The P1PK blood group system: revisited and resolved

1. Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:25–33. Hellberg Å Westman JS Thuresson B Olsson ML. P1PK: the blood group system that changed its name and expanded . Immunohematology 2013 ; 29 : 25 – 33 . 10.21307/immunohematology-2019-120 Search in Google Scholar

2. Veldhuisen B, van der Schoot CE, de Haas M. Blood group genotyping: from patient to high-throughput donor screening. Vox Sang 2009;97:198–206. Veldhuisen B van der Schoot CE de Haas M. Blood group genotyping: from patient to high-throughput donor screening . Vox Sang 2009 ; 97 : 198 – 206 . 10.1111/j.1423-0410.2009.01209.x Search in Google Scholar

3. Bezirgiannidou Z, Christoforidou A, Kontekaki E, et al. Hyperhemolytic syndrome complicating a delayed hemolytic transfusion reaction due to anti-P1 alloimmunization, in a pregnant woman with HbO-Arab/ß-thalassemia. Mediterr J Hematol Infect Dis 2016;8:e2016053. Bezirgiannidou Z Christoforidou A Kontekaki E , Hyperhemolytic syndrome complicating a delayed hemolytic transfusion reaction due to anti-P1 alloimmunization, in a pregnant woman with HbO-Arab/ß-thalassemia . Mediterr J Hematol Infect Dis 2016 ; 8 : e2016053 . 10.4084/mjhid.2016.053 Search in Google Scholar

4. Smith D, Aye T, Er LS, Nester T, Delaney M. Acute hemolytic transfusion reaction due to anti-P1: a case report and review of institutional experience. Transfus Med Hemother 2019;46:381–4. Smith D Aye T Er LS Nester T Delaney M. Acute hemolytic transfusion reaction due to anti-P1: a case report and review of institutional experience . Transfus Med Hemother 2019 ; 46 : 381 – 4 . 10.1159/000490897 Search in Google Scholar

5. Kaczmarek R, Duk M, Szymczak K, et al. Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens. Biochem Biophys Res Comm 2016;470:168–74. Kaczmarek R Duk M Szymczak K , Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens . Biochem Biophys Res Comm 2016 ; 470 : 168 – 74 . 10.1016/j.bbrc.2016.01.017 Search in Google Scholar

6. Haselberger SG, Schenkel-Brunner H. Evidence for erythrocyte membrane glycoproteins being carriers of blood-group P1 determinants. FEBS Lett 1982;149:126–8. Haselberger SG Schenkel-Brunner H. Evidence for erythrocyte membrane glycoproteins being carriers of blood-group P₁ determinants . FEBS Lett 1982 ; 149 : 126 – 8 . 10.1016/0014-5793(82)81086-7 Search in Google Scholar

7. Yang Z, Bergström J, Karlsson K-A. Glycoproteins with Galalpha4Gal are absent from human erythrocyte membranes, indicating that glycolipids are the sole carriers of blood group P activities. J Biol Chem 1994;269:14620–4. Yang Z Bergström J Karlsson K-A. Glycoproteins with Galalpha4Gal are absent from human erythrocyte membranes, indicating that glycolipids are the sole carriers of blood group P activities . J Biol Chem 1994 ; 269 : 14620 – 4 . 10.1016/S0021-9258(17)36669-3 Search in Google Scholar

8. Stenfelt L, Westman JS, Hellberg A, Olsson ML. The P1 histo-blood group antigen is present on human red blood cell glycoproteins. Transfusion 2019;59:1108–17. Stenfelt L Westman JS Hellberg A Olsson ML. The P1 histo-blood group antigen is present on human red blood cell glycoproteins . Transfusion 2019 ; 59 : 1108 – 17 . 10.1111/trf.1511530597575 Search in Google Scholar

9. Szymczak-Kulus K, Weidler S, Bereznicka A, et al. Novel bisgalactosylated type of N-glycans as decoy receptors for Shiga toxin? Glycoconj J 2019;36:369. Szymczak-Kulus K Weidler S Bereznicka A , Novel bisgalactosylated type of N-glycans as decoy receptors for Shiga toxin? Glycoconj J 2019 ; 36 : 369 . Search in Google Scholar

10. Tsering D, Chen C, Ye J, et al. Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr Res 2017;438:39–43. Tsering D Chen C Ye J , Enzymatic synthesis of human blood group P1 pentasaccharide antigen . Carbohydr Res 2017 ; 438 : 39 – 43 . 10.1016/j.carres.2016.11.01927960098 Search in Google Scholar

11. Jacob F, Alam S, Konantz M, et al. Transition of mesenchymal and epithelial cancer cells depends on alpha1-4 galactosyltransferase-mediated glycosphingolipids. Cancer Res 2018;78:2952–65. Jacob F Alam S Konantz M , Transition of mesenchymal and epithelial cancer cells depends on alpha1-4 galactosyltransferase-mediated glycosphingolipids . Cancer Res 2018 ; 78 : 2952 – 65 . 10.1158/0008-5472.CAN-17-222329572228 Search in Google Scholar

