Single nucleotide polymorphisms in genes MACC1, RAD18, MMP7 and SDF-1a as prognostic factors in resectable colorectal cancer
Catégorie d'article: Research Articles
Publié en ligne: 08 sept. 2016
Pages: 151 - 159
Reçu: 05 févr. 2016
Accepté: 27 mai 2016
DOI: https://doi.org/10.1515/raon-2016-0043
Mots clés
© 2017 Matej Horvat, Uros Potocnik, Katja Repnik, Rajko Kavalar, Vesna Zadnik, Stojan Potrc, Borut Stabuc
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background
Colorectal cancer (CRC) represents one of the most common malignancies worldwide. Research has indicated that functional gene changes such as single nucleotide polymorphism (SNP) influence carcinogenesis and metastasis and might have an influence on disease relapse. The aim of our study was to evaluate the role of SNPs in selected genes as prognostic markers in resectable CRC.
Patients and methods
In total, 163 consecutive patients treated surgically for CRC of stages I, II and III at the University Medical Centre in Maribor in 2007 and 2008 were investigated. DNA was isolated from formalin-fixed paraffin-embedded CRC tissue from the Department of Pathology and SNPs in genes
Results
We found worse disease-free survival (DFS) for patients with TT genotype of SNP rs1990172 in gene
Conclusions
Our results indicate the role of SNPs as prognostic factors in resectable CRC.