<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Immersion pulmonary oedema, also referred to as swimming-induced pulmonary oedema, is a form of pulmonary oedema which usually occurs during swimming in cold water. The condition is most common in triathlon athletes; it was first reported in military divers. The main symptoms include acute dyspnoea, cough, and occasionally haemoptysis, which usually subside within approximately 48 hours. The pathomechanism is not fully understood, but oedema is suspected to be due to an increased systemic vascular resistance that overloads the left ventricle. The diagnostic process can be challenging and require multiple stages to rule out a number of other possible conditions. In view of the circumstances in which incidents typically occur, immersion pulmonary oedema poses an immediate life threat to individuals involved in selected forms of physical activity, where survival is often determined by appropriate training of medical services.</p>
</abstract>

Immersion pulmonary oedema, also referred to as swimming-induced pulmonary oedema, is a form of pulmonary oedema which usually occurs during swimming in cold water. The condition is most common in triathlon athletes; it was first reported in military divers. The main symptoms include acute dyspnoea, cough, and occasionally haemoptysis, which usually subside within approximately 48 hours. The pathomechanism is not fully understood, but oedema is suspected to be due to an increased systemic vascular resistance that overloads the left ventricle. The diagnostic process can be challenging and require multiple stages to rule out a number of other possible conditions. In view of the circumstances in which incidents typically occur, immersion pulmonary oedema poses an immediate life threat to individuals involved in selected forms of physical activity, where survival is often determined by appropriate training of medical services.


