Blood pressure in haemophilia and its relation to clotting factor usage
Srila Gopal
Hemostasis and Thrombosis, Department of Medicine, University of California San DiegoSan Diego, USA
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, Richard FW Barnes
Hemophilia and Thrombosis Treatment Center, Department of Medicine, University of California San DiegoSan Diego, USA
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, Doris V Quon
Orthopaedic Hemophilia Treatment Center, Orthopaedic Institute for ChildrenLos Angeles, USA
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, , et Annette von Drygalski
- Hemophilia and Thrombosis Treatment Center, Department of Medicine, University of California San DiegoSan Diego, USA
- Department of Molecular Medicine, The Scripps Research Institute, Department of Molecular MedicineLa Jolla, USA
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23 déc. 2019
À propos de cet article
Catégorie d'article: Clinical Research
Publié en ligne: 23 déc. 2019
Pages: 42 - 50
DOI: https://doi.org/10.17225/jhp00147
Mots clés
© 2019 Srila Gopal, Richard FW Barnes, Doris V Quon, Hao Wei (Linda) Sun, Shannon Jackson, Annette von Drygalski, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1A
Figure 1B
Figure 1C
Figure 2A
Figure 2B
Figure 2C
Hypertension categories based on American Heart Association guidelines, 2017
| CATEGORY | BP RANGE (MM HG) | NUMBER | % |
|---|---|---|---|
| Normal | < 120/ 80 mm Hg | 54 | 28 |
| Elevated | SBP 12-129 mm Hg | 53 | 27 |
| Hypertension | SBP 130-139 or DBP | 58 | 30 |
| Hypertension | SBP > 139 mm Hg or | 28 | 15 |
3B_ Regression coefficients for systolic blood pressure, adjusted for logBMI
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.19 | -1.45, 0.70 | 0.236 | 0.634 |
| 0.5 Median | -0.05 | -0.89, 1.30 | 0.235 | 0.704 |
| 0.9 Upper | -0.29 | -3.05, 2.63 | 0.213 | 0.672 |
3C_ Regression coefficients for diastolic blood pressure (unadjusted)
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.65 | -1.26, -0.21 | 0.044 | 0.002 |
| 0.5 Median | 0.00 | -1.31, 0.70 | 0.000 | 0.523 |
| 0.9 Upper | -0.39 | -2.19, 1.29 | 0.009 | 0.596 |
Demographic characteristics of patients by factor use category
| MEDIAN (IQR) | COMPARISON OF PROPHYLAXIS | |||
|---|---|---|---|---|
| ALL PATIENTS | PROPHYLAXIS | ON DEMAND | AND ON-DEMAND PATIENTS, WILCOXON W (P) | |
| Age (years) | 30 (25, 41) | 30 (25, 38) | 37 (26, 49) | 4510 (0.010) |
| Systolic BP (mmHg) | 125 (118, 133) | 124 (118, 132) | 125 (115, 134) | 3706 (0.953) |
| Diastolic BP (mmHg) | 76 (71, 82) | 76 (71, 81) | 78 (71, 85) | 3950 (0.462) |
| BMI (kg/m2) | 24.5 (22.0, 27.8) | 24.5 (22.4, 27.8) | 24.4 (21.4, 28.7) | 2878 (0.995) |
| Factor usage | 3651 (1705, 5771) | 4179 (2889, 6551) | 818 (485, 1409) | 1341 (<0.001) |
Quantile regression for systolic and diastolic blood pressure on factor usage for patients on prophylaxisThe regression coefficients for the 0_1 (lower), 0_5 (median) and 0_9 (upper) quantiles are shown_3A_ Regression coefficients for systolic blood pressure (unadjusted)
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.29 | -1.68, 0.38 | 0.004 | 0.366 |
| 0.5 Median | -0.57 | -1.43, 0.13 | 0.012 | 0.146 |
| 0.9 Upper | -0.75 | -3.43, 0.75 | 0.001 | 0.378 |
3D_ Regression coefficients for diastolic blood pressure, adjusted for logBMI and HCV
| QUANTILE | REGRESSION COEFFICIENT X 10-3 | 95% CI X 10-3 | R1 | P |
|---|---|---|---|---|
| 0.1 Lower | -0.67 | -1.33, -0.19 | 0.254 | 0.061 |
| 0.5 Median | -0.24 | -0.65, 0.51 | 0.261 | 0.914 |
| 0.9 Upper | -0.01 | -2.59, 2.18 | 0.266 | 0.698 |