Efficacy of long-term low-dose sulodexide in diabetic and non-diabetic nephropathies

1. MASOLA V, ZAZA G, GAMBARO G. Sulodexide and glycosaminoglycans in the progression of renal disease. Nephrol Dial Transplant 2014; 29: i74-i79.10.1093/ndt/gft38924493873Search in Google Scholar

2. LAUVER DA, LUCCHESI BR. Sulodexide: a renewed interest in this glycosaminoglycan. Cardiovascular Drug Reviews 2006; 24(3-4): 214-226.10.1111/j.1527-3466.2006.00214.x17214598Search in Google Scholar

3. LAUVER DA, LUCCHESI BR. Sulodexide: A renewed interest in this glycosaminoglycan. Cardiovascular Drug Reviews 2006; 24(3–4): 214–226. 210.1111/j.1527-3466.2006.00214.xSearch in Google Scholar

4. MANELLO F, MEDDA V, LIGI D, RAFFETTO JD. Glycosaminoglycan sulodexide inhibition of MMP-9 gelatinase secretion and activity: possible pharmacological role against collagen degradation in vascular chronic diseases. Curr Vasc Pharm 2013; 11: 354-365.10.2174/157016111131103001022724470Search in Google Scholar

5. BROEKHUIZEN LN, LEMKES BA, MOOIJ HL et al. Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus. Diabetologia 2010; 53: 2646–2655.10.1007/s00125-010-1910-x297492020865240Search in Google Scholar

6. KRISTOVA V, LISKOVA S, SOTNIKOVA R et al. Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats. Physiol Res 2008; 57: 491–494.10.33549/physiolres.93150618597586Search in Google Scholar

7. COFFEY AK, KARNOVSKY MJ. Heparin inhibits mesangial cell proliferation in habu-venom-induced glomerular injury. Am J Pathol 1985; 120: 248–255.Search in Google Scholar

8. LEWIS EJ, XU X. Abnormal glomerular permeability characteristics in diabetic nephropathy: implications for the therapeutic use of low-molecular weight heparin. Diabetes Care 2008; 31(Suppl 2): S202–S207.10.2337/dc08-s25118227486Search in Google Scholar

9. CEOL M, GAMBARO G, SAUER U et al. Glycosaminoglycan therapy prevents TGF-beta1 overexpression and pathologic changes in renal tissue of long term diabetic rats. J Am Soc Nephrol 2000; 11: 2324–2336.10.1681/ASN.V1112232411095655Search in Google Scholar

10. MASOLA V, ONISTO M, ZAZA G, LUPO A, GAMBARO G. A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition. J Translational Medicine 2012; 10: 213.10.1186/1479-5876-10-213356225723095131Search in Google Scholar

11. GADDI A, CICERO AFG, GAMBARO G. Nephroprotective action of glycosaminoglycans: why the pharmacological properties of Sulodexide might be reconsidered. Int J Nephrol Renovasc Dis 2010; 3: 99-105.Search in Google Scholar

12. SOLINI A, CARRARO A, BARZON I et al. Therapy with glycosaminoglycans lowers albumin excretion rate in non-insulin dependent diabetic patients with microalbuminuria. Diab Nutr Metab 1994; 7: 304–307.Search in Google Scholar

13. GAMBARO G, KINALSKA I, OKSA A, et al. Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric Type 1 and Type 2 diabetic patients: The Di.N.A.S. randomized trial. J Am Soc Nephrol 2002; 13: 1615–1625.10.1097/01.ASN.0000014254.87188.E5Search in Google Scholar

14. BLOUZA S, DAKHLI S, ABID H et al. Efficacy of low-dose oral sulodexide in the management of diabetic nephropathy. J Nephrol 2010; 23: 415–424.Search in Google Scholar

15. ROZITA M, MD SHAHRIR MS, LOO CY et al. Glycosaminoglycans (sulodexide) for resistant heavy proteinuria of chronic glomerulonephritides. Nephrology 2008; 13(Suppl 1): A13.Search in Google Scholar

16. BANG K, CHIN HJ, CHAE DW et al. Anti-proteinuric effect of sulodexide in Immunoglobulin A Nephropathy. Yonsei Med J 2011; 52: 588–594.10.3349/ymj.2011.52.4.588310445521623600Search in Google Scholar

17. PALATINI P. Glomerular hyperfiltration: a marker of early renal damage in pre-diabetes and pre-hypertension. Nephrol Dial Transplant 2012; 27: 1708-1714.10.1093/ndt/gfs03722431709Search in Google Scholar

18. CHRISTIANSEN REF, TENSTAD O, LEH S, IVERSEN BM. Glomerular charge selectivity is impaired in hypertensive nephropathy. Nephrol Dial Transplant, 2004; 19: 1083-1091.10.1093/ndt/gfh10114993487Search in Google Scholar

19. HEERSPINK HL, GREENE T, LEWIS JB, et al. Collaborative Study Group. Effects of Sulodexide in patients with type 2 diabetes and persistent albuminuria. Nephrol Dial Transplant 2008; 23(6):1946–1954.10.1093/ndt/gfm89318089623Search in Google Scholar

20. LI P, MA LL, XIE RJ, et al. Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure. Acta Pharmacologica Sinica 2012; 33: 644–651.10.1038/aps.2012.2401034922555371Search in Google Scholar