<abstract xmlns="http://www.w3.org/1999/xhtml">Blood samples from a 10-month-old male infant requiring transfusion were found to contain an alloantibody reacting at 37°C in saline, by indirect antiglobulin test (IAT), and with a manual polybrene technique. Preliminary results suggested anti-D and another weaker reacting antibody, but the patient had been previously transfused with only D– blood. His serum reacted more weakly by IAT against red cells treated with 0.2M dithiothreitol (DTT), and one D+, LW(a–) sample was nonreactive. The patient’s red blood cells (RBCs) typed as B, D–, LW(a–), K–, Fy(a–). Due to the age and clinical status of the child, 51Cr survival studies were not performed. One pediatric unit of D–, K–, Fy(a–) blood was transfused uneventfully; the expected increment of hemoglobin was achieved. Repeat testing 3 months later showed a weakly positive DAT, the patient’s RBCs typed as LW(a+), and anti-LWa was detected only by a two-stage papain technique. These results suggest that the patient had a transient depression of LWa with a concurrent anti-LWa. <bold><italic>Immunohematology</italic></bold> 1994;10:127–129.</abstract>

Blood samples from a 10-month-old male infant requiring transfusion were found to contain an alloantibody reacting at 37°C in saline, by indirect antiglobulin test (IAT), and with a manual polybrene technique. Preliminary results suggested anti-D and another weaker reacting antibody, but the patient had been previously transfused with only D– blood. His serum reacted more weakly by IAT against red cells treated with 0.2M dithiothreitol (DTT), and one D+, LW(a–) sample was nonreactive. The patient’s red blood cells (RBCs) typed as B, D–, LW(a–), K–, Fy(a–). Due to the age and clinical status of the child, 51Cr survival studies were not performed. One pediatric unit of D–, K–, Fy(a–) blood was transfused uneventfully; the expected increment of hemoglobin was achieved. Repeat testing 3 months later showed a weakly positive DAT, the patient’s RBCs typed as LW(a+), and anti-LWa was detected only by a two-stage papain technique. These results suggest that the patient had a transient depression of LWa with a concurrent anti-LWa. Immunohematology 1994;10:127–129.

An example of anti-LWa in a 10-month-old infant

Immunohematology

An example of anti-LW in a 10-month-old infant

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Blood samples from a 10-month-old male infant requiring transfusion were found to contain an alloantibody reacting at 37°C in saline, by indirect antiglobulin...

An example of anti-LW^a in a 10-month-old infant

Publié en ligne: 30 nov. 2020

Pages: 127 - 129

DOI: https://doi.org/10.21307/immunohematology-2019-938

© 1994 A. Devenish et al., published by Sciendo