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<sec id="j_jou.2021.0041_s_001" sec-type="other">
<div>Case report</div>
<p>We present the case of a 48-year-old female triathlete who had a sudden attack of severe dyspnoea during an amateur sports competition. The incident happened in a lake (air temperature: 21C, water temperature: 17C) in August 2020. After the triathlete swam a distance of 200–300 m she developed severe shortness of breath, which made it impossible to continue competing.</p>
<p>The woman was pulled out of the water by emergency services; she categorically denied aspiration of water. Despite the cessation of physical activity the complaints persisted, and the triathlete experienced considerable weakness and confusion. Crackling sounds could be heard above the lungs. The level of capillary saturation was 84%. Oxygen therapy, intravenous furosemide and inhaled salbutamol were administered, and the athlete was transported to hospital.</p>
<p>The electrocardiogram was normal. Chest radiography (X-ray) revealed areas of marked parenchymal thickening in the lower and middle lung fields bilaterally (<a ref-type="fig" href="#j_jou.2021.0041_fig_001">Fig. 1A</a>). Laboratory tests showed significantly elevated levels of cardiac troponin T (cTnI) (1048 ng/l; normal range &lt;16 ng/l), B-type natriuretic peptide (BNP) (6001.6 pg/ml; normal range &lt;125 pg/ml), and D-dimer (DD) (2555 ng/ml; normal range &lt;550 ng/ml). The results of a molecular test (real-time polymerase chain reaction, RT-PCR) and an assay to detect SARS-CoV-2 antibodies were negative. Angiographic evaluation of the thoracic arteries ruled out pulmonary embolism and thoracic aortic pathologies. At the same time, diffuse ground-glass opacities were seen in the pulmonary parenchyma (<a ref-type="fig" href="#j_jou.2021.0041_fig_002">Fig. 2A</a>).</p>
<figure id="j_jou.2021.0041_fig_001" position="float" fig-type="figure">
<h2>Fig. 1.</h2>
<figCaption>
<p>Chest radiography findings at three different time points during the period of patient care. <bold>A.</bold> Examination performed in the emergency department (Day 0) – marked parenchymal changes involving the middle and lower lung fields. <bold>B.</bold> Another day of hospitalisation (Day 3) – clear regression of parenchymal lesions. <bold>C.</bold> Long-term evaluation after the original incident (Day 30) – complete resolution of parenchymal lesions</p>
</figCaption>
<img xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_jou.2021.0041_fig_001.jpg" src="https://sciendo-parsed.s3.eu-central-1.amazonaws.com/64722e23215d2f6c89dbec00/j_jou.2021.0041_fig_001.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20240708T162031Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=18000&amp;X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240708%2Feu-central-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=ed70fe82c4ea094d15adda40b4b7586d65efeef558bfee51e1c2689cf8c7b3c6" class="mw-100"/>
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<figure id="j_jou.2021.0041_fig_002" position="float" fig-type="figure">
<h2>Fig. 2.</h2>
<figCaption>
<p>Chest CT scan dedicated to the assessment of pulmonary parenchyma – high-resolution computed tomography (HRCT) (<bold>A</bold>). Comparative concurrent lung ultrasound examination performed with a linear transducer (<bold>B, C</bold>). <bold>A.</bold> CT scan revealing extensive ground-glass parenchymal opacities. <bold>B, C.</bold> Lung ultrasound showing diffuse B-lines. The red arrowhead shows the approximate location where the linear was applied. A clear correlation is seen between B-lines and ground-glass opacities</p>
</figCaption>
<img xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_jou.2021.0041_fig_002.jpg" src="https://sciendo-parsed.s3.eu-central-1.amazonaws.com/64722e23215d2f6c89dbec00/j_jou.2021.0041_fig_002.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20240708T162031Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=18000&amp;X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240708%2Feu-central-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=76f460052f3297dc1724017c552204786cb9fef50fc532ae85e3720600838c85" class="mw-100"/>
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<p>The crackles over the lower lung fields persisted on the following day of hospitalisation. Lung ultrasound (LUS) was performed, showing the presence of B-lines (<a ref-type="fig" href="#j_jou.2021.0041_fig_002">Fig. 2B</a> and <a ref-type="fig" href="#j_jou.2021.0041_fig_002">Fig. 2C</a>). Echocardiography revealed a moderately enlarged right ventricular cavity – RVA/LVA (right/left ventricular analysis) = 1.03 (<a ref-type="fig" href="#j_jou.2021.0041_fig_003">Fig. 3A</a>). The left ventricular systolic and diastolic function was normal (ejection fraction, EF 65%). The parameters of the right ventricular systolic function were also within the normal range: TAPSE (tricuspid annular plane systolic excursion) 22 mm; there was a change in the right ventricular area (fractional area change, FAC; 42%). In addition, global longitudinal strain was measured (–24.5%) (<a ref-type="fig" href="#j_jou.2021.0041_fig_003">Fig. 3B</a>).</p>
<figure id="j_jou.2021.0041_fig_003" position="float" fig-type="figure">
<h2>Fig. 3.</h2>
<figCaption>
<p>Echocardiographic evaluation. <bold>A, C.</bold> Evaluation of the right and left ventricular relations at different time points during the period of patient care; a marked change in the ratio between the right and the left ventricle areas (RVS/LVA) over several days of follow-up (Day 1 vs Day 30) is noted. <bold>B, D.</bold> Assessment of right ventricular systolic function by tracking acoustic markers; compared to the baseline image (Day 0), there is a marked improvement in right ventricular free-wall longitudinal strain (Day 30). RV – right ventricle; LV – left ventricle; RVA – right ventricle area; LVA – left ventricle area</p>
</figCaption>
<img xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_jou.2021.0041_fig_003.jpg" src="https://sciendo-parsed.s3.eu-central-1.amazonaws.com/64722e23215d2f6c89dbec00/j_jou.2021.0041_fig_003.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20240708T162031Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=18000&amp;X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240708%2Feu-central-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=93e3cdf09c5b71c525d521472992f2d641c06b8cded4e8a49a35c7d476b112bc" class="mw-100"/>
</figure>
<p>On the third hospital day, the patient did not report any complaints. Radiographic examination revealed regression of parenchymal lesions (<a ref-type="fig" href="#j_jou.2021.0041_fig_001">Fig. 1B</a>). The levels of cTnI (42 ng/l), BNP (1018 ng/ml), and DD (202 ng/ml), rapidly normalised. 24-hour Holter monitoring (ECG and blood pressure) found no abnormalities.</p>
<p>The patient was reassessed 30 days after the incident. Laboratory tests showed complete normalisation of cTnI (0 ng/l), BNP (97.8 pg/ml), and DD (104 ng/ml) levels. The patient’s chest X-ray showed no evidence of any abnormalities (<a ref-type="fig" href="#j_jou.2021.0041_fig_001">Fig. 1C</a>). Cardiac echocardiography revealed a significant improvement in the parameters of right ventricular morphology and function. In addition, RVA/LVA = 0.79 (previously: 1.03) (<a ref-type="fig" href="#j_jou.2021.0041_fig_003">Fig. 3C</a>). An improvement was observed in TAPSE – 26 mm, FAC – 52%, and right ventricular free-wall global longitudinal strain (–29.37%) (<a ref-type="fig" href="#j_jou.2021.0041_fig_003">Fig. 3D</a>).</p>
<p>Considering the fact that consequences of ischaemic heart disease are among the most common causes of death in athletes aged >35 years, the diagnostic work-up was extended in this direction. Cardiac stress scintigraphy (single-photon emission computed tomography, SPECT) was done, without any abnormalities (<a ref-type="fig" href="#j_jou.2021.0041_fig_004">Fig. 4</a> and <a ref-type="fig" href="#j_jou.2021.0041_fig_005">Fig. 5</a>).</p>
<figure id="j_jou.2021.0041_fig_004" position="float" fig-type="figure">
<h2>Fig. 4.</h2>
<figCaption>
