Accès libre

Dynamic susceptibility contrast enhanced (DSC) MRI perfusion and plasma cytokine levels in patients after tonic-clonic seizures

Tatjana Filipovic
Tatjana Filipovic
, 
Katarina Surlan Popovic
Katarina Surlan Popovic
, 
Alojz Ihan
Alojz Ihan
 et 
David Bozidar Vodusek
David Bozidar Vodusek
   | 14 août 2017
Radiology and Oncology's Cover Image
À propos de cet article
Article précédent
Article suivant
Citez
Article Category: Research Article
Publié en ligne: 14 août 2017
Pages: 277 - 285
Reçu: 17 avr. 2017
Accepté: 14 juin 2017
DOI: https://doi.org/10.1515/raon-2017-0031
© 2017 Tatjana Filipovic, Katarina Surlan Popovic, Alojz Ihan, David Bozidar Vodusek
This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

increased blood flow (arrow) in the region of the left medial cerebral artery; signal changes adjacent to left frontal bone (asterix) are the artefact (patient 15)
increased blood flow (arrow) in the region of the left medial cerebral artery; signal changes adjacent to left frontal bone (asterix) are the artefact (patient 15)

Median concentrations of cytokines (pg/ml) and hs CRP(mg/l) in three subgroups of patients (see text for details)

IL-4 IL-6 IL-10 IL-12 TNF-α IFN-γ IL-1Ra hsCRP
Normoperfusion 0,6 4,3 11 60,1 7,3 15,1 677 0,9
Hyperperfusion 0,3

Statistically significant difference (p < 0. 05)

 1,5 63,7 44,5 9,7

Statistically significant difference (p < 0. 05)

 14 407

Statistically significant difference (p < 0. 05)

 1.3
Control hyperperfusion

Due to a small number of patients (2) the significance was not tested. H kateri tabeli spada ta podnapis. Nisem opazil superskripta 1. Statistična pojasnila k tabelam označujete z zvezdico in bi tudi to opombo.

 0,5 6,0 5,1 110,4 10,6 27,7 868 1,6

Basic and control concentrations of cytokines (pg/ml) in patients with hyperperfusion after index seizure(s)

Patient IL-4 IL-6 IL-10 IL-12 TNF-α IFN-γ IL-1Ra hsCRP
2 (1st) 0,08 <2 116 54,5 8,19 13,08 352 1,5
(control) 0,3 <2 134 99,6 8,97 9,23 822 1,7
3 (1st) / / / / / / / /
(control) 1,77 <2 12,6 127 11,5 108 1479 0,9
7

Patient demonstrated hyperperfusion also on control MRI after three months.

 (1st) 0,41 2,47 10,02 24,8 11,7 44,56 676 1,9
(control) 0,35 <2 29,8 41,8 12,1 31 361 1,8
15

Patient demonstrated hyperperfusion also on control MRI after three months.

 (1st) 0,61 9,49 0,22 196 9,57 10,81 1060 1,4
(control) 0,00 <2 0,58 150 14,1 14,7 593 0,7
25 (1st) 0,38 <2 11,51 34,6 11,1 14,97 462 1,1
(control) 1,01 <2 12,0 42,5 20,2 16,2 660 1,4

Blood cytokine concentration after index seizure(s)

N M Me SD Ref. No (%) above/below reference
IL-4(pg/ml) 29

patient 3 is not included

 0.9 0.6 1.3 ≤ 1 7(24)
IL-6 (pg/ml) 29

patient 3 is not included

 5.7 3.7 5.1 ≤ 3.9 15(52)
IL-10 (pg/ml) 29

patient 3 is not included

 42.8 11.4 10.2 ≤ 10.9 16(55)
IL-12 (pg/ml) 29

patient 3 is not included

 66 58.5 40.3 ≤ 204 29(100)
TNFα (pg/ml) 29

patient 3 is not included

 8.5 7.6 4 4.7-12.4 1(3)
IFN-γ (pg/ml) 29

patient 3 is not included

 27.5 15 54.4 ≤ 1.2 7(24)
IL-1Ra (pg/ml) 29

patient 3 is not included

 1302.7 676 1797 168-744 14(48)
Hs CRP (mg/l) 29

patient 3 is not included

 2.9 1.1 4,5 < 3 29(100)

MRI perfusion parameters after index seizures (grey matter)

