(Intercept) | 1.6536*** (1.3891, 1,9794) | 1.5907*** (1.4018, 1.808) | 2.4910*** (1.5097, 4.0477 | 2.4330*** (1.5911, 3.6499) | 0.2292* (0.0524, 0.8669) | 0.2959* (0.1195, 0.7238) |
Age | 0.9981 (0.9956, 1.0006) | — | 0.9984 (0.9927, 1.004) | — | 1.0199*** (1.0088, 1.0309) | 1.0214*** (1.0110, 1.0317) |
Having a target joint | 0.9679 (0.9147, 1.0242) | — | 1.6486*** (1.3995, 1.9484) | 1.6573*** (1.4130, 1.9506) | 2.2315*** (1.5382, 2.2098) | 2.3001*** (1.59.88, 3.3808) |
Primary prophylaxis (vs secondary) | 1.0497* (0.9979, 1.1039) | 1.0447* (0.9943, 1.0973) | 0.9601 (0.8439, 1.0938) | — | 0.9992 (0.7624, 1.3190) | — |
Number of concomitant diseases | 1.0051 (0.9790, 1.0324) | — | 1.0298 (0.9740, 1.0873) | — | 1.0356 (0.9330, 1.1451) | — |
Number of hospitalisations | 0.9647* (0.9329, 0.9977) | 0.9612* (0.9306, 0.9932) | 1.0712*** (1.0357, 1.1064) | 1.0683*** (1.0377, 1.0976) | 1.0588 (0.9920, 1.1266) | 1.0541 (0.9901, 1.1181) |
High adherence | 0.9917 (0.9446, 1.0411) | — | 0.8554* (0.7512, 0.9753) | 0.8463* (0.7444, 0.9631) | 0.6817** (0.5198, 0.8955) | 0.6723** (0.5141, 0.8804) |
Having haemophilia B | 0.9996 (0.9275, 1.0790) | — | 1.0222 (0.853, 1.2179) | — | 0.6977 (0.4408, 1.0620) | 0.6877 (0.4345, 1.0435) |
Increasing infusion rate/year | 0.9999 (0.9989, 1.0009) | 0.9997 (0.9988, 1.0007) | 0.9968* (0.9936, 1.0000) | 0.9967* (0.9936, 0.9999) | 0.9977 ((0.9885, 1.0073) | 0.9955* (0.9921, 0.9989) |
Mild chronic pain | 0.9271 (0.7602, 1.1201) | 0.8824 (0.7349, 1.0577) | 1.0762 (0.6296, 1.9593) | 1.0988 (0.6300, 1.9316) | 2.6814 (0.6259, 12.7098) | 2.1879*** (1.4188, 3.4933) |
Moderate chronic pain | 0.8994 (0.6869, 1.1756) | 0.8344 (0.6590, 1.0556) | 1.8156** (1.0213, 3.2642) | 1.8877** (1.0723, 3.3572) | 4.2172* (0.9855, 20.1387) | 3.308*** (2.0707, 5.4543) |
Severe chronic pain | 0.1826*** (0.0969, 0.3437) | 0.1788*** (0.1217, 0.2664) | 2.5249 (0.6292, 9.6216) | 3.6750* (1.1677, 10.6275) | 4.3910 (0.4313, 45.1077) | 3.8228*** (1.9093, 7.545) |
Infusion rate/year * mild chronic pain | 1.0000 (0.9987, 1.0014) | 1.0002 (0.9989, 1.0016) | 1.0023 (0.9981, 1.0065) | 1.0024 (0.9982, 1.0065) | 0.9983 (0.9872, 1.0094) | — |
Infusion rate/year * moderate chronic pain | 0.9996 (0.998, 1.0012) | 0.9999 (0.9985, 1.0014) | 0.9968 (0.9968, 1.0048) | 1.0007 (0.9967, 10046) | 1.0007 (0.9967, 10046) | — |
Infusion rate/year * severe chronic pain | 1.0045* (1.0003, 1.0087) | 1.0045** (1.0015, 1.0075) | 0.9950 (0.9853, 1.0046) | 0.9928* (0.9841, 1.0014) | 0.9978 (0.9819, 1.10135) | — |