<p>Assessment of myocardial perfusion by SPECT – rest and stress tests showing no significant ischaemia. Top bar: stress–rest cross-section images in the short axis; middle bar: stress–rest horizontal cross-section images in the long axis; bottom bar: stress–rest vertical cross-section images in the short axis. SA – short axis, VLA – vertical long axis, HLA – horizontal long axis</p>
</figCaption>
<img xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_jou.2021.0041_fig_004.jpg" src="https://sciendo-parsed.s3.eu-central-1.amazonaws.com/64722e23215d2f6c89dbec00/j_jou.2021.0041_fig_004.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20240708T162031Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=18000&amp;X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240708%2Feu-central-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=bbd79459382784063020250c8526e4dc2f497eaf5077191ac59121d5216ff649" class="mw-100"/>
</figure>
<figure id="j_jou.2021.0041_fig_005" position="float" fig-type="figure">
<h2>Fig. 5.</h2>
<figCaption>
<p>Cardiac imaging using 99mTc-methoxy-isobutyl-isonitrile; 3D-Gated display. <bold>A.</bold> At stress. <bold>B.</bold> At rest. <bold>C.</bold> No difference between rest and stress tests</p>
</figCaption>
<img xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/j_jou.2021.0041_fig_005.jpg" src="https://sciendo-parsed.s3.eu-central-1.amazonaws.com/64722e23215d2f6c89dbec00/j_jou.2021.0041_fig_005.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&amp;X-Amz-Date=20240708T162031Z&amp;X-Amz-SignedHeaders=host&amp;X-Amz-Expires=18000&amp;X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240708%2Feu-central-1%2Fs3%2Faws4_request&amp;X-Amz-Signature=9edf7a4ac55548c61efe296eb94d92a7e7194a11bb32a0f73c131447e1aaf464" class="mw-100"/>
</figure>
<p>Based on the overall clinical presentation and the results of additional examinations, the patient was diagnosed with immersion pulmonary oedema (IPO), also referred to as swimming-induced pulmonary oedema (SIPO), with features of acute right ventricular heart failure.</p>
</sec>
<sec id="j_jou.2021.0041_s_002" sec-type="discussion">
<div>Discussion</div>
<p>Triathlon is a physically demanding multi-sport discipline included in the group of endurance sports. It consists of three components: swimming (750–3800 m), cycling (13– 112 km), and running (5–42 km).</p>
<p>Regular physical activity is known to reduce overall mortality and the risk of cardiovascular death. At the same time, however, inappropriate types of physical activities may lead to serious health effects. The risk of sports-related death is 0.3–2.1 cases per 100,000 population/year; in young athletes (&lt;35 years of age) it is 0.3 cases per 100,000 population/year, while in older athletes it rises to 3 cases per 100,000 population/year. The risk is higher in men. In younger athletes, &lt;35 years of age, the main causes of death include cardiomyopathies and channelopathies, and the associated cardiac arrhythmias. In older athletes (aged >35 years), complications of ischaemic heart disease are the predominant type.</p>
<p>Compared to other sports, the risk of triathlon-related death is relatively high: 1.74 cases per 100,000 competitors (1.01 per 100,000 marathon runners). The majority of deaths in triathlon (67%) occur during the swimming stage. This may delay medical rescue efforts, so the aetiology of death remains unclear. Among the causes, IPO/SIPO have been proposed<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_001">1</a>)</sup>.</p>
<p>Immersion pulmonary oedema (IPO/SIPO) was first described in 1989 in divers experiencing cold water conditions (&lt;12C). The researchers concluded that the main predisposing factors included hypertension, female gender, and cold water<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_002">2</a>)</sup>.</p>
<p>The main symptoms are dyspnoea (79% of cases), cough (71%), less commonly haemoptysis, foamy sputum, chest pain/tightness, and wheezing. The disease is characterised by an acute onset of symptoms and their rapid resolution, usually within 48 hours<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_003">3</a>,<a ref-type="bibr" href="#j_jou.2021.0041_ref_004">4</a>)</sup>.</p>
<p>Establishing the correct diagnosis can be challenging and requires a combined diagnostic approach. The basic imaging examination is chest X-ray showing characteristic parenchymal densities and interstitial changes<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_005">5</a>)</sup>. Another diagnostically useful modality is LUS<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_006">6</a>)</sup>. It is capable of identifying lung oedema with high sensitivity (97%) and specificity (95%). The diagnosis is supported by interstitial syndrome manifested as B-predominance: the more B-lines are found, and the denser their arrangement, the greater the accumulation of fluid in the pulmonary parenchyma. “White lung” seen on LUS images is evidence for high severity of the condition<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_007">7</a>)</sup>.</p>
<p>In the acute phase, treatment involves elimination of the causative factor, and supplemental oxygen therapy, bronchodilator drugs, and diuretics. Also, spontaneous resolution of symptoms has been observed in some individuals with IPO/SIPO despite no treatment.</p>
<p>IPO/SIPO prevention should include the identification and treatment of predisposing conditions such as arterial hypertension, atrial fibrillation, obstructive sleep apnoea, and obesity. Tight-fitting swimsuits and excessive hydration before taking part in competitions should be avoided.</p>
<p>There have been interesting findings in studies investigating prophylactic sildenafil as a strategy to prevent IPO/SIPO through the drug’s activity lowering pressure in the pulmonary bed. However, it is important to note that sildenafil may be dangerous in divers. Phosphodiesterase-5 inhibitors have been found to potentially contribute to an increased risk of epileptic seizures attributable to the toxic effects of oxygen on the central nervous system<sup>(<a ref-type="bibr" href="#j_jou.2021.0041_ref_008">8</a>)</sup>.</p>
<p>In the competitor described in this case report, the diagnosis of IPO/SIPO was based on medical history and the results of additional examinations. Multi-stage diagnostic imaging also played a major role. A CT scan ruled out two serious cardiac conditions: pulmonary embolism and aortic dissection. At the same time, it confirmed parenchymal changes consistent with pulmonary oedema (previously visualised on chest X-ray).</p>
<p>A cardiac echo was performed to assess left ventricular morphology and function, and was normal. These findings, in combination with the patient’s previous medical history (no stenocardial complaints) and electrocardiographic results (no ischaemia), helped to exclude myocardial infarction with a high level of probability. Lung ultrasound, which revealed the presence of B-lines, was another modality to confirm parenchymal stasis, and was then used to monitor the patient’s condition.</p>
<p>Very interesting insights were gained from the echocardiographic assessment of right ventricular function. In the acute phase of the disease, there was moderate enlargement of the right ventricle. The right ventricular function parameters (TAPSE, FAC, longitudinal strain) were within the normal range for the population, though they were found to be significantly impaired in that particular patient. This was revealed in the patient’s reassessment performed after 30 days, which showed a change in the RVA/LVA ratio and a significant improvement in functional parameters.</p>
<p>The diagnostic imaging was complemented by an evaluation for ischemic heart disease performed by SPECT.</p>
</sec>
<sec id="j_jou.2021.0041_s_003" sec-type="conclusions">
<div>Conclusions</div>
<p>Immersion pulmonary oedema (IPO), also referred to as swimming-induced pulmonary oedema (SIPO) is a dangerous complication associated with the practice of certain sports, which occurs during swimming in cold water.</p>
<p>An important role in the diagnosis of IPO/SIPO is attributed to medical history-taking and combined diagnostic imaging In view of the growing interest in amateur swimming competitions (including triathlon) medical teams should be able to correctly identify IPO/SIPO in the competing athletes.</p>
</sec>
</div>

