<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2016-0003_s_001"><h3>Background</h3><p>Epilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER).</p></sec><sec id="j_joepi-2016-0003_s_002"><h3>Aim</h3><p>With the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition.</p></sec><sec id="j_joepi-2016-0003_s_003"><h3>Material and Methods</h3><p>We present a case where PER was the last AED introduced in the treatment of a patient with EPC and individual seizures due to Rasmussen encephalitis before his seizure frequency could be reduced significantly.</p></sec><sec id="j_joepi-2016-0003_s_004"><h3>Results</h3><p>A 44 years old male patient, who had been on a combination therapy of at least 4 AEDs since the age of 24, was admitted to our hospital presenting with an EPC. After the introduction of PER in the therapy EPC stopped and he remained seizure free for more than a year. Two of his other AEDs could be tapered of.</p></sec><sec id="j_joepi-2016-0003_s_005"><h3>Conclusion</h3><p>PER might be especially effective in EPC.</p></sec></abstract>

BackgroundEpilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER).AimWith the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition.Material and MethodsWe present a case where PER was the last AED introduced in the treatment of a patient with EPC and individual seizures due to Rasmussen encephalitis before his seizure frequency could be reduced significantly.ResultsA 44 years old male patient, who had been on a combination therapy of at least 4 AEDs since the age of 24, was admitted to our hospital presenting with an EPC. After the introduction of PER in the therapy EPC stopped and he remained seizure free for more than a year. Two of his other AEDs could be tapered of.ConclusionPER might be especially effective in EPC.

Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel

Journal of Epileptology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

BackgroundEpilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously...

Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel

Publié en ligne: 31 mars 2016

Pages: 67 - 70

Reçu: 14 déc. 2015

Accepté: 18 mars 2016

DOI: https://doi.org/10.21307/joepi-2016-0003

Mots clés
perampanel, Epilepsia Partialis Continua, Rasmussen encephalitis

© 2016 Katja Göde et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel

Publié en ligne: 31 mars 2016

Pages: 67 - 70

Reçu: 14 déc. 2015

Accepté: 18 mars 2016

DOI: https://doi.org/10.21307/joepi-2016-0003

Mots clésperampanel, Epilepsia Partialis Continua, Rasmussen encephalitis

© 2016 Katja Göde et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
perampanel, Epilepsia Partialis Continua, Rasmussen encephalitis