<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In recent decades, steroid abuse has become very popular and widespread among professional and recreational athletes. The aim of this study was to examine the chronic effects of training combined with high doses of nandrolone decanoate on cardiac muscle tissue. The study included 32 Wistar albino rats divided into 4 groups: control (T-N-), steroid (T-N+), exercisetraining (T+N-) and exercise plus steroid (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 hour per day, 5 days per week. The N+ (nandrolone positive groups) received nandrolone decanoate (20 mg/kg) once per week, subcutaneously. After 4 weeks of training, the rats were sacrificed. Heart biopsy specimens were routinely fixed and embedded in paraffin. Fivemicrometre thick sections were stained with haematoxylin and eosin (H/E) and Masson-Trichrome dyes. Captured microscopic images were processed by special software for image analysis to quantify results. Our results showed that the combination of nandrolone and training causes left ventricular wall thickening of 30%. Average cardiac muscle cell longitudinal diameter was increased by 6% in the T-N+ group, by 16% in the T+N- group and by 25% in the T+N+ group. The cross sectional muscle cell area was increased in the T+N+ group by 33%. Heart collagen content was increased in the nandrolone group compared to the control group by 261%. Collagen content was decreased in the T+N+ group by 34%. High doses of AAS induced left ventricle hypertrophy and excessive heart collagen deposition. </p></abstract>

In recent decades, steroid abuse has become very popular and widespread among professional and recreational athletes. The aim of this study was to examine the chronic effects of training combined with high doses of nandrolone decanoate on cardiac muscle tissue. The study included 32 Wistar albino rats divided into 4 groups: control (T-N-), steroid (T-N+), exercisetraining (T+N-) and exercise plus steroid (T+N+) groups. The T+N- and T+N+ group swam for 4 weeks, 1 hour per day, 5 days per week. The N+ (nandrolone positive groups) received nandrolone decanoate (20 mg/kg) once per week, subcutaneously. After 4 weeks of training, the rats were sacrificed. Heart biopsy specimens were routinely fixed and embedded in paraffin. Fivemicrometre thick sections were stained with haematoxylin and eosin (H/E) and Masson-Trichrome dyes. Captured microscopic images were processed by special software for image analysis to quantify results. Our results showed that the combination of nandrolone and training causes left ventricular wall thickening of 30%. Average cardiac muscle cell longitudinal diameter was increased by 6% in the T-N+ group, by 16% in the T+N- group and by 25% in the T+N+ group. The cross sectional muscle cell area was increased in the T+N+ group by 33%. Heart collagen content was increased in the nandrolone group compared to the control group by 261%. Collagen content was decreased in the T+N+ group by 34%. High doses of AAS induced left ventricle hypertrophy and excessive heart collagen deposition.

The Effects of High Doses of Nandrolone Decanoate on Cardiac Muscle Tissue

Department of Physiology, Faculty of Medical Science, University of Kragujevac, Kragujevac,

Faculty of Medical Sciences Kragujevac, Department of Histology and Embryology Svetozara Markovica 69, 34000 Kragujevac,

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"The Effects of High Doses of Nandrolone Decanoate on Cardiac Muscle Tissue"}

In recent decades, steroid abuse has become very popular and widespread among professional and recreational athletes. The aim of this study was to examine the...

The Effects of High Doses of Nandrolone Decanoate on Cardiac Muscle Tissue

Publié en ligne: 13 déc. 2016

Pages: 303 - 308

Reçu: 19 févr. 2016

Accepté: 29 févr. 2016

DOI: https://doi.org/10.1515/sjecr-2016-0021

Mots clés
nandrolone decanoate, high doses, exercise, heart muscle

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The Effects of High Doses of Nandrolone Decanoate on Cardiac Muscle Tissue

Publié en ligne: 13 déc. 2016

Pages: 303 - 308

Reçu: 19 févr. 2016

Accepté: 29 févr. 2016

DOI: https://doi.org/10.1515/sjecr-2016-0021

Mots clésnandrolone decanoate, high doses, exercise, heart muscle

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
nandrolone decanoate, high doses, exercise, heart muscle