Immersion pulmonary oedema in a triathlete – a diagnostic challenge in sports cardiology

Journal of Ultrasonography

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Immersion pulmonary oedema, also referred to as swimming-induced pulmonary oedema, is a form of pulmonary oedema which usually occurs during swimming in cold...

Immersion pulmonary oedema in a triathlete – a diagnostic challenge in sports cardiology

Article Category: research-article

Publié en ligne: 09 sept. 2021

Pages: 252 - 257

Reçu: 04 mars 2021

Accepté: 31 mars 2021

DOI: https://doi.org/10.15557/jou.2021.0041

Mots clés
immersion pulmonary oedema, swimming-induced pulmonary oedema, triathlon, dyspnoea, sildenafil

© 2021 Polish Ultrasound Society. Published by Medical Communications Sp. z o.o.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Immersion pulmonary oedema in a triathlete – a diagnostic challenge in sports cardiology

Article Category: research-article

Publié en ligne: 09 sept. 2021

Pages: 252 - 257

Reçu: 04 mars 2021

Accepté: 31 mars 2021

DOI: https://doi.org/10.15557/jou.2021.0041

Mots clésimmersion pulmonary oedema, swimming-induced pulmonary oedema, triathlon, dyspnoea, sildenafil

© 2021 Polish Ultrasound Society. Published by Medical Communications Sp. z o.o.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
immersion pulmonary oedema, swimming-induced pulmonary oedema, triathlon, dyspnoea, sildenafil