N M Me SD
N BF 25 101,7 93 40,8
N BV 25 8 7 3,9
N MTT 25 6,9 6,9 2,9
N TTP 25 13,9 13,8 2,3
P BF 5 265,85

statistically significant difference (p < 0,001)

 234 56,3
P   BV 5 25,5

statistically significant difference (p < 0,001)

 27,6 4,7
P   MTT 5 5,7 5 1,2
P   TTP 5 14,5 13,5 4,5

Demographical and clinical data

Sex age, Smoking status Illness Duration (yr) syndrome EEG FREQUENCY N-INDEX AED TYPE /NHS3 Structural MRI Follow up
1 F 65 / 7 PFS G V 4 LAM, LEV 2(5/10) Leucopathy 0
2 F 38 5 7 PFS G R 1 LEV* 2(2/10) N 0
3 M 26 / 3 / N R 1 LEV* 2(2/12) N 0
4 F 65 / / / G 1st 1 / 1(11) N 0
5 F 23 / 15 FS F(RF) V 1 TPM,LAM,DPH 2(2/12) Resection RF >100
6 M 35 / 20 FS F(RF) R 1 LAM 2(2/10) N 0
7 M 42 / 1 Fs F(RT) 1st 1 LEV* 1(18) N 5
8 F 20 10 7 IGE G O 1 VA 2(2/13) N 0
9 F 24 / 1 / N 2nd 1 / 1(12) N 0
10 M 21 20 6 PFS N 0 1 LEV* 1(13) N 0
11 M 29 / 12 IGE G O 1 VA 2(2/14) N 0
12 M 46 / / FS F(LT) 1st 1 LEV*PREG** 1(13) EncephalomalacyLT 0
13 F 57 / / / F(RF) 1st 1 /
14 M 27 / 7 FS F(LT) R 1 LEV* 1(18) N 6
15 F 54 / 8 PFS N O 1 LEV 1(11) N 0
16 M 44 10 5 FS F(LF) O 3 LAM 1(12) N 0
17 F 45 / 20 PFS N R 1 LAM 1(15) N 0
18 M 30 10 12 FS F(RF) O 1 LAM 1(18) Gliosis RF 5
19 M 63 / 4 FS F(RT) O 5 LEV 2(2/18) MTS R 12
20 M4 0 / 20 FS F(RT) O 1 CBZ 2(2/15) N 12
21 M 41 / 20 FS F(LT) V 5 CBZ,VA 1(10) N 50
22 M 23 / 8 IGE G V 3 LAM 1(18) N 47
23 F 29 / 11 FS F(RT) V 2 TPM,LAM 1(20) Cortical. DysplasiaRT 5
24 M 27 / 12 IGE G O 7 VA* 1(9) N 2
25 M 21 10 6 IGE G O 6 VA 2(2/8) N 0
26 F 50 20 34 FS F(LT) R 1 / 1(8) Aneurysm L MCA 0
27 F 43 / 25 PFS N V 3 LAM 1(11) Gliosis RF 0
28 M 50 / 40 IGE G V 1 LAM,LEV 1(19) Cerebellaratrophy 18
29 M 39 / 32 / G R 1 / 1(8) N 0
30 M 19 10 5 / G R 1 CBZ* 1(9) N 0

EEG and syndrome

EEG and syndrome N (%)
Frequency R 8 (27)
O 11(37)
V 6(20)
Syndrome PFS 6(20)
FS 12(40)
IGE 6(20)
undetermined 6(20)
EEG Normal 4(13)
Focal 12(40)
Generalized 5(17)
IGE 6(20)
undetermined 3(10)
Focus
RT 4(33)
LT 5(41)
RF 2(16)
LF 1(8)

Correlation between cytokine concentrations and number of index seizures

Cytokine concentration Pearson’s coefficient of correlation ρ
IL-4 (pg/ml) 0,07
IL-6 (pg/ml) 0,23
IL-10 (pg/ml) -0,37

weak correlation;

IL-12 (pg/ml) 0,24
TNFα (pg/ml) -0,41

moderate correlation

IFN-ϒ (pg/ml) -0,39

weak correlation;

IL-1Ra (pg/ml) -0,22
hsCRP -0,16
eISSN:
1581-3207
Langue:
Anglais
Périodicité:
4 fois par an
Sujets de la revue:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology
RSS Feed de la revue