12. Breton C, Snajdrova L, Jeanneau C, Koca J, Imberty A. Structures and mechanisms of glycosyltransferases. Glycobiology 2006;16:29R–37R. Breton C Snajdrova L Jeanneau C Koca J Imberty A. Structures and mechanisms of glycosyltransferases . Glycobiology 2006 ; 16 : 29R – 37R . 10.1093/glycob/cwj01616037492 Search in Google Scholar

13. Pacheco AR, Lazarus JE, Sit B, et al. CRISPR screen reveals that EHEC’s T3SS and shiga toxin rely on shared host factors for infection. MBio 2018;9:e011003–18. Pacheco AR Lazarus JE Sit B , CRISPR screen reveals that EHEC’s T3SS and shiga toxin rely on shared host factors for infection . MBio 2018 ; 9 : e011003 – 18 . 10.1128/mBio.01003-18601624329921669 Search in Google Scholar

14. Tian S, Muneeruddin K, Choi MY, et al. Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biol 2018;16:e2006951. Tian S Muneeruddin K Choi MY , Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation . PLoS Biol 2018 ; 16 : e2006951 . 10.1371/journal.pbio.2006951625847230481169 Search in Google Scholar

15. Yamaji T, Sekizuka T, Tachida Y, et al. A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors. iScience 2019;11:409–24. Yamaji T Sekizuka T Tachida Y , A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors . iScience 2019 ; 11 : 409 – 24 . 10.1016/j.isci.2018.12.039634830330660999 Search in Google Scholar

16. Cabrita MA, Hobman TC, Hogue DL, King KM, Cass CE. Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes. Cancer Res 1999;59:4890–7. Cabrita MA Hobman TC Hogue DL King KM Cass CE. Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes . Cancer Res 1999 ; 59 : 4890 – 7 . Search in Google Scholar

17. Möller M, Jöud M, Storry JR, Olsson ML. Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project. Blood Adv 2016;1:240–9. Möller M Jöud M Storry JR Olsson ML. Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project . Blood Adv 2016 ; 1 : 240 – 9 . 10.1182/bloodadvances.2016001867573716829296939 Search in Google Scholar

18. Shastry S, Satyamoorthy K, Acharya KV, et al. Deletion in the A4GALT gene associated with rare “P null” phenotype: the first report from India. Transfus Med Hemother 2020;47:186–9. Shastry S Satyamoorthy K Acharya KV , Deletion in the A4GALT gene associated with rare “P null” phenotype: the first report from India . Transfus Med Hemother 2020 ; 47 : 186 – 9 . 10.1159/000501916718482532355479 Search in Google Scholar

19. Tilley L, McNeill A, Baglow L, et al. Two novel A4GALT null alleles detected in patients with the p phenotype (abstract). Br Blood Transfus Soc Ann Conf 2019;127. Tilley L McNeill A Baglow L , Two novel A4GALT null alleles detected in patients with the p phenotype (abstract) . Br Blood Transfus Soc Ann Conf 2019 ; 127 . Search in Google Scholar

20. Westman JS, Hellberg Å, Peyrard T, Thuresson B, Olsson ML. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles. Transfusion 2014;54:1831–5. Westman JS Hellberg Å, Peyrard T Thuresson B Olsson ML. Large deletions involving the regulatory upstream regions of A4GALT give rise to principally novel P1PK-null alleles . Transfusion 2014 ; 54 : 1831 – 5 . 10.1111/trf.1254324417201 Search in Google Scholar

21. Thuresson B, Westman JS, Olsson ML. Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups. Blood 2011;117:678–87. Thuresson B Westman JS Olsson ML. Identification of a novel A4GALT exon reveals the genetic basis of the P₁/P₂ histo-blood groups . Blood 2011 ; 117 : 678 – 87 . 10.1182/blood-2010-08-30133320971946 Search in Google Scholar

22. Lai YJ, Wu WY, Yang CM, et al. A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P1/P2 blood groups. Transfusion 2014;54:3222–31. Lai YJ Wu WY Yang CM , A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P₁/P₂ blood groups . Transfusion 2014 ; 54 : 3222 – 31 . 10.1111/trf.1277125041587 Search in Google Scholar

23. Iwamura K, Furukawa K, Uchikawa M, et al. The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene: a clue to the solution of the P1/P2/p puzzle. J Biol Chem 2003;278:44429–38. Iwamura K Furukawa K Uchikawa M , The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene: a clue to the solution of the P1/P2/p puzzle . J Biol Chem 2003 ; 278 : 44429 – 38 . 10.1074/jbc.M30160920012888565 Search in Google Scholar

24. Eernstman J, Veldhuisen B, Heshusius S, et al. KLF1 regulates P1 expression through transcriptional control of A4GALT. Vox Sang 2017;112:25(3B-S06-2). Eernstman J Veldhuisen B Heshusius S , KLF1 regulates P1 expression through transcriptional control of A4GALT . Vox Sang 2017 ; 112 : 25(3B-S06-2) . Search in Google Scholar

