<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>. Studies often suggest hypoxemia is an important factor for sodium retention in chronic obstructive pulmonary disease (COPD), although hypercapnia is also associated with sodium retention in these patients. Hence, we have presented the major role of PaCO2 in edema due to COPD.<bold>Method</bold>. COPD patients who were hospitalized due to exacerbation were enrolled in the study and divided into two groups: with and without edema. Exclusion criteria included primary hepatic diseases, nephrotic syndrome and other renal diseases, left heart failure, or using drugs that would interfere with these organs or endocrine function. Data were coded and analyzed by SPSS software. Arterial blood gas variables including bicarbonate, pH, and PaO2, PaCO2 and O2 saturation, and FEV1, FVC, FEV1/FVC were measured and compared between the groups.<bold>Results</bold>. No significant difference was found between the averages of bicarbonate, pH, PaO2, O2 saturation, FEV1, FVC and FEV1/FVC in COPD in the two groups. PaCO2 levels were significantly higher in patients with edema, compared to those without edema (p = 0.05). A reverse and significant correlation between PaCo2 and FEV1 levels (p = 0.03) (r = −0.501) was observed in patients with edema.<bold>Conclusion</bold>. This study suggests that hypercapnia is a major factor in causing edema in COPD patients compared to hypoxemia.</abstract>

Introduction. Studies often suggest hypoxemia is an important factor for sodium retention in chronic obstructive pulmonary disease (COPD), although hypercapnia is also associated with sodium retention in these patients. Hence, we have presented the major role of PaCO2 in edema due to COPD.Method. COPD patients who were hospitalized due to exacerbation were enrolled in the study and divided into two groups: with and without edema. Exclusion criteria included primary hepatic diseases, nephrotic syndrome and other renal diseases, left heart failure, or using drugs that would interfere with these organs or endocrine function. Data were coded and analyzed by SPSS software. Arterial blood gas variables including bicarbonate, pH, and PaO2, PaCO2 and O2 saturation, and FEV1, FVC, FEV1/FVC were measured and compared between the groups.Results. No significant difference was found between the averages of bicarbonate, pH, PaO2, O2 saturation, FEV1, FVC and FEV1/FVC in COPD in the two groups. PaCO2 levels were significantly higher in patients with edema, compared to those without edema (p = 0.05). A reverse and significant correlation between PaCo2 and FEV1 levels (p = 0.03) (r = −0.501) was observed in patients with edema.Conclusion. This study suggests that hypercapnia is a major factor in causing edema in COPD patients compared to hypoxemia.

The Effect of Arterial PaCO2 in COPD Exacerbations with and without Peripheral Edema

Lung Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Research Center for Patient Safety & Health Quality, Mashhad University of Medical Sciences, Mashhad, Iran

Preventive Cardiovascular Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of Arterial PaCO in COPD Exacerbations with and without Peripheral Edema

Introduction. Studies often suggest hypoxemia is an important factor for sodium retention in chronic obstructive pulmonary disease (COPD), although hypercapnia...

The Effect of Arterial PaCO₂ in COPD Exacerbations with and without Peripheral Edema

Publié en ligne: 10 déc. 2015

Pages: 343 - 347

Reçu: 30 juin 2014

DOI: https://doi.org/10.1515/rjim-2015-0044

Mots clés
Arterial, PaCO, Edema, Chronic obstructive pulmonary disease

© 2015 Fariba Rezaeetalab et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of Arterial PaCO2 in COPD Exacerbations with and without Peripheral Edema

Publié en ligne: 10 déc. 2015

Pages: 343 - 347

Reçu: 30 juin 2014

DOI: https://doi.org/10.1515/rjim-2015-0044

Mots clésArterial, PaCO, Edema, Chronic obstructive pulmonary disease

© 2015 Fariba Rezaeetalab et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Effect of Arterial PaCO₂ in COPD Exacerbations with and without Peripheral Edema

Mots clés
Arterial, PaCO, Edema, Chronic obstructive pulmonary disease