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The ratio of weight loss to planning target volume significantly impacts setup errors in nasopharyngeal cancer patients undergoing helical tomotherapy with daily megavoltage computed tomography

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Setup error of the medial-lateral (ML) direction at each treatment fraction.
Setup error of the medial-lateral (ML) direction at each treatment fraction.

Setup error of the superior-inferior (SI) direction at each treatment fraction.
Setup error of the superior-inferior (SI) direction at each treatment fraction.

Setup error of the anterior-posterior (AP) direction at each treatment fraction.
Setup error of the anterior-posterior (AP) direction at each treatment fraction.

Linear regression graph of anterior-posterior (AP) setup error and weight loss normalized by planning target volume (PTV) (R2 = 0.059, p < 0.001).
Linear regression graph of anterior-posterior (AP) setup error and weight loss normalized by planning target volume (PTV) (R2 = 0.059, p < 0.001).

Setup errors by the specified threshold

ML error (%)SI error (%)AP error (%)
< 1.0 mm3549 (49.1)2471 (34.2)525 (7.3)
1.0~1.9 mm2315 (32.0)2076 (28.7)939 (13.0)
2.0~2.9 mm925 (12.8)1390 (19.2)1492 (20.6)
3.0~3.9 mm314 (4.3)729 (10.1)1800 (24.9)
4.0~4.9 mm85 (1.2)330 (4.6)1310 (18.1)
≥ 5.0 mm45 (0.6)237 (3.3)1167 (16.1)

Patient characteristics (n = 217)

VariableNumber (%)
Age
Median46
Range17–76
Sex
Male160(73.7)
Female57(26.3)
T stage
197(44.7)
232(14.7)
350(23.0)
438(17.5)
N stage
051(23.5)
167(30.9)
267(30.9)
3a18(8.3)
3b15(6.9)
AJCC stage
I29(13.4)
II47(21.7)
III76(35.0)
IVA32(14.7)
IVB33(15.2)
Chemotherapy
No27(12.4)
Yes190(87.6)
Fraction
33 (2.12 Gy/fraction)182(83.9)
35 (2 Gy/fraction)35(16.1)

Setup error by clinical factors

ML errorSI errorAP error
Overall1.2 ± 0.61.8 ± 0.83.4 ± 1.4
T stage
1,2 (n = 129)1.2 ± 0.61.8 ± 0.93.3 ± 1.5
3,4 (n = 88)1.1 ± 0.51.7 ± 0.83.5 ± 1.3
p value0.2410.8140.414
N stage
0, 1 (n = 117)1.1 ± 0.61.7 ± 0.83.4 ± 1.3
2, 3a, 3b (n = 100)1.2 ± 0.61.9 ± 0.93.4 ± 1.5
p value0.1330.2390.890
BMI
< 25 (n = 138)1.2 ± 0.61.7 ± 0.83.2 ± 1.3
≥ 25 (n = 79)1.2 ± 0.51.9 ± 0.93.6 ± 1.5
p value0.8450.1770.053
PTV
< 850 cc (n = 113)1.2 ± 0.71.9 ± 0.93.6 ± 1.5
≥ 850 cc (n = 104)1.2 ± 0.51.6 ± 0.73.2 ± 1.3
p value0.2920.0210.03
Weight loss
≤ 5% (n = 84)1.1 ± 0.41.6 ± 0.72.9 ± 1.1
> 5% (n = 133)1.2 ± 0.61.9 ± 0.93.6 ± 1.5
p value0.2790.010<0.001
eISSN:
1581-3207
Langue:
Anglais
Périodicité:
4 fois par an
Sujets de la revue:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology