Ropivacaine – its pharmacology, properties, and clinical use within orofacial tissues with a particular focus on dental practice

Ropivacaine is a long-acting local anaesthetic from the aminoamide drug class. Synthesized in 1957, it was brought into clinical practice at the end of the 20th century. The drug is used in medicine, especially in the field of general surgery and obstetrics. Unlike structurally akin bupivacaine, which is also sold in cartridges for carpule-type syringes popular in dental practice, no dental formulations of ropivacaine are available to this day. The paper presents the characteristics of ropivacaine and its properties. Particular emphasis is placed on the possible use of ropivacaine within orofacial tissues. Data from trials in dental settings conducted in the past 2 decades were discussed, with implications important for dentists. The drug may be a suitable option for time-consuming oral procedures, particularly when prolonged postoperative analgesia is desirable.

Ropivacaine, with its efficacy, lower propensity for motor block, and reduced potential for central nervous system (CNS) toxicity and cardiotoxicity compared to other long-acting drugs from the class, is an important alternative in regional anaesthesia and the management of postoperative pain and, as such, should not be overlooked in dental practice.