<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Plasma from a 35-year-old, D– woman was found to have anti-D, -C, and -G at 5 weeks’ gestation and again at 8 weeks’ gestation, when she presented with a nonviable intrauterine pregnancy. The anti-D titer increased with a pattern that suggested it was stimulated by the 8-week pregnancy. Six years before this admission, the patient’s blood type changed from group O, D+ to group O, D– after a bone marrow transplant for aplastic anemia. Three years after transplant, the antibody screen was negative. After the patient was admitted for the nonviable pregnancy, the products of con-ception were found to be D+ by DNA testing for <italic>RHD.</italic> There were no documented transfusions or pregnancies during the interval in which anti-D appeared. The timing of the alloimmunization was unusual. In a subsequent pregnancy, fetal D typing was performed by molecular methods. <italic><bold>Immunohematology</bold></italic><bold>2012;28:55–9.</bold></p></abstract>

Plasma from a 35-year-old, D– woman was found to have anti-D, -C, and -G at 5 weeks’ gestation and again at 8 weeks’ gestation, when she presented with a nonviable intrauterine pregnancy. The anti-D titer increased with a pattern that suggested it was stimulated by the 8-week pregnancy. Six years before this admission, the patient’s blood type changed from group O, D+ to group O, D– after a bone marrow transplant for aplastic anemia. Three years after transplant, the antibody screen was negative. After the patient was admitted for the nonviable pregnancy, the products of con-ception were found to be D+ by DNA testing for RHD. There were no documented transfusions or pregnancies during the interval in which anti-D appeared. The timing of the alloimmunization was unusual. In a subsequent pregnancy, fetal D typing was performed by molecular methods. Immunohematology2012;28:55–9.

Posttransplant maternal anti-D: a case study and review

Immunohematology

{"article-title":"Posttransplant maternal anti-D: a case study and review"}

Plasma from a 35-year-old, D– woman was found to have anti-D, -C, and -G at 5 weeks’ gestation and again at 8 weeks’ gestation, when she presented with a...

Posttransplant maternal anti-D: a case study and review

Article Category: Case Report

Publié en ligne: 01 déc. 2019

Pages: 55 - 59

DOI: https://doi.org/10.21307/immunohematology-2019-150

© 2012 L. Senzel, et al., published by Sciendo