Coefficient | Interpretation | Numerical value |
---|---|---|
Inverse transit time through | 0.197 | |
Inverse transit time through | 0.356 | |
Initial condition for | 0.7012 | |
Initial condition for | 0.2988 | |
Maximum dose rate/concentration effectiveness of the drug | 0.90 | |
Penalty/weight for the total dose of cytotoxic agent | 0.50 | |
Penalty/weight in the objective for the average number of cancer cells in | 0.10 | |
Penalty/weight in the objective for the average number of cancer cells in | 0.10 | |
Penalty/weight in the objective for the average number of cancer cells in | 3 | |
Penalty/weight in the objective for the average number of cancer cells in | 3 | |
Therapy horizon |
Variable | Value (Units) |
---|---|
0.924 mm | |
42.3 mm | |
0 mm | |
100 mm | |
0.114 mo | |
0.0226 mo | |
0.0045 mo | |
0.0214 mo | |
0.842 |
Variable | Description | Value (Units) |
---|---|---|
Tumor growth parameter | 0.084 day | |
Tumor-induced stimulation parameter | 5.85 day | |
Tumor-induced inhibition parameter | 0.00873 mm | |
Loss of vascular support | 0.02 day | |
Maduration of unstable vessels parameter | 0.025 day | |
Anti-angiogenic elimination parameter | 0.15 kg/mg day | |
Cytotoxic killing parameter for the tumor | 0.1 kg/mg day |
Coefficient | Interpretation | Numerical value |
---|---|---|
Inverse transit time through | 0.197 | |
Inverse transit time through | 0.395 | |
Inverse transit time through | 0.107 | |
Initial condition for | 0.3866 | |
Initial condition for | 0.1722 | |
Initial condition for | 0.4412 | |
Maximum dosage/concentration/effectiveness of cytotoxic agent | 0.95 | |
Maximum blocking effect of cytostatic agent | 0.30 | |
Penalty/weight at the cytotoxic agent | 1 | |
Penalty/weight at the cytostatic agent | 0.01 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 0.1 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 0.1 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 0.1 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 8.25 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 8.25 | |
Penalty/weight in the objective for the average number of cancer cells in | 1, resp. 8.25 | |
Therapy horizon |
Coefficient | Interpretation | Numerical value |
---|---|---|
Inverse transit time through | 0.05 | |
Inverse transit time through | 0.5 | |
Inverse transit time through | 1 | |
Probability that cells enter | 0.9 | |
Probability that cells enter | 0.1 | |
Initial condition for | 0.8589 | |
Initial condition for | 0.0954 | |
Initial condition for | 0.0456 | |
Maximum dose rate/concentration effectiveness | 0.95 | |
Maximum dose rate/concentration effectiveness | 6 | |
Penalty/weight at the cytotoxic agent | 1 | |
Penalty/weight at the recruiting agent | 0, 0.1 | |
Penalty/weight in the objective for the average number of cancer cells in | 3 | |
Penalty/weight in the objective for the average number of cancer cells in | 1 | |
Penalty/weight in the objective for the average number of cancer cells in | 1 | |
Penalty/weight in the objective for the average number of cancer cells in | 3 | |
Penalty/weight in the objective for the average number of cancer cells in | 1 | |
Penalty/weight in the objective for the average number of cancer cells in | 1 | |
Therapy horizon |