Grana E., Selva Otaolaurruchi J.:Ordovás Baines JP Interaction farmacocinética entre ácido valproico y antibióticos carbapenémicos: descripción de tres casos. Farmacia Hospitalaria, 2003, 27: 258–263.Search in Google Scholar

Lunde J.L., Nelson R.E., Storandt H.F.:Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. Pharmacotherapy, 2007, 278: 1202–1205.10.1592/phco.27.8.1202Search in Google Scholar

Mancl E.E., Gidal B.E.:The effect of carbapenem antibiotics on plasma concentrations of valproic acid. Ann. Pharmacoth-er., 2009, 43: 2082–2087.10.1345/aph.1M296Search in Google Scholar

Omoda K., Murakami T., Yumoto R., Nagai J., Maeda Y., Kiri-bayashi Y., Takano M.:Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human. J. Pharm. Sci., 2005, 8: 1685–1693.10.1002/jps.20338Search in Google Scholar

Park M.K., Lim K.S., Kim T.E., Han H.K., Yi S.J., Shin K.H. et al.:Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. Ther. Drug. Monit., 2012, 34: 599–603.10.1097/FTD.0b013e318260f7b3Search in Google Scholar

Perea Falomir M., Roura Poch P., Higueruelo Demason S., Garcia Gil V.K.:Descripción de un caso de interacción farma-cocinética entre ácido valproico e imipenem. Farmacia Hospitalaria, 2006, 30: 316–317.10.1016/S1130-6343(06)73999-XSearch in Google Scholar

Taha F.A., Hammond D.N., Sheth R.D.:Seizures from valpro-ate-carbapenem interaction. Pediatr. Neurol., 2013, 49: 279–281.10.1016/j.pediatrneurol.2013.03.02223932807Search in Google Scholar

Vélez Díaz-Pallarés M., Delgado Silveira E., Alvarez Díaz A.M., Pérez Menéndez-Conde C., Vicente Oliveros N., Ber-mejo Vicedo T.:Analysis of the valproic acid-meropenem interaction in hospitalised patients. Neurologia, 2012, 27: 34–38.10.1016/j.nrleng.2011.03.006Search in Google Scholar

Zhanel G.G., Wiebe R., Dilay L., Thomson K., Rubinstein E., Hoban D.J. et al.:Comparative review of the carbapenems. Drugs, 2007, 67: 1027–1052.10.2165/00003495-200767070-0000617488146Search in Google Scholar