<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and plays an important role in neuroplasticity, differentiation and survival of neurons, as well as their function. Neuroinflammation has been explored in the pathophysiology of many mental disorders, such as schizophrenia. Cytokines representing different types of immune responses have an impact on neurogenesis and BDNF expression. Cross-regulation of BDNF and cytokines is accomplished through several signalling pathways. Also, typical and atypical antipsychotic drugs variously modulate the expression of BDNF and serum levels of cytokines, which can possibly be used in evaluation of therapy effectiveness. Comorbidity of metabolic syndrome and atopic diseases has been considered in the context of BDNF and cytokines interplay in schizophrenia.</p></abstract>

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and plays an important role in neuroplasticity, differentiation and survival of neurons, as well as their function. Neuroinflammation has been explored in the pathophysiology of many mental disorders, such as schizophrenia. Cytokines representing different types of immune responses have an impact on neurogenesis and BDNF expression. Cross-regulation of BDNF and cytokines is accomplished through several signalling pathways. Also, typical and atypical antipsychotic drugs variously modulate the expression of BDNF and serum levels of cytokines, which can possibly be used in evaluation of therapy effectiveness. Comorbidity of metabolic syndrome and atopic diseases has been considered in the context of BDNF and cytokines interplay in schizophrenia.

Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia

Faculty of Medical Sciences, Department of Psychiatry

Faculty of Medical Sciences, Center for Molecular Medicine and Stem Cell Research

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia"}

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family and plays an important role in neuroplasticity, differentiation and survival of...

Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia

Article Category: Review Paper

Publié en ligne: 01 févr. 2020

Pages: 283 - 289

Reçu: 12 juin 2016

Accepté: 29 nov. 2016

DOI: https://doi.org/10.1515/sjecr-2017-0031

Mots clés
brain derived neurotrophic factor, cytokines, schizophrenia, metabolic syndrome, atopic diseases

© 2020 Slavica Minic Janicijevic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Interplay of Brain-Derived Neurotrophic Factor and Cytokines in Schizophrenia

Article Category: Review Paper

Publié en ligne: 01 févr. 2020

Pages: 283 - 289

Reçu: 12 juin 2016

Accepté: 29 nov. 2016

DOI: https://doi.org/10.1515/sjecr-2017-0031

Mots clésbrain derived neurotrophic factor, cytokines, schizophrenia, metabolic syndrome, atopic diseases

© 2020 Slavica Minic Janicijevic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
brain derived neurotrophic factor, cytokines, schizophrenia, metabolic syndrome, atopic diseases