25. Singleton BK, Burton NM, Green C, Brady RL, Anstee DJ. Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype. Blood 2008;112:2081–8. Singleton BK Burton NM Green C Brady RL Anstee DJ. Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype . Blood 2008 ; 112 : 2081 – 8 . 10.1182/blood-2008-03-14567218487511 Search in Google Scholar

26. Kawai M, Obara K, Onodera T, et al. Mutations of the KLF1 gene detected in Japanese with the In(Lu) phenotype. Transfusion 2017;57:1072–7. Kawai M Obara K Onodera T , Mutations of the KLF1 gene detected in Japanese with the In(Lu) phenotype . Transfusion 2017 ; 57 : 1072 – 7 . 10.1111/trf.1399028194794 Search in Google Scholar

27. Westman JS, Stenfelt L, Vidovic K, et al. Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT. Blood 2018;131:1611–6. Westman JS Stenfelt L Vidovic K , Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT . Blood 2018 ; 131 : 1611 – 6 . 10.1182/blood-2017-08-80308029438961 Search in Google Scholar

28. Yeh CC, Chang CJ, Twu YC, et al. The differential expression of the blood group P(1)-A4GALT and P(2)-A4GALT alleles is stimulated by the transcription factor early growth response 1. Transfusion 2018;58:1054–64. Yeh CC Chang CJ Twu YC , The differential expression of the blood group P(1)-A4GALT and P(2)-A4GALT alleles is stimulated by the transcription factor early growth response 1 . Transfusion 2018 ; 58 : 1054 – 64 . 10.1111/trf.1451529399809 Search in Google Scholar

29. Kaczmarek R, Szymczak-Kulus K, Bereznicka A, et al. Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system. PLoS One 2018;13:e0196627. Kaczmarek R Szymczak-Kulus K Bereznicka A , Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system . PLoS One 2018 ; 13 : e0196627 . 10.1371/journal.pone.0196627592744429709005 Search in Google Scholar

30. Levine P. Illegitimate blood group antigens P1, A, and MN (T) in malignancy—a possible therapeutic approach with anti-Tja, anti-A, and anti-T. Ann N Y Acad Sci 1976;277:428–35. Levine P. Illegitimate blood group antigens P₁, A, and MN (T) in malignancy—a possible therapeutic approach with anti-Tj^a, anti-A, and anti-T . Ann N Y Acad Sci 1976 ; 277 : 428 – 35 . 10.1111/j.1749-6632.1976.tb41719.x793484 Search in Google Scholar

31. Jacob F, Goldstein DR, Bovin NV, et al. Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array. Int J Cancer 2012;130:138–46. Jacob F Goldstein DR Bovin NV , Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array . Int J Cancer 2012 ; 130 : 138 – 46 . 10.1002/ijc.26002313766721351089 Search in Google Scholar

32. Jacob F, Anugraham M, Pochechueva T, et al. The glycosphingolipid P(1) is an ovarian cancer-associated carbohydrate antigen involved in migration. Br J Cancer 2014;111:1634–45. Jacob F Anugraham M Pochechueva T , The glycosphingolipid P(1) is an ovarian cancer-associated carbohydrate antigen involved in migration . Br J Cancer 2014 ; 111 : 1634 – 45 . 10.1038/bjc.2014.455420009525167227 Search in Google Scholar

33. Puri A, Rawat SS, Lin HM, et al. An inhibitor of glycosphingolipid metabolism blocks HIV-1 infection of primary T-cells. AIDS 2004;18:849–58. Puri A Rawat SS Lin HM , An inhibitor of glycosphingolipid metabolism blocks HIV-1 infection of primary T-cells . AIDS 2004 ; 18 : 849 – 58 . 10.1097/00002030-200404090-0000215060432 Search in Google Scholar

34. Hammache D, Yahi N, Maresca M, Pieroni G, Fantini J. Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3). J Virol 1999;73:5244–8. Hammache D Yahi N Maresca M Pieroni G Fantini J. Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3) . J Virol 1999 ; 73 : 5244 – 8 . 10.1128/JVI.73.6.5244-5248.199911257810233996 Search in Google Scholar

35. Lund N, Olsson ML, Ramkumar S, et al. The human P(k) histo-blood group antigen provides protection against HIV-1 infection. Blood 2009;113:4980–91. Lund N Olsson ML Ramkumar S , The human P(k) histo-blood group antigen provides protection against HIV-1 infection . Blood 2009 ; 113 : 4980 – 91 . 10.1182/blood-2008-03-14339619139081 Search in Google Scholar

36. Motswaledi MS, Kasvosve I, Oguntibeju OO. Blood group antigens C, Lub and P1 may have a role in HIV infection in Africans. PLoS One 2016;11:e0149883. Motswaledi MS Kasvosve I Oguntibeju OO. Blood group antigens C, Lub and P1 may have a role in HIV infection in Africans . PLoS One 2016 ; 11 : e0149883 . 10.1371/journal.pone.0149883476429526900853 Search in Google Scholar