<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Although antibodies to antigens in the Rh blood group system are common causes of warm autoimmune hemolytic anemia, specificity for only the D antigen is rare in autoimmune hemolysis in pediatric patients. This case reports an anti-D associated with severe hemolytic anemia (Hb = 2.1 g/dL) in a previously healthy 14-month-old child who presented with a 3-day history of low-grade fevers and vomiting. Because of his severe anemia, on admission to the hospital he was found to have altered mental status, metabolic acidosis, abnormal liver function tests, and a severe coagulopathy. He was successfully resuscitated with uncrossmatched units of group O, D– blood, and after corticosteroid therapy he had complete resolution of his anti-D-mediated hemolysis. <italic><bold>Immunohematology</bold></italic><bold>2013;29:15–18.</bold></p></abstract>

Although antibodies to antigens in the Rh blood group system are common causes of warm autoimmune hemolytic anemia, specificity for only the D antigen is rare in autoimmune hemolysis in pediatric patients. This case reports an anti-D associated with severe hemolytic anemia (Hb = 2.1 g/dL) in a previously healthy 14-month-old child who presented with a 3-day history of low-grade fevers and vomiting. Because of his severe anemia, on admission to the hospital he was found to have altered mental status, metabolic acidosis, abnormal liver function tests, and a severe coagulopathy. He was successfully resuscitated with uncrossmatched units of group O, D– blood, and after corticosteroid therapy he had complete resolution of his anti-D-mediated hemolysis. Immunohematology2013;29:15–18.

A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child

Immunohematology

Although antibodies to antigens in the Rh blood group system are common causes of warm autoimmune hemolytic anemia, specificity for only the D antigen is rare...

A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child

Article Category: Case Report

Publié en ligne: 01 déc. 2019

Pages: 15 - 118

DOI: https://doi.org/10.21307/immunohematology-2019-118

© 2013 R.S. Bercovitz, et al., published